{"id":"https://openalex.org/W4382502596","doi":"https://doi.org/10.1093/bioinformatics/btad417","title":"Information-incorporated sparse convex clustering for disease subtyping","display_name":"Information-incorporated sparse convex clustering for disease subtyping","publication_year":2023,"publication_date":"2023-06-29","ids":{"openalex":"https://openalex.org/W4382502596","doi":"https://doi.org/10.1093/bioinformatics/btad417","mag":"37382570"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btad417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad417","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/7/btad417/50843006/btad417.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/39/7/btad417/50843006/btad417.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100419402","display_name":"Xiaoyu Zhang","orcid":"https://orcid.org/0000-0002-2555-0311"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaoyu Zhang","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health , Boston, MA 02118, United States"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health , Boston, MA 02118, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082644230","display_name":"Ching\u2010Ti Liu","orcid":"https://orcid.org/0000-0002-0703-0742"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching-Ti Liu","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health , Boston, MA 02118, United States"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health , Boston, MA 02118, United States","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100419402"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.3045,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63147355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"39","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10637","display_name":"Advanced Clustering Algorithms Research","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subtyping","display_name":"Subtyping","score":0.8284313678741455},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.8243654370307922},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.720781683921814},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6004288196563721},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.571866512298584},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5050588250160217},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.49147236347198486},{"id":"https://openalex.org/keywords/consensus-clustering","display_name":"Consensus clustering","score":0.4405117928981781},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.36253535747528076},{"id":"https://openalex.org/keywords/cure-data-clustering-algorithm","display_name":"CURE data clustering algorithm","score":0.3004935681819916},{"id":"https://openalex.org/keywords/correlation-clustering","display_name":"Correlation clustering","score":0.2503111660480499},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10132935643196106}],"concepts":[{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.8284313678741455},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.8243654370307922},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.720781683921814},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6004288196563721},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.571866512298584},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5050588250160217},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.49147236347198486},{"id":"https://openalex.org/C186767784","wikidata":"https://www.wikidata.org/wiki/Q5162841","display_name":"Consensus clustering","level":5,"score":0.4405117928981781},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.36253535747528076},{"id":"https://openalex.org/C33704608","wikidata":"https://www.wikidata.org/wiki/Q5014717","display_name":"CURE data clustering algorithm","level":4,"score":0.3004935681819916},{"id":"https://openalex.org/C94641424","wikidata":"https://www.wikidata.org/wiki/Q5172845","display_name":"Correlation clustering","level":3,"score":0.2503111660480499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10132935643196106},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btad417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad417","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/7/btad417/50843006/btad417.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"mag:37382570","is_oa":false,"landing_page_url":"https://elib.dlr.de/34261/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10329496","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10329496","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10329496/pdf/btad417.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btad417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btad417","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/39/7/btad417/50843006/btad417.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6100000143051147,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1458435566","display_name":null,"funder_award_id":"R01DK122503","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1632558800","display_name":null,"funder_award_id":"R01AR072199","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G197008112","display_name":null,"funder_award_id":"NIDDK","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2175624253","display_name":null,"funder_award_id":"DK078616","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3298056745","display_name":null,"funder_award_id":"R01HL","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3513984038","display_name":null,"funder_award_id":"NIH/NIAMS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3530239307","display_name":null,"funder_award_id":"NHLBI","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3800257164","display_name":null,"funder_award_id":"R01DK078616","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3962690842","display_name":null,"funder_award_id":"AR072199","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4102820520","display_name":null,"funder_award_id":"R01DK078616","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4110762795","display_name":null,"funder_award_id":"R01DK122503","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4919155732","display_name":null,"funder_award_id":"DK078616","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4924225925","display_name":null,"funder_award_id":"AR072