{"id":"https://openalex.org/W2134880148","doi":"https://doi.org/10.1093/bioinformatics/btk028","title":"Inferring global levels of alternative splicing isoforms using a generative model of microarray data","display_name":"Inferring global levels of alternative splicing isoforms using a generative model of microarray data","publication_year":2006,"publication_date":"2006-01-10","ids":{"openalex":"https://openalex.org/W2134880148","doi":"https://doi.org/10.1093/bioinformatics/btk028","mag":"2134880148","pmid":"https://pubmed.ncbi.nlm.nih.gov/16403798"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btk028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk028","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/5/606/48840615/bioinformatics_22_5_606.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/22/5/606/48840615/bioinformatics_22_5_606.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056025103","display_name":"Ofer Shai","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ofer Shai","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Toronto 1 \u00a0 1 \u00a0 \u00a0 Toronto, Canada, M5S 3G8"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Toronto 1 \u00a0 1 \u00a0 \u00a0 Toronto, Canada, M5S 3G8","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035010657","display_name":"Quaid Morris","orcid":"https://orcid.org/0000-0002-2760-6999"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Quaid D. Morris","raw_affiliation_strings":["Banting and Best Department of Medical Research, University of Toronto 2 \u00a0 2 \u00a0 \u00a0 Toronto, Canada, M5G 1L6"],"affiliations":[{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto 2 \u00a0 2 \u00a0 \u00a0 Toronto, Canada, M5G 1L6","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032292978","display_name":"Benjamin J. Blencowe","orcid":"https://orcid.org/0000-0002-4461-0340"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benjamin J. Blencowe","raw_affiliation_strings":["Banting and Best Department of Medical Research, University of Toronto 2 \u00a0 2 \u00a0 \u00a0 Toronto, Canada, M5G 1L6"],"affiliations":[{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto 2 \u00a0 2 \u00a0 \u00a0 Toronto, Canada, M5G 1L6","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003361977","display_name":"Brendan J. Frey","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brendan J. Frey","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Toronto 1 \u00a0 1 \u00a0 \u00a0 Toronto, Canada, M5S 3G8"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Toronto 1 \u00a0 1 \u00a0 \u00a0 Toronto, Canada, M5S 3G8","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056025103"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.0335,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.96159904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"5","first_page":"606","last_page":"613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.6541889309883118},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6502386927604675},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.6397224068641663},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.6379361748695374},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.6376433372497559},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6205479502677917},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6150036454200745},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.5789768695831299},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5235098004341125},{"id":"https://openalex.org/keywords/exon-skipping","display_name":"Exon skipping","score":0.5143035650253296},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.471962571144104},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4118328094482422},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35160496830940247},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.33572614192962646},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.09564819931983948}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6541889309883118},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6502386927604675},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6397224068641663},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6379361748695374},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6376433372497559},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6205479502677917},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6150036454200745},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5789768695831299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5235098004341125},{"id":"https://openalex.org/C2778776201","wikidata":"https://www.wikidata.org/wiki/Q3474283","display_name":"Exon skipping","level":5,"score":0.5143035650253296},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.471962571144104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4118328094482422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35160496830940247},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33572614192962646},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.09564819931983948},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btk028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk028","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/5/606/48840615/bioinformatics_22_5_606.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16403798","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16403798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btk028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btk028","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/22/5/606/48840615/bioinformatics_22_5_606.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134880148.pdf","grobid_xml":"https://content.openalex.org/works/W2134880148.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1505825270","https://openalex.org/W1523309563","https://openalex.org/W1746680969","https://openalex.org/W1972985327","https://openalex.org/W1985094434","https://openalex.org/W1986113553","https://openalex.org/W1993780097","https://openalex.org/W2003605043","https://openalex.org/W2008836144","https://openalex.org/W2027915529","https://openalex.org/W2030913408","https://openalex.org/W2037139598","https://openalex.org/W2038617558","https://openalex.org/W2040482262","https://openalex.org/W2048618925","https://openalex.org/W2049633694","https://openalex.org/W2063318299","https://openalex.org/W2091765691","https://openalex.org/W2096940705","https://openalex.org/W2097694304","https://openalex.org/W2099065829","https://openalex.org/W2103160981","https://openalex.org/W2106315526","https://openalex.org/W2114551781","https://openalex.org/W2118823143","https://openalex.org/W2122598723","https://openalex.org/W2125487242","https://openalex.org/W2134208113","https://openalex.org/W2136294994","https://openalex.org/W2158085979","https://openalex.org/W2158463967","https://openalex.org/W2165954869","https://openalex.org/W2172189627","https://openalex.org/W2465591554","https://openalex.org/W2567948266","https://openalex.org/W3129711340","https://openalex.org/W4250143236","https://openalex.org/W6630361531","https://openalex.org/W6631292434"],"related_works":["https://openalex.org/W1536722219","https://openalex.org/W1971329594","https://openalex.org/W2411269138","https://openalex.org/W2163545200","https://openalex.org/W2160130936","https://openalex.org/W2412120523","https://openalex.org/W170658859","https://openalex.org/W2490137852","https://openalex.org/W3023720143","https://openalex.org/W4310366902"],"abstract_inverted_index":{"http://www.psi.toronto.edu/GenASAP.":[0]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}