{"id":"https://openalex.org/W4224309355","doi":"https://doi.org/10.1093/bioinformatics/btac276","title":"Kernel-based hierarchical structural component models for pathway analysis","display_name":"Kernel-based hierarchical structural component models for pathway analysis","publication_year":2022,"publication_date":"2022-04-20","ids":{"openalex":"https://openalex.org/W4224309355","doi":"https://doi.org/10.1093/bioinformatics/btac276","pmid":"https://pubmed.ncbi.nlm.nih.gov/35460238"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btac276","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac276","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/11/3078/43857824/btac276.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/38/11/3078/43857824/btac276.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077229668","display_name":"Suhyun Hwangbo","orcid":"https://orcid.org/0000-0001-9294-1518"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suhyun Hwangbo","raw_affiliation_strings":["Department of Genomic Medicine, Seoul National University Hospital , Seoul 03080, Korea","Interdisciplinary Program in Bioinformatics, Seoul National University , Seoul 151-747, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, Seoul National University Hospital , Seoul 03080, Korea","institution_ids":["https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, Seoul National University , Seoul 151-747, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076575654","display_name":"Sungyoung Lee","orcid":"https://orcid.org/0000-0003-3458-1440"},"institutions":[{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I28777354","display_name":"Sejong University","ror":"https://ror.org/00aft1q37","country_code":"KR","type":"education","lineage":["https://openalex.org/I28777354"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungyoung Lee","raw_affiliation_strings":["Department of Genomic Medicine, Seoul National University Hospital , Seoul 03080, Korea","Department of Mathematics and Statistics, Sejong University , Sejong 05006, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, Seoul National University Hospital , Seoul 03080, Korea","institution_ids":["https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, Sejong University , Sejong 05006, Korea","institution_ids":["https://openalex.org/I28777354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034909134","display_name":"Seungyeoun Lee","orcid":"https://orcid.org/0000-0001-7941-8933"},"institutions":[{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I28777354","display_name":"Sejong University","ror":"https://ror.org/00aft1q37","country_code":"KR","type":"education","lineage":["https://openalex.org/I28777354"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seungyeoun Lee","raw_affiliation_strings":["Department of Genomic Medicine, Seoul National University Hospital , Seoul 03080, Korea","Department of Mathematics and Statistics, Sejong University , Sejong 05006, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Genomic Medicine, Seoul National University Hospital , Seoul 03080, Korea","institution_ids":["https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, Sejong University , Sejong 05006, Korea","institution_ids":["https://openalex.org/I28777354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015487584","display_name":"Heungsun Hwang","orcid":"https://orcid.org/0000-0002-5057-7479"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Heungsun Hwang","raw_affiliation_strings":["Department of Psychology, McGill University , Montreal, QC H3A 1B1, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Psychology, McGill University , Montreal, QC H3A 1B1, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681110","display_name":"Inyoung Kim","orcid":"https://orcid.org/0000-0002-5975-4582"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inyoung Kim","raw_affiliation_strings":["Department of Statistics, Virginia Tech. , Blacksburg, VA 24060, USA"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Virginia Tech. , Blacksburg, VA 24060, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643662","display_name":"Taesung Park","orcid":"https://orcid.org/0000-0002-8294-590X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Taesung Park","raw_affiliation_strings":["Department of Statistics, Seoul National University , Seoul 151-747, Korea","Interdisciplinary Program in Bioinformatics, Seoul National University , Seoul 151-747, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University , Seoul 151-747, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, Seoul National University , Seoul 151-747, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100643662"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6076,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.63559873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"38","issue":"11","first_page":"3078","last_page":"3086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.7115685343742371},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6726536750793457},{"id":"https://openalex.org/keywords/kernel-method","display_name":"Kernel method","score":0.5715351700782776},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49533382058143616},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4900907278060913},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.48692476749420166},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"Pathway analysis","score":0.484594464302063},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.43749773502349854},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4232417345046997},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33453720808029175},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33233219385147095},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2220974862575531},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.16610252857208252},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14596843719482422},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07893785834312439}],"concepts":[{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.7115685343742371},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6726536750793457},{"id":"https://openalex.org/C122280245","wikidata":"https://www.wikidata.org/wiki/Q620622","display_name":"Kernel method","level":3,"score":0.5715351700782776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49533382058143616},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4900907278060913},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.48692476749420166},{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.484594464302063},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.43749773502349854},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4232417345046997},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33453720808029175},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33233219385147095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2220974862575531},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.16610252857208252},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14596843719482422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07893785834312439},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btac276","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac276","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/11/3078/43857824/btac276.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35460238","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35460238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:s-space.snu.ac.kr:10371/185690","is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/185690","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btac276","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btac276","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/38/11/3078/43857824/btac276.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224309355.pdf","grobid_xml":"https://content.openalex.org/works/W4224309355.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1839879947","https://openalex.org/W1972584665","https://openalex.org/W1982127745","https://openalex.org/W1983457010","https://openalex.org/W2007897985","https://openalex.org/W2015150982","https://openalex.org/W2015904350","https://openalex.org/W2016224303","https://openalex.org/W2018107887","https://openalex.org/W2031893281","https://openalex.org/W2038691059","https://openalex.org/W2039140169","https://openalex.org/W2058148991","https://openalex.org/W2063441242","https://openalex.org/W2072970694","https://openalex.org/W2080712240","https://openalex.org/W2083157509","https://openalex.org/W2097834668","https://openalex.org/W2108299701","https://openalex.org/W2108925261","https://openalex.org/W2110300022","https://openalex.org/W2130410032","https://openalex.org/W2136582936","https://openalex.org/W2136850689","https://openalex.org/W2145265944","https://openalex.org/W2145448069","https://openalex.org/W2154164391","https://openalex.org/W2162366839","https://openalex.org/W2163953557","https://openalex.org/W2167540852","https://openalex.org/W2179438025","https://openalex.org/W2192367232","https://openalex.org/W2224812643","https://openalex.org/W2515980744","https://openalex.org/W2590751720","https://openalex.org/W2765998662","https://openalex.org/W2767092306","https://openalex.org/W2769127580","https://openalex.org/W2782404771","https://openalex.org/W2795123374","https://openalex.org/W2801474342","https://openalex.org/W2889999317","https://openalex.org/W2913283787","https://openalex.org/W2946725248","https://openalex.org/W2970460758","https://openalex.org/W2974361058","https://openalex.org/W2977595350","https://openalex.org/W2984473439","https://openalex.org/W2988671424","https://openalex.org/W2989930462","https://openalex.org/W3007814586","https://openalex.org/W3027945570","https://openalex.org/W3087106796","https://openalex