199","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5167176907","display_name":null,"funder_award_id":"R01HL151855","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5397575833","display_name":null,"funder_award_id":"DK122503","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5553995990","display_name":null,"funder_award_id":"NIH/NIDDK","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6164752196","display_name":null,"funder_award_id":"DK078616","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6633336419","display_name":null,"funder_award_id":"HL151855","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G744420836","display_name":null,"funder_award_id":"NIH/NIAMS","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7445402995","display_name":null,"funder_award_id":"NHLBI,","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7713658645","display_name":null,"funder_award_id":"R01DK122503","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G805890577","display_name":null,"funder_award_id":"R01HL151855","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8272558074","display_name":null,"funder_award_id":"R01AR072199","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4382502596.pdf","grobid_xml":"https://content.openalex.org/works/W4382502596.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1747816738","https://openalex.org/W1798009377","https://openalex.org/W1970986119","https://openalex.org/W1976564639","https://openalex.org/W1991509879","https://openalex.org/W1992929897","https://openalex.org/W2011490263","https://openalex.org/W2018116321","https://openalex.org/W2023461603","https://openalex.org/W2025729801","https://openalex.org/W2026574448","https://openalex.org/W2033775272","https://openalex.org/W2044702943","https://openalex.org/W2044729876","https://openalex.org/W2048178552","https://openalex.org/W2071949631","https://openalex.org/W2095763169","https://openalex.org/W2096283457","https://openalex.org/W2097255042","https://openalex.org/W2097413644","https://openalex.org/W2108516575","https://openalex.org/W2109363337","https://openalex.org/W2109553965","https://openalex.org/W2116071996","https://openalex.org/W2123537497","https://openalex.org/W2128985829","https://openalex.org/W2132619562","https://openalex.org/W2140514146","https://openalex.org/W2147246240","https://openalex.org/W2163826318","https://openalex.org/W2166624956","https://openalex.org/W2259802687","https://openalex.org/W2298455674","https://openalex.org/W2560367415","https://openalex.org/W2758889181","https://openalex.org/W2905429904","https://openalex.org/W2910543001","https://openalex.org/W2949561674","https://openalex.org/W2962943190","https://openalex.org/W2963032456","https://openalex.org/W2995382159","https://openalex.org/W3004574547","https://openalex.org/W3081722047","https://openalex.org/W3090613431","https://openalex.org/W3104808334","https://openalex.org/W3104927725","https://openalex.org/W3116273372","https://openalex.org/W3127542726","https://openalex.org/W3148595015","https://openalex.org/W3192786952","https://openalex.org/W4200486401","https://openalex.org/W4235169531","https://openalex.org/W4287508468","https://openalex.org/W4321605231","https://openalex.org/W6771477569"],"related_works":["https://openalex.org/W2380784125","https://openalex.org/W2810025138","https://openalex.org/W1997711767","https://openalex.org/W4387885766","https://openalex.org/W2765894738","https://openalex.org/W2111827030","https://openalex.org/W2139280638","https://openalex.org/W1574003721","https://openalex.org/W2406185607","https://openalex.org/W4237106426"],"abstract_inverted_index":{"Abstract":[0],"Motivation":[1],"Heterogeneity":[2],"in":[3,9,97,195],"human":[4],"diseases":[5,32],"presents":[6],"clinical":[7],"challenges":[8],"accurate":[10,185],"disease":[11,35,54,95,123,186],"characterization":[12],"and":[13,33,125,174,188,201,219,223],"treatment.":[14],"Recently":[15],"available":[16,228],"high":[17],"throughput":[18],"multi-omics":[19,137],"data":[20,46,197],"may":[21,50],"offer":[22],"a":[23,82,117],"great":[24],"opportunity":[25],"to":[26,89,91,121,153],"explore":[27],"the":[28,39,57,70,92,101,105,109,150,155,180],"underlying":[29],"mechanisms":[30],"of":[31,149,157,199],"improve":[34,122],"heterogeneity":[36],"assessment":[37],"throughout":[38],"treatment":[40],"course.":[41],"In":[42,178,206],"addition,":[43,179],"increasingly":[44],"accumulated":[45],"from":[47,112],"existing":[48,58,110],"literature":[49],"be":[51],"informative":[52],"about":[53],"subtyping.":[55],"However,":[56],"clustering":[59,83,165,212],"procedures,":[60],"such":[61,135,167],"as":[62,136,168],"Sparse":[63,86,171],"Convex":[64,87],"Clustering":[65],"(SCC),":[66],"cannot":[67],"directly":[68],"utilize":[69],"prior":[71,151],"information":[72,111,152],"even":[73],"though":[74],"SCC":[75],"produces":[76],"stable":[77],"clusters.":[78],"Results":[79],"We":[80,139],"develop":[81],"procedure,":[84],"information-incorporated":[85,211],"Clustering,":[88],"respond":[90],"need":[93],"for":[94,192],"subtyping":[96,124],"precision":[98],"medicine.":[99],"Utilizing":[100],"text":[102],"mining":[103],"approach,":[104],"proposed":[106,129,161,181],"method":[107,130,162,182],"leverages":[108],"previously":[113],"published":[114],"studies":[115,142,194],"through":[116],"group":[118],"lasso":[119],"penalty":[120],"biomarker":[126],"identification.":[127],"The":[128,160,225],"allows":[131,215],"taking":[132],"heterogeneous":[133],"information,":[134],"data.":[138,205],"conduct":[140],"simulation":[141],"under":[143],"several":[144],"scenarios":[145],"with":[146],"various":[147],"accuracy":[148],"evaluate":[154],"performance":[156],"our":[158],"method.":[159],"outperforms":[163],"other":[164],"methods,":[166],"SCC,":[169],"K-means,":[170,172],"iCluster+,":[173],"Bayesian":[175],"Consensus":[176],"Clustering.":[177],"generates":[183],"more":[184],"subtypes":[187],"identifies":[189],"important":[190],"biomarkers":[191],"future":[193],"real":[196],"analysis":[198],"breast":[200],"lung":[202],"cancer-related":[203],"omics":[204],"conclusion,":[207],"we":[208],"present":[209],"an":[210],"procedure":[213],"that":[214],"coherent":[216],"pattern":[217],"discovery":[218],"feature":[220],"selection.":[221],"Availability":[222],"implementation":[224],"code":[226],"is":[227],"upon":[229],"request.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2023-06-30T00:00:00"}
