{"id":"https://openalex.org/W7135371652","doi":"https://doi.org/10.1093/bioinformatics/btag127","title":"Competing subclones and fitness diversity shape tumor evolution across cancer types","display_name":"Competing subclones and fitness diversity shape tumor evolution across cancer types","publication_year":2026,"publication_date":"2026-02-28","ids":{"openalex":"https://openalex.org/W7135371652","doi":"https://doi.org/10.1093/bioinformatics/btag127","pmid":"https://pubmed.ncbi.nlm.nih.gov/41826799"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btag127","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag127","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bioinformatics/btag127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hai Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hai Chen","raw_affiliation_strings":["Biodesign Institute, Arizona State University , Tempe, AZ 85281,","College of Health Solutions, Arizona State University , Phoenix, AZ 85004,","Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,"],"affiliations":[{"raw_affiliation_string":"Biodesign Institute, Arizona State University , Tempe, AZ 85281,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ 85004,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035241169","display_name":"Jingmin Shu","orcid":null},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingmin Shu","raw_affiliation_strings":["Biodesign Institute, Arizona State University , Tempe, AZ 85281,","College of Health Solutions, Arizona State University , Phoenix, AZ 85004,"],"affiliations":[{"raw_affiliation_string":"Biodesign Institute, Arizona State University , Tempe, AZ 85281,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ 85004,","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055198127","display_name":"Rekha Mudappathi","orcid":"https://orcid.org/0000-0001-7965-0919"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rekha Mudappathi","raw_affiliation_strings":["Biodesign Institute, Arizona State University , Tempe, AZ 85281,","College of Health Solutions, Arizona State University , Phoenix, AZ 85004,","Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,"],"affiliations":[{"raw_affiliation_string":"Biodesign Institute, Arizona State University , Tempe, AZ 85281,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ 85004,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044782311","display_name":"Elaine Li","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Li","raw_affiliation_strings":["Emory University , Atlanta, GA 30322,"],"affiliations":[{"raw_affiliation_string":"Emory University , Atlanta, GA 30322,","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016131945","display_name":"Panwen Wang","orcid":"https://orcid.org/0000-0002-4614-8970"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panwen Wang","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,"],"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088762998","display_name":"L. Bergsagel","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leif Bergsagel","raw_affiliation_strings":["Mayo Clinic Comprehensive Cancer Center, , Scottsdale, AZ 85054,"],"affiliations":[{"raw_affiliation_string":"Mayo Clinic Comprehensive Cancer Center, , Scottsdale, AZ 85054,","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129230219","display_name":"Ping Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Yang","raw_affiliation_strings":["Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,"],"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic , Scottsdale, AZ 85259,","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091782524","display_name":"Z Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhifu Sun","raw_affiliation_strings":["Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN 55905,"],"affiliations":[{"raw_affiliation_string":"Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic , Rochester, MN 55905,","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121807655","display_name":"Logan Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan Zhao","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Mayo Clinic , Scottsdale, AZ 85259,"],"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Mayo Clinic , Scottsdale, AZ 85259,","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100667014","display_name":"Chao Shi","orcid":"https://orcid.org/0000-0002-3808-8699"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changxin Shi","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Mayo Clinic , Scottsdale, AZ 85259,"],"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Mayo Clinic , Scottsdale, AZ 85259,","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129198097","display_name":"Jeffrey P Townsend","orcid":null},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210117499","display_name":"Yale New Haven Health System","ror":"https://ror.org/01s1hsq14","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117499"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey P Townsend","raw_affiliation_strings":["Department of Biostatistics, Yale School of Public Health , New Haven, CT 06520,","Department of Ecology and Evolutionary Biology, Yale University , New Haven, CT 06520,","Program in Computational Biology and Biomedical Informatics, Yale University , New Haven, CT 06520,","Yale Cancer Center, Yale University , New Haven, CT 06519,"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Yale School of Public Health , New Haven, CT 06520,","institution_ids":["https://openalex.org/I4210117499","https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Program in Computational Biology and Biomedical Informatics, Yale University , New Haven, CT 06520,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center, Yale