{"id":"https://openalex.org/W2135347957","doi":"https://doi.org/10.1093/bioinformatics/btl343","title":"Identification of regulatory modules by co-clustering latent variable models: stem cell differentiation","display_name":"Identification of regulatory modules by co-clustering latent variable models: stem cell differentiation","publication_year":2006,"publication_date":"2006-08-09","ids":{"openalex":"https://openalex.org/W2135347957","doi":"https://doi.org/10.1093/bioinformatics/btl343","mag":"2135347957","pmid":"https://pubmed.ncbi.nlm.nih.gov/16899491"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btl343","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl343","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060488559","display_name":"Je\u2010Gun Joung","orcid":"https://orcid.org/0000-0003-2859-1036"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Je-Gun Joung","raw_affiliation_strings":["Center for Bioinformation Technology, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 1 \u00a0 1 \u00a0 \u00a0 Seoul 151-742, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformation Technology, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 1 \u00a0 1 \u00a0 \u00a0 Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053260530","display_name":"Dong\u2010Ho Shin","orcid":"https://orcid.org/0000-0002-7874-5542"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dongho Shin","raw_affiliation_strings":["Research Center for Functional Cellulomics, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 3 \u00a0 3 \u00a0 \u00a0 Seoul 151-742, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Research Center for Functional Cellulomics, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 3 \u00a0 3 \u00a0 \u00a0 Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074990799","display_name":"Rho Hyun Seong","orcid":"https://orcid.org/0000-0001-5699-0718"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Rho Hyun Seong","raw_affiliation_strings":["Research Center for Functional Cellulomics, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 3 \u00a0 3 \u00a0 \u00a0 Seoul 151-742, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Research Center for Functional Cellulomics, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 3 \u00a0 3 \u00a0 \u00a0 Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107826037","display_name":"Byoung\u2010Tak Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byoung-Tak Zhang","raw_affiliation_strings":["Center for Bioinformation Technology, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 1 \u00a0 1 \u00a0 \u00a0 Seoul 151-742, Republic of Korea","School of Computer Science and Engineering, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 2 \u00a0 2 \u00a0 \u00a0 Seoul 151-742, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformation Technology, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 1 \u00a0 1 \u00a0 \u00a0 Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Institute of Molecular Biology and Genetics and Department of Biological Sciences, Seoul National University 2 \u00a0 2 \u00a0 \u00a0 Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074990799","https://openalex.org/A5107826037"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.3246,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.78930902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"22","issue":"16","first_page":"2005","last_page":"2011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.7156693339347839},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7022076845169067},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6772240996360779},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5704056620597839},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5644281506538391},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.521824061870575},{"id":"https://openalex.org/keywords/e2f","display_name":"E2F","score":0.49419906735420227},{"id":"https://openalex.org/keywords/latent-variable","display_name":"Latent variable","score":0.4850980043411255},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.48180192708969116},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4816840589046478},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.45532822608947754},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.43052423000335693},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39824098348617554},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.35184070467948914},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.17846539616584778}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7156693339347839},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7022076845169067},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6772240996360779},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5704056620597839},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5644281506538391},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.521824061870575},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.49419906735420227},{"id":"https://openalex.org/C51167844","wikidata":"https://www.wikidata.org/wiki/Q4422623","display_name":"Latent variable","level":2,"score":0.4850980043411255},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.48180192708969116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4816840589046478},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45532822608947754},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43052423000335693},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39824098348617554},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35184070467948914},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17846539616584778},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btl343","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btl343","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16899491","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16899491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.6299999952316284}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1493217831","https://openalex.org/W1746680969","https://openalex.org/W1846206282","https://openalex.org/W1981860701","https://openalex.org/W1986744382","https://openalex.org/W1996831781","https://openalex.org/W2001627351","https://openalex.org/W2003967338","https://openalex.org/W2014977030","https://openalex.org/W2016536941","https://openalex.org/W2030575711","https://openalex.org/W2036202630","https://openalex.org/W2041532719","https://openalex.org/W2061427780","https://openalex.org/W2083483484","https://openalex.org/W2107575419","https://openalex.org/W2111142380","https://openalex.org/W2119739306","https://openalex.org/W2120820769","https://openalex.org/W2124285724","https://openalex.org/W2130158951","https://openalex.org/W2132226460","https://openalex.org/W2134731454","https://openalex.org/W2136145671","https://openalex.org/W2144544802","https://openalex.org/W2144740486","https://openalex.org/W2144791796","https://openalex.org/W2150926065","https://openalex.org/W2166811005","https://openalex.org/W2166898290","https://openalex.org/W2171030481","https://openalex.org/W2171353991","https://openalex.org/W2188067502","https://openalex.org/W2237430945","https://openalex.org/W4293196852","https://openalex.org/W6629329278","https://openalex.org/W6638896522","https://openalex.org/W6842402754"],"related_works":["https://openalex.org/W2088084745","https://openalex.org/W2154273201","https://openalex.org/W2125072003","https://openalex.org/W2115862144","https://openalex.org/W2029631901","https://openalex.org/W2027753433","https://openalex.org/W1999523595","https://openalex.org/W2150245109","https://openalex.org/W4225694350","https://openalex.org/W3192072182"],"abstract_inverted_index":{"We":[0],"used":[1],"a":[2,82],"list":[3],"of":[4,9,53,86],"genes":[5,64],"enriched":[6],"in":[7],"each":[8,30],"21":[10],"stem":[11,31,55,87],"cell":[12,32,56,88],"subpopulations,":[13],"and":[14,36,42,44,90],"their":[15],"upstream":[16],"genomic":[17],"sequences.":[18],"The":[19],"LVM-based":[20],"study":[21,85],"allowed":[22],"us":[23],"to":[24,78,94],"uncover":[25],"the":[26,39,47,51,54,62,70],"regulatory":[27],"modules":[28],"for":[29,38,46],"cluster,":[33],"e.g.":[34],"GABP":[35],"E2F":[37],"proliferation":[40],"phase,":[41],"Ap2alpha":[43],"Ap2gamma":[45],"quiescence":[48],"phase.":[49],"Furthermore,":[50],"identities":[52],"clusters":[57],"were":[58,66],"well":[59],"revealed":[60],"by":[61,69],"constituent":[63],"that":[65],"directly":[67],"targeted":[68],"modules.":[71],"Consequently,":[72],"our":[73],"analytical":[74],"framework":[75],"was":[76],"demonstrated":[77],"be":[79,92],"useful":[80],"through":[81],"detailed":[83],"case":[84],"differentiation":[89],"can":[91],"applied":[93],"problems":[95],"with":[96],"similar":[97],"characteristics.":[98]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}