{"id":"https://openalex.org/W2112023359","doi":"https://doi.org/10.1093/bioinformatics/btl464","title":"Regression analysis for comparing protein samples with 16O/18O stable-isotope labeled mass spectrometry","display_name":"Regression analysis for comparing protein samples with 16O/18O stable-isotope labeled mass spectrometry","publication_year":2006,"publication_date":"2006-09-05","ids":{"openalex":"https://openalex.org/W2112023359","doi":"https://doi.org/10.1093/bioinformatics/btl464","mag":"2112023359","pmid":"https://pubmed.ncbi.nlm.nih.gov/16954138"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl464","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl464","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040994175","display_name":"Jeanette E. Eckel\u2010Passow","orcid":"https://orcid.org/0000-0002-6113-1114"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. E. Eckel-Passow","raw_affiliation_strings":["Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu","Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069976109","display_name":"Ann L. Oberg","orcid":"https://orcid.org/0000-0003-2539-9807"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. L. Oberg","raw_affiliation_strings":["Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014433885","display_name":"Terry M. Therneau","orcid":"https://orcid.org/0000-0003-1490-6711"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. M. Therneau","raw_affiliation_strings":["Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058758701","display_name":"Christopher J. Mason","orcid":null},"institutions":[{"id":"https://openalex.org/I2802423016","display_name":"WinnMed","ror":"https://ror.org/02s47w807","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802423016"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. J. Mason","raw_affiliation_strings":["Mayo Proteomics Research Center, Mayo Clinic 2 \u00a0 2 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA"],"affiliations":[{"raw_affiliation_string":"Mayo Proteomics Research Center, Mayo Clinic 2 \u00a0 2 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2802423016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038158795","display_name":"Douglas W. Mahoney","orcid":"https://orcid.org/0000-0001-5144-0645"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. W. Mahoney","raw_affiliation_strings":["Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA#TAB#","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054301416","display_name":"Kenneth L. Johnson","orcid":"https://orcid.org/0000-0002-8267-8047"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2802423016","display_name":"WinnMed","ror":"https://ror.org/02s47w807","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802423016"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. L. Johnson","raw_affiliation_strings":["Mayo Proteomics Research Center, Mayo Clinic 2 \u00a0 2 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA"],"affiliations":[{"raw_affiliation_string":"Mayo Proteomics Research Center, Mayo Clinic 2 \u00a0 2 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2802423016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088395323","display_name":"Janet E. Olson","orcid":"https://orcid.org/0000-0003-4944-7789"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. E. Olson","raw_affiliation_strings":["Division of Epidemiology, Department of Health Sciences Research 1 \u00a0 1 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA"],"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Health Sciences Research 1 \u00a0 1 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110123866","display_name":"H. Robert Bergen","orcid":null},"institutions":[{"id":"https://openalex.org/I2802423016","display_name":"WinnMed","ror":"https://ror.org/02s47w807","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802423016"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. R. Bergen","raw_affiliation_strings":["Mayo Proteomics Research Center, Mayo Clinic 2 \u00a0 2 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA"],"affiliations":[{"raw_affiliation_string":"Mayo Proteomics Research Center, Mayo Clinic 2 \u00a0 2 \u00a0 \u00a0 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2802423016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5040994175"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I5388228"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.2894,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.87401826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"22","first_page":"2739","last_page":"2745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotope","display_name":"Isotope","score":0.7457872629165649},{"id":"https://openalex.org/keywords/stable-isotope-ratio","display_name":"Stable isotope ratio","score":0.7098302245140076},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5819697976112366},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.580478847026825},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.5426642298698425},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.523297131061554},{"id":"https://openalex.org/keywords/abundance","display_name":"Abundance (ecology)","score":0.4492000937461853},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.4358370304107666},{"id":"https://openalex.org/keywords/isotope-analysis","display_name":"Isotope analysis","score":0.4240332245826721},{"id":"https://openalex.org/keywords/multivariable-calculus","display_name":"Multivariable calculus","score":0.4239840805530548},{"id":"https://openalex.org/keywords/natural-abundance","display_name":"Natural abundance","score":0.4220200181007385},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3748074769973755},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.3290629982948303},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.2920732796192169},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.16258221864700317},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14967671036720276},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1280602514743805},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.0818658173084259},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07684153318405151},{"id":"https://openalex.org/keywords/nuclear-physics","display_name":"Nuclear