{"id":"https://openalex.org/W2105247771","doi":"https://doi.org/10.1093/bioinformatics/btm346","title":"Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments","display_name":"Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments","publication_year":2007,"publication_date":"2007-07-11","ids":{"openalex":"https://openalex.org/W2105247771","doi":"https://doi.org/10.1093/bioinformatics/btm346","mag":"2105247771","pmid":"https://pubmed.ncbi.nlm.nih.gov/17626063"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm346","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm346","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/18/2441/49816608/bioinformatics_23_18_2441.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/18/2441/49816608/bioinformatics_23_18_2441.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024093289","display_name":"Jaroslaw Harezlak","orcid":"https://orcid.org/0000-0002-3070-7686"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jaroslaw Harezlak","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020888355","display_name":"Mike Wang","orcid":"https://orcid.org/0000-0001-6487-5912"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Wang","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091331939","display_name":"David C. Christiani","orcid":"https://orcid.org/0000-0002-0301-0242"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Christiani","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030660111","display_name":"Xihong Lin","orcid":"https://orcid.org/0000-0001-7067-7752"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xihong Lin","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health 655 Huntington Avenue Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024093289"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.218,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.77216462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"23","issue":"18","first_page":"2441","last_page":"2448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.6517000198364258,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.6517000198364258,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.34310001134872437,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reproducibility","display_name":"Reproducibility","score":0.7371225357055664},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.597392737865448},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.5133234858512878},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.48879334330558777},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4853426516056061},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.46250030398368835},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38612401485443115},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32474738359451294},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.29943177103996277},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2701425552368164},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22746986150741577},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.17167776823043823},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07793903350830078}],"concepts":[{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.7371225357055664},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.597392737865448},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.5133234858512878},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.48879334330558777},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4853426516056061},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.46250030398368835},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38612401485443115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32474738359451294},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.29943177103996277},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2701425552368164},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22746986150741577},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.17167776823043823},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07793903350830078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm346","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm346","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/18/2441/49816608/bioinformatics_23_18_2441.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17626063","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17626063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm346","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm346","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/18/2441/49816608/bioinformatics_23_18_2441.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6122994909","display_name":null,"funder_award_id":"CA074386","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105247771.pdf","grobid_xml":"https://content.openalex.org/works/W2105247771.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W84108305","https://openalex.org/W137245905","https://openalex.org/W1512882103","https://openalex.org/W1533335653","https://openalex.org/W1582484699","https://openalex.org/W1967102831","https://openalex.org/W1980788421","https://openalex.org/W1982585616","https://openalex.org/W2011436309","https://openalex.org/W2015801127","https://openalex.org/W2025039432","https://openalex.org/W2041282815","https://openalex.org/W2041734434","https://openalex.org/W2073859652","https://openalex.org/W2074089196","https://openalex.org/W2082246284","https://openalex.org/W2084747179","https://openalex.org/W2117098825","https://openalex.org/W2119908867","https://openalex.org/W2126383455","https://openalex.org/W2128432283","https://openalex.org/W2130213158","https://openalex.org/W2133781427","https://openalex.org/W2134389439","https://openalex.org/W2139564441","https://openalex.org/W2164434522","https://openalex.org/W2167244585","https://openalex.org/W2169182264","https://openalex.org/W2493260742","https://openalex.org/W2519438632","https://openalex.org/W3022413497","https://openalex.org/W4233200032","https://openalex.org/W4238717354","https://openalex.org/W4366065112","https://openalex.org/W4376453806","https://openalex.org/W6630520785","https://openalex.org/W6634915427","https://openalex.org/W6669343318","https://openalex.org/W6679212166"],"related_works":["https://openalex.org/W2413717610","https://openalex.org/W1973270181","https://openalex.org/W2417696084","https://openalex.org/W2368782778","https://openalex.org/W2087830269","https://openalex.org/W3106281778","https://openalex.org/W2003643616","https://openalex.org/W638612878","https://openalex.org/W4324138256","https://openalex.org/W2140154150"],"abstract_inverted_index":{"MOTIVATION:":[0],"Mass":[1],"spectrometry":[2],"(MS),":[3],"such":[4,28],"as":[5,115,198],"the":[6,49,60,79,95,100,107,110,116,120,139,142,152,160,166,169,190,195,201],"surface-enhanced":[7],"laser":[8],"desorption":[9],"and":[10,51,71,84,89,134,138,165],"ionization":[11],"time-of-flight":[12],"(SELDI-TOF)":[13],"MS,":[14],"provides":[15],"a":[16,29,104],"potentially":[17],"promising":[18],"proteomic":[19],"technology":[20,30],"for":[21,27,99,128,145,207],"biomarker":[22],"discovery.":[23],"An":[24],"important":[25],"matter":[26],"to":[31,43,47],"be":[32],"used":[33],"routinely":[34],"is":[35,39,157,213],"its":[36],"reproducibility.":[37,147],"It":[38],"of":[40,53,62,78,81,109,132,141,154,168,179,209],"significant":[41],"interest":[42],"develop":[44],"quantitative":[45],"measures":[46],"evaluate":[48],"quality":[50,61,212],"reliability":[52,143,202],"different":[54],"experimental":[55,184],"methods.":[56],"RESULTS:":[57],"We":[58],"compare":[59],"SELDI-TOF":[63,210],"MS":[64],"data":[65,220],"using":[66,189],"unfractionated,":[67],"fractionated":[68],"plasma":[69,180,192],"samples":[70,181,193],"abundant":[72],"protein":[73],"depletion":[74],"methods":[75],"in":[76,122],"terms":[77],"numbers":[80],"detected":[82,156,188],"peaks":[83,155,187],"reliability.":[85],"Several":[86],"statistical":[87],"quality-control":[88],"quality-assessment":[90],"techniques":[91],"are":[92,221],"proposed,":[93],"including":[94],"Graeco-Latin":[96],"square":[97],"design":[98],"sample":[101,162],"allocation":[102],"on":[103],"Protein":[105],"chip,":[106],"use":[108,140,167],"pairwise":[111],"Pearson":[112],"correlation":[113],"coefficient":[114],"similarity":[117,131],"measure":[118],"between":[119],"spectra":[121],"conjunction":[123],"with":[124],"multi-dimensional":[125],"scaling":[126],"(MDS)":[127],"graphically":[129],"evaluating":[130,146],"replicates":[133],"assessing":[135],"outlier":[136],"samples;":[137],"ratio":[144],"Our":[148,205],"results":[149],"show":[150],"that":[151],"number":[153],"similar":[158],"among":[159],"three":[161],"preparation":[163],"technologies,":[164],"Sigma":[170],"multi-removal":[171],"kit":[172],"does":[173],"not":[174],"improve":[175],"peak":[176],"detection.":[177],"Fractionation":[178],"introduces":[182],"more":[183],"variability.":[185],"The":[186],"unfractionated":[191],"have":[194],"highest":[196],"reproducibility":[197],"determined":[199],"by":[200],"ratio.":[203],"AVAILABILITY:":[204],"algorithm":[206],"assessment":[208],"experiment":[211],"available":[214,222],"at":[215,223],"http://www.biostat.harvard.edu/~xlin.":[216],"SUPPLEMENTARY":[217],"INFORMATION:":[218],"Supplementary":[219],"Bioinformatics":[224],"online.":[225]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
