{"id":"https://openalex.org/W2117066633","doi":"https://doi.org/10.1093/bioinformatics/btn256","title":"Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells","display_name":"Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells","publication_year":2008,"publication_date":"2008-06-06","ids":{"openalex":"https://openalex.org/W2117066633","doi":"https://doi.org/10.1093/bioinformatics/btn256","mag":"2117066633","pmid":"https://pubmed.ncbi.nlm.nih.gov/18540022"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn256","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn256","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/16/1745/49050823/bioinformatics_24_16_1745.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/16/1745/49050823/bioinformatics_24_16_1745.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100457571","display_name":"Meng Li","orcid":"https://orcid.org/0000-0003-3553-0813"},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Meng Li","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062432580","display_name":"Hyun-il Henry Paik","orcid":null},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Hyun-il Henry Paik","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112036995","display_name":"Curt Balch","orcid":null},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Curt Balch","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059225337","display_name":"Yoo-Sung Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Yoosung Kim","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383612","display_name":"Lang Li","orcid":"https://orcid.org/0000-0002-0746-1809"},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Lang Li","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110259719","display_name":"Tim H-M. Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Tim H-M. Huang","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061888144","display_name":"Kenneth P. Nephew","orcid":"https://orcid.org/0000-0003-2192-1346"},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Kenneth P. Nephew","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100460452","display_name":"Sun Kim","orcid":"https://orcid.org/0000-0003-3072-6649"},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"funder","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Sun Kim","raw_affiliation_strings":["1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA"],"affiliations":[{"raw_affiliation_string":"1 Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, 2Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47405, 3School of Informatics, Indiana University, Bloomington, IN 47408, 4IU Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA, 5School of Information and Communication Engineering, Inha University, Incheon 402-751, Korea, 6Department of Biostatistics, Indiana University, Indianapolis, IN 46202, 7Human Cancer Genetics, The Ohio State University, Columbus, OH 43210, 8Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, IN 46202 and 9Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47404, USA","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I1283055418","https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100457571"],"corresponding_institution_ids":["https://openalex.org/I1283055418","https://openalex.org/I191879574","https://openalex.org/I4210119109","https://openalex.org/I52357470","https://openalex.org/I55769427"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.9682,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75076423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"16","first_page":"1745","last_page":"1748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.7850594520568848},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.7489902377128601},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.731629490852356},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6825296878814697},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.6734192967414856},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5260648131370544},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5136818289756775},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.513498842716217},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5049386620521545},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.48586505651474},{"id":"https://openalex.org/keywords/epigenetics-of-physical-exercise","display_name":"Epigenetics of physical exercise","score":0.4626202881336212},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3634756803512573},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3456287980079651}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.7850594520568848},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7489902377128601},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.731629490852356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6825296878814697},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.6734192967414856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5260648131370544},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5136818289756775},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.513498842716217},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5049386620521545},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.48586505651474},{"id":"https://openalex.org/C37080517","wikidata":"https://www.wikidata.org/wiki/Q18353747","display_name":"Epigenetics of physical exercise","level":5,"score":0.4626202881336212},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3634756803512573},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3456287980079651}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn256","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn256","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/16/1745/49050823/bioinformatics_24_16_1745.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18540022","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18540022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2732208","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2732208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn256","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn256","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/16/1745/49050823/bioinformatics_24_16_1745.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117066633.pdf","grobid_xml":"https://content.openalex.org/works/W2117066633.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1501700213","https://openalex.org/W1504303645","https://openalex.org/W1965722916","https://openalex.org/W1966354133","https://openalex.org/W1969373767","https://openalex.org/W2014199504","https://openalex.org/W2056473117","https://openalex.org/W2058549086","https://openalex.org/W2075896055","https://openalex.org/W2075922733","https://openalex.org/W2080973982","https://openalex.org/W2094036688","https://openalex.org/W2098582295","https://openalex.org/W2100097357","https://openalex.org/W2102179098","https://openalex.org/W2106605842","https://openalex.org/W2110065044","https://openalex.org/W2115954319","https://openalex.org/W2119615097","https://openalex.org/W2129571249","https://openalex.org/W2134877714","https://openalex.org/W2136707328","https://openalex.org/W2147658756","https://openalex.org/W2159072674","https://openalex.org/W2164277862","https://openalex.org/W4237247596","https://openalex.org/W6683549270"],"related_works":["https://openalex.org/W2169344098","https://openalex.org/W2033655940","https://openalex.org/W2078757082","https://openalex.org/W2944524138","https://openalex.org/W2364944693","https://openalex.org/W2582088144","https://openalex.org/W2006528877","https://openalex.org/W4200236841","https://openalex.org/W2123238153","https://openalex.org/W2362561464"],"abstract_inverted_index":{"In":[0,61],"this":[1],"study,":[2],"we":[3,63],"utilized":[4],"bioinformatics":[5],"tools":[6],"and":[7,78,84],"TF":[8],"binding":[9],"site(TFBs)":[10],"databases":[11],"to":[12,70],"globally":[13],"analyze":[14],"sequences":[15,48],"methylated":[16],"in":[17,35,46,52,57,81],"a":[18,68],"laboratory":[19],"model":[20],"for":[21],"the":[22,73],"development":[23],"of":[24,41],"drug-resistant":[25,58],"cancer.":[26],"Our":[27],"results":[28],"demonstrated":[29],"that":[30,65],"four":[31],"TFBS":[32,43],"were":[33,55],"enriched":[34],"hypermethylated":[36],"sequences.":[37],"More":[38],"interestingly,":[39],"overrepresentation":[40],"these":[42],"was":[44],"observed":[45,56],"hyper-/hypo-methylated":[47],"where":[49],"signi.cant":[50],"changes":[51],"methylation":[53,77],"levels":[54],"cancer":[59],"cells.":[60],"summary,":[62],"believe":[64],"these.ndings":[66],"offer":[67],"means":[69],"further":[71],"explore":[72],"relationship":[74],"between":[75],"DNA":[76],"gene":[79],"expression":[80],"drug":[82],"resistance":[83],"tumorigenesis.":[85]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-17T18:11:37.981687","created_date":"2025-10-10T00:00:00"}