{"id":"https://openalex.org/W2167936920","doi":"https://doi.org/10.1093/bioinformatics/btn379","title":"ExactFDR: exact computation of false discovery rate estimate in case-control association studies","display_name":"ExactFDR: exact computation of false discovery rate estimate in case-control association studies","publication_year":2008,"publication_date":"2008-07-28","ids":{"openalex":"https://openalex.org/W2167936920","doi":"https://doi.org/10.1093/bioinformatics/btn379","mag":"2167936920","pmid":"https://pubmed.ncbi.nlm.nih.gov/18662924"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn379","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn379","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2407/49051871/bioinformatics_24_20_2407.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2407/49051871/bioinformatics_24_20_2407.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057755023","display_name":"J\u00e9r\u00f4me Wojcik","orcid":"https://orcid.org/0000-0003-3250-2884"},"institutions":[{"id":"https://openalex.org/I4210113211","display_name":"Merck Serono (Switzerland)","ror":"https://ror.org/01vp49361","country_code":"CH","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210113211"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"J\u00e9r\u00f4me Wojcik","raw_affiliation_strings":["Department of Bioinformatics, Merck Serono Geneva Research Center, 1202 Geneva, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Merck Serono Geneva Research Center, 1202 Geneva, Switzerland","institution_ids":["https://openalex.org/I4210113211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029625313","display_name":"Karl Forner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113211","display_name":"Merck Serono (Switzerland)","ror":"https://ror.org/01vp49361","country_code":"CH","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210113211"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Karl Forner","raw_affiliation_strings":["Department of Bioinformatics, Merck Serono Geneva Research Center, 1202 Geneva, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Merck Serono Geneva Research Center, 1202 Geneva, Switzerland","institution_ids":["https://openalex.org/I4210113211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057755023"],"corresponding_institution_ids":["https://openalex.org/I4210113211"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.1862,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63860253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"24","issue":"20","first_page":"2407","last_page":"2408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.8425874710083008},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.7180959582328796},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.6848894357681274},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.6734570264816284},{"id":"https://openalex.org/keywords/false-positives-and-false-negatives","display_name":"False positives and false negatives","score":0.6646548509597778},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.6469957828521729},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.56972736120224},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.523481011390686},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5114830732345581},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.4526599645614624},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3638305068016052},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3474441468715668},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3463372588157654},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23674258589744568},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09789493680000305}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.8425874710083008},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.7180959582328796},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.6848894357681274},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.6734570264816284},{"id":"https://openalex.org/C112789634","wikidata":"https://www.wikidata.org/wiki/Q18207010","display_name":"False positives and false negatives","level":3,"score":0.6646548509597778},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.6469957828521729},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.56972736120224},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.523481011390686},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5114830732345581},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4526599645614624},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3638305068016052},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3474441468715668},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3463372588157654},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23674258589744568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09789493680000305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn379","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn379","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2407/49051871/bioinformatics_24_20_2407.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18662924","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18662924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:zenodo.org:100693","is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/100693","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn379","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn379","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2407/49051871/bioinformatics_24_20_2407.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167936920.pdf","grobid_xml":"https://content.openalex.org/works/W2167936920.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W1964895626","https://openalex.org/W2047129206","https://openalex.org/W2078825048","https://openalex.org/W2110065044","https://openalex.org/W2113381189","https://openalex.org/W2169294950"],"related_works":["https://openalex.org/W2020413892","https://openalex.org/W1991225657","https://openalex.org/W2903672469","https://openalex.org/W4388328864","https://openalex.org/W2093463665","https://openalex.org/W2102122784","https://openalex.org/W2079592427","https://openalex.org/W2317297514","https://openalex.org/W256699647","https://openalex.org/W1825621501"],"abstract_inverted_index":{"Genome-wide":[0],"association":[1,35,121],"studies":[2],"require":[3],"accurate":[4,93],"and":[5,43,56,92,108,113],"fast":[6],"statistical":[7],"methods":[8],"to":[9,41],"identify":[10],"relevant":[11],"signals":[12],"from":[13],"the":[14,47,50,59,69,73,77,80,97,117],"background":[15],"noise":[16],"generated":[17],"by":[18,67,76],"a":[19,90,103],"huge":[20],"number":[21],"of":[22,34,58,72,79,96,99,106,119],"simultaneously":[23],"tested":[24],"hypotheses.":[25],"It":[26,88],"is":[27,109],"now":[28],"commonly":[29],"accepted":[30],"that":[31],"exact":[32,86],"computations":[33],"probability":[36],"value":[37],"(P-value)":[38],"are":[39],"preferred":[40],"chi(2)":[42],"permutation-based":[44,60,70],"approximations.":[45],"Following":[46],"same":[48],"principle,":[49],"ExactFDR":[51],"software":[52],"package":[53],"improves":[54],"speed":[55],"accuracy":[57],"false":[61,100],"discovery":[62],"rate":[63],"(FDR)":[64],"estimation":[65,71],"method":[66],"replacing":[68],"null":[74],"distribution":[75],"generalization":[78],"algorithm":[81],"used":[82],"for":[83,116],"computing":[84],"individual":[85],"P-values.":[87],"provides":[89],"quick":[91],"non-conservative":[94],"estimator":[95],"proportion":[98],"positives":[101],"in":[102],"given":[104],"selection":[105],"markers,":[107],"therefore":[110],"an":[111],"efficient":[112],"pragmatic":[114],"tool":[115],"analysis":[118],"genome-wide":[120],"studies.":[122]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}