{"id":"https://openalex.org/W2115005037","doi":"https://doi.org/10.1093/bioinformatics/btm366","title":"Quality estimation of multiple sequence alignments by Bayesian hypothesis testing","display_name":"Quality estimation of multiple sequence alignments by Bayesian hypothesis testing","publication_year":2007,"publication_date":"2007-07-27","ids":{"openalex":"https://openalex.org/W2115005037","doi":"https://doi.org/10.1093/bioinformatics/btm366","mag":"2115005037"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm366","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm366","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/bioinformatics/btm366","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110412581","display_name":"Andrija Tomovi\u0107","orcid":null},"institutions":[{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]},{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4210161228","display_name":"CH Foundation","ror":"https://ror.org/05nnhd665","country_code":"US","type":"other","lineage":["https://openalex.org/I4210161228"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Andrija Tomovic","raw_affiliation_strings":["Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerestrasse 66, CH-4056 Basel"],"affiliations":[{"raw_affiliation_string":"Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerestrasse 66, CH-4056 Basel","institution_ids":["https://openalex.org/I860889466","https://openalex.org/I1283582996","https://openalex.org/I4210161228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022644248","display_name":"Edward J. Oakeley","orcid":"https://orcid.org/0000-0001-6226-7470"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]},{"id":"https://openalex.org/I4210161228","display_name":"CH Foundation","ror":"https://ror.org/05nnhd665","country_code":"US","type":"other","lineage":["https://openalex.org/I4210161228"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Edward J. Oakeley","raw_affiliation_strings":["Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerestrasse 66, CH-4056 Basel"],"affiliations":[{"raw_affiliation_string":"Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerestrasse 66, CH-4056 Basel","institution_ids":["https://openalex.org/I860889466","https://openalex.org/I1283582996","https://openalex.org/I4210161228"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110412581"],"corresponding_institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4210161228","https://openalex.org/I860889466"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.5378,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66394094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"23","issue":"18","first_page":"2488","last_page":"2490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.6709896326065063},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6047265529632568},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.5405001640319824},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5156680345535278},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5016574859619141},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4575374126434326},{"id":"https://openalex.org/keywords/quality","display_name":"Quality (philosophy)","score":0.42349645495414734},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3846229612827301},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3070996403694153},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.306379109621048},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28171372413635254},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11386236548423767}],"concepts":[{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.6709896326065063},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6047265529632568},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.5405001640319824},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5156680345535278},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5016574859619141},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4575374126434326},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.42349645495414734},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3846229612827301},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3070996403694153},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.306379109621048},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28171372413635254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11386236548423767},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm366","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm366","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:doc.rero.ch:296513","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm366","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm366","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310389","display_name":"Novartis Foundation","ror":"https://ror.org/02f9zrr09"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1592870802","https://openalex.org/W1963866954","https://openalex.org/W1966833356","https://openalex.org/W2003967338","https://openalex.org/W2019841176","https://openalex.org/W2043463019","https://openalex.org/W2061029680","https://openalex.org/W2076540369","https://openalex.org/W2077013196","https://openalex.org/W2084620487","https://openalex.org/W2094519647","https://openalex.org/W2097396311","https://openalex.org/W2103630240","https://openalex.org/W2107511706","https://openalex.org/W2109745159","https://openalex.org/W2110455321","https://openalex.org/W2126163471","https://openalex.org/W2141408320","https://openalex.org/W2147258750","https://openalex.org/W2148450265","https://openalex.org/W2160446587","https://openalex.org/W6635200387","https://openalex.org/W6676479977","https://openalex.org/W6681451191"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4224009465","https://openalex.org/W2112284452","https://openalex.org/W4306674287","https://openalex.org/W4286629047","https://openalex.org/W4205958290","https://openalex.org/W4384212932","https://openalex.org/W3085798047","https://openalex.org/W4390590544","https://openalex.org/W2374269412"],"abstract_inverted_index":{"Abstract":[0],"Summary:":[1],"In":[2],"this":[3],"work":[4],"we":[5,79,93],"present":[6],"a":[7,32,39,103],"web-based":[8],"tool":[9,107],"for":[10],"estimating":[11],"multiple":[12],"alignment":[13,119],"quality":[14],"using":[15],"Bayesian":[16,82],"hypothesis":[17,83],"testing.":[18],"The":[19],"proposed":[20],"method":[21,37],"is":[22,112],"very":[23],"simple,":[24],"easily":[25],"implemented":[26],"and":[27,48,52,66],"not":[28],"time":[29],"consuming":[30],"with":[31,56],"linear":[33],"complexity.":[34],"We":[35],"evaluated":[36],"against":[38],"series":[40],"of":[41,46,75,105,118],"different":[42],"alignments":[43],"(a":[44],"set":[45],"random":[47],"biologically":[49],"derived":[50],"alignments)":[51],"compared":[53],"the":[54,76,90,115],"results":[55],"tools":[57],"based":[58,113],"on":[59,87,114],"classical":[60,91],"statistical":[61,116],"methods":[62,92],"(such":[63],"as":[64,71,102],"sFFT":[65],"csFFT).":[67],"Taking":[68],"correlation":[69],"coefficient":[70],"an":[72],"objective":[73],"criterion":[74],"true":[77],"quality,":[78],"found":[80],"that":[81],"testing":[84],"performed":[85],"better":[86],"average":[88],"than":[89],"tested.":[94],"This":[95],"approach":[96],"may":[97],"be":[98],"used":[99],"independently":[100],"or":[101],"component":[104],"any":[106],"in":[108],"computational":[109],"biology":[110],"which":[111],"estimation":[117],"quality.":[120],"Availability:":[121],"http://www.fmi.ch/groups/functional.genomics/tool.htm":[122],"Contact:":[123],"edward.oakeley@fmi.ch":[124],"Supplementary":[125,127],"information:":[126],"data":[128],"are":[129],"available":[130],"from":[131],"http://www.fmi.ch/groups/functional.genomics/tool-Supp.htm":[132]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