physics","score":0.06312450766563416},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.05873316526412964}],"concepts":[{"id":"https://openalex.org/C164304813","wikidata":"https://www.wikidata.org/wiki/Q25276","display_name":"Isotope","level":2,"score":0.7457872629165649},{"id":"https://openalex.org/C22117777","wikidata":"https://www.wikidata.org/wiki/Q17148629","display_name":"Stable isotope ratio","level":2,"score":0.7098302245140076},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5819697976112366},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.580478847026825},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5426642298698425},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.523297131061554},{"id":"https://openalex.org/C77077793","wikidata":"https://www.wikidata.org/wiki/Q336019","display_name":"Abundance (ecology)","level":2,"score":0.4492000937461853},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.4358370304107666},{"id":"https://openalex.org/C51813073","wikidata":"https://www.wikidata.org/wiki/Q518459","display_name":"Isotope analysis","level":2,"score":0.4240332245826721},{"id":"https://openalex.org/C117312493","wikidata":"https://www.wikidata.org/wiki/Q2035437","display_name":"Multivariable calculus","level":2,"score":0.4239840805530548},{"id":"https://openalex.org/C28271814","wikidata":"https://www.wikidata.org/wiki/Q659662","display_name":"Natural abundance","level":3,"score":0.4220200181007385},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3748074769973755},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3290629982948303},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2920732796192169},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.16258221864700317},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14967671036720276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1280602514743805},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0818658173084259},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07684153318405151},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.06312450766563416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05873316526412964},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007554","descriptor_name":"Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007554","descriptor_name":"Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007554","descriptor_name":"Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btl464","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl464","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16954138","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16954138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306937","display_name":"Fraternal Order of Eagles","ror":"https://ror.org/01er75989"},{"id":"https://openalex.org/F4320308851","display_name":"Lustgarten Foundation","ror":"https://ror.org/030635250"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2006419756","https://openalex.org/W2007843519","https://openalex.org/W2016707540","https://openalex.org/W2028814863","https://openalex.org/W2044655708","https://openalex.org/W2050787616","https://openalex.org/W2069862631","https://openalex.org/W2075060008","https://openalex.org/W2086502504","https://openalex.org/W2091101858","https://openalex.org/W2094078021","https://openalex.org/W2105869274","https://openalex.org/W2111208057","https://openalex.org/W2321741636","https://openalex.org/W2898519191","https://openalex.org/W3146425672","https://openalex.org/W4299837303"],"related_works":["https://openalex.org/W2350271716","https://openalex.org/W2351407506","https://openalex.org/W4386956250","https://openalex.org/W2626327740","https://openalex.org/W2282277134","https://openalex.org/W3195213742","https://openalex.org/W2369397278","https://openalex.org/W2400387859","https://openalex.org/W2914161096","https://openalex.org/W2328891786"],"abstract_inverted_index":{"Using":[0],"stable":[1],"isotopes":[2],"in":[3,42,49,91,123,201],"global":[4],"proteome":[5],"scans,":[6],"labeled":[7,72,145,207,218],"molecules":[8,16,35],"from":[9,17,82,115,180],"one":[10],"sample":[11,19],"are":[12,40,47,136,168,184,213],"pooled":[13],"with":[14,57],"unlabeled":[15,151],"another":[18],"and":[20,46,86],"subsequently":[21],"subjected":[22],"to":[23,138,154,157,186,215],"mass-spectral":[24],"analysis.":[25,130],"Stable-isotope":[26],"methodologies":[27],"make":[28],"use":[29],"of":[30,36,78,93,105,143,190,204],"the":[31,83,88,94,106,116,132,141,144,155,159,164,181,188,191,196,202,209],"fact":[32],"that":[33,74,147],"identical":[34],"different":[37],"stable-isotope":[38,71,206,217],"compositions":[39],"differentiated":[41],"a":[43,50,58,172],"mass":[44,51,60],"spectrometer":[45],"represented":[48],"spectrum":[52],"as":[53,149],"distinct":[54],"isotopic":[55,80],"clusters":[56,81],"known":[59],"shift.":[61],"We":[62,176],"describe":[63],"two":[64,95,117],"multivariable":[65,133,210],"linear":[66],"regression":[67,134,182,211],"models":[68,135,212],"for":[69,101,112,140,163,171,195],"(16)O/(18)O":[70,205],"data":[73],"jointly":[75],"model":[76,183],"pairs":[77],"resolved":[79],"same":[84],"peptide":[85,114,146,152],"quantify":[87,187],"abundance":[89,110,142,193],"present":[90],"each":[92,113],"biological":[96,118],"samples":[97,119],"while":[98],"concurrently":[99],"accounting":[100],"peptide-specific":[102],"incorporation":[103],"rates":[104],"heavy":[107,165],"isotope.":[108],"The":[109],"measure":[111],"is":[120],"then":[121],"used":[122,185],"down-stream":[124],"statistical":[125],"analyses,":[126],"e.g.":[127],"differential":[128],"expression":[129],"Because":[131],"able":[137],"correct":[139],"appear":[148],"an":[150],"due":[153],"inability":[156],"exchange":[158],"natural":[160],"C-terminal":[161],"oxygen":[162],"isotope,":[166],"they":[167],"particularly":[169],"advantageous":[170],"two-step":[173],"digestion/labeling":[174],"procedure.":[175],"discuss":[177],"how":[178],"estimates":[179],"variability":[189],"estimated":[192],"measures":[194],"paired":[197],"samples.":[198],"Although":[199],"discussed":[200],"context":[203],"data,":[208],"generalizable":[214],"other":[216],"technologies.":[219]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}