University , New Haven, CT 06519,","institution_ids":["https://openalex.org/I2802730090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062132898","display_name":"Carlo C. Maley","orcid":"https://orcid.org/0000-0002-0745-7076"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo Maley","raw_affiliation_strings":["Arizona Cancer Evolution Center, Arizona State University , Tempe, AZ 85281,","Biodesign Institute, Arizona State University , Tempe, AZ 85281,"],"affiliations":[{"raw_affiliation_string":"Arizona Cancer Evolution Center, Arizona State University , Tempe, AZ 85281,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Biodesign Institute, Arizona State University , Tempe, AZ 85281,","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129121811","display_name":"Li Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Biodesign Institute, Arizona State University , Tempe, AZ 85281,","College of Health Solutions, Arizona State University , Phoenix, AZ 85004,"],"affiliations":[{"raw_affiliation_string":"Biodesign Institute, Arizona State University , Tempe, AZ 85281,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ 85004,","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I55732556"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58876326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6046000123023987},{"id":"https://openalex.org/keywords/diversity","display_name":"Diversity (politics)","score":0.5728999972343445},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"Genetic diversity","score":0.33169999718666077},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.3109999895095825},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.30640000104904175},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.3003000020980835}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7027000188827515},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6046000123023987},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.5728999972343445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5424000024795532},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5371000170707703},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3822000026702881},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.33169999718666077},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3109999895095825},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.30640000104904175},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.2800000011920929},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26600000262260437},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.257099986076355},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btag127","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag127","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41826799","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41826799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:13025073","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13025073/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btag127","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btag127","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6081113815307617}],"awards":[{"id":"https://openalex.org/G2956415725","display_name":null,"funder_award_id":"R01LM013438","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1809016129","https://openalex.org/W1975574047","https://openalex.org/W1980714336","https://openalex.org/W1985987855","https://openalex.org/W1994777972","https://openalex.org/W2001258296","https://openalex.org/W2009720434","https://openalex.org/W2010875436","https://openalex.org/W2066523597","https://openalex.org/W2073294762","https://openalex.org/W2124531484","https://openalex.org/W2137547257","https://openalex.org/W2260951263","https://openalex.org/W2292534871","https://openalex.org/W2298622237","https://openalex.org/W2521492299","https://openalex.org/W2551911481","https://openalex.org/W2565834876","https://openalex.org/W2587862832","https://openalex.org/W2606495925","https://openalex.org/W2609243345","https://openalex.org/W2611387862","https://openalex.org/W2624271517","https://openalex.org/W2901331509","https://openalex.org/W2919337517","https://openalex.org/W2950945543","https://openalex.org/W2951391875","https://openalex.org/W2951660832","https://openalex.org/W2952001873","https://openalex.org/W2952030916","https://openalex.org/W2998184281","https://openalex.org/W3004480399","https://openalex.org/W3004647847","https://openalex.org/W3005304804","https://openalex.org/W3027286012","https://openalex.org/W3053264094","https://openalex.org/W3096112873","https://openalex.org/W3101619682","https://openalex.org/W3107501753","https://openalex.org/W3109203717","https://openalex.org/W3119672763","https://openalex.org/W3161513587","https://openalex.org/W4200252079","https://openalex.org/W4200571264","https://openalex.org/W4225293827","https://openalex.org/W4225376662","https://openalex.org/W4283383282","https://openalex.org/W4286007893","https://openalex.org/W4293425839","https://openalex.org/W4324046169","https://openalex.org/W4361214692","https://openalex.org/W4386279461","https://openalex.org/W4387009982","https://openalex.org/W4387215763","https://openalex.org/W4393858351","https://openalex.org/W4394927009","https://openalex.org/W4400325786","https://openalex.org/W4403921015"],"related_works":[],"abstract_inverted_index":{"R":[0],"implementation":[1],"of":[2],"TEATIME":[3],"is":[4],"available":[5],"on":[6],"GitHub":[7],"(https://github.com/liliulab/TEATIME)":[8],"and":[9],"Zenodo":[10],"(https://zenodo.org/records/17422174).":[11]},"counts_by_year":[],"updated_date":"2026-04-17T18:11:37.981687","created_date":"2026-03-15T00:00:00"}