{"id":"https://openalex.org/W2126193532","doi":"https://doi.org/10.1093/bioinformatics/bti563","title":"TICO: a tool for improving predictions of prokaryotic translation initiation sites","display_name":"TICO: a tool for improving predictions of prokaryotic translation initiation sites","publication_year":2005,"publication_date":"2005-06-30","ids":{"openalex":"https://openalex.org/W2126193532","doi":"https://doi.org/10.1093/bioinformatics/bti563","mag":"2126193532","pmid":"https://pubmed.ncbi.nlm.nih.gov/15994191"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bti563","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti563","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/17/3568/48981059/bioinformatics_21_17_3568.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/21/17/3568/48981059/bioinformatics_21_17_3568.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109360409","display_name":"M. Tech","orcid":null},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"M. Tech","raw_affiliation_strings":["Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany. maike@gobics.de","Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany"],"affiliations":[{"raw_affiliation_string":"Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany. maike@gobics.de","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076705834","display_name":"Nico Pfeifer","orcid":"https://orcid.org/0000-0002-4647-8566"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Pfeifer","raw_affiliation_strings":["Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany"],"affiliations":[{"raw_affiliation_string":"Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024220352","display_name":"Burkhard Morgenstern","orcid":"https://orcid.org/0000-0002-7431-2862"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Morgenstern","raw_affiliation_strings":["Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany"],"affiliations":[{"raw_affiliation_string":"Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030195753","display_name":"Peter Meinicke","orcid":"https://orcid.org/0009-0002-2228-3403"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Meinicke","raw_affiliation_strings":["Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany"],"affiliations":[{"raw_affiliation_string":"Abteilung Bioinformatik, Institut f\u00fcr Mikrobiologie und Genetik, Georg-August-Universit\u00e4t G\u00f6ttingen  Goldschmidtstrasse 1, 37077 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109360409"],"corresponding_institution_ids":["https://openalex.org/I74656192"],"apc_list":null,"apc_paid":null,"fwci":1.5999,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.82223098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"17","first_page":"3568","last_page":"3569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.7800868153572083},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7579735517501831},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.6521300077438354},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5460690259933472},{"id":"https://openalex.org/keywords/web-site","display_name":"Web site","score":0.4846566319465637},{"id":"https://openalex.org/keywords/eukaryotic-translation","display_name":"Eukaryotic translation","score":0.45758262276649475},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4087749719619751},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37625354528427124},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3252674639225006},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19599682092666626},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1600891351699829},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12638017535209656},{"id":"https://openalex.org/keywords/parallel-computing","display_name":"Parallel computing","score":0.10873177647590637},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.1045880913734436},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.07788053154945374}],"concepts":[{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.7800868153572083},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7579735517501831},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.6521300077438354},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5460690259933472},{"id":"https://openalex.org/C2984519610","wikidata":"https://www.wikidata.org/wiki/Q35127","display_name":"Web site","level":3,"score":0.4846566319465637},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.45758262276649475},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4087749719619751},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37625354528427124},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3252674639225006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19599682092666626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1600891351699829},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12638017535209656},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.10873177647590637},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.1045880913734436},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.07788053154945374},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018387","descriptor_name":"Codon, Initiator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018387","descriptor_name":"Codon, Initiator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018387","descriptor_name":"Codon, Initiator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bti563","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti563","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/17/3568/48981059/bioinformatics_21_17_3568.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:15994191","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15994191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bti563","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bti563","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/21/17/3568/48981059/bioinformatics_21_17_3568.pdf","source":{"id":"https://openalex.org/S4210188263","display_name":"Computer applications in the biosciences","issn_l":"0266-7061","issn":["0266-7061","1460-2059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126193532.pdf","grobid_xml":"https://content.openalex.org/works/W2126193532.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1809097252","https://openalex.org/W2018962053","https://openalex.org/W2026570450","https://openalex.org/W2034829167","https://openalex.org/W2099401974","https://openalex.org/W2106090237","https://openalex.org/W2133253129","https://openalex.org/W2163023575","https://openalex.org/W2168846269","https://openalex.org/W2170488656"],"related_works":["https://openalex.org/W4252337189","https://openalex.org/W3002947890","https://openalex.org/W2503502284","https://openalex.org/W2804364458","https://openalex.org/W4298130764","https://openalex.org/W2132641928","https://openalex.org/W2901430522","https://openalex.org/W4283746337","https://openalex.org/W1590929635","https://openalex.org/W2059998368"],"abstract_inverted_index":{"maike@gobics.de":[0]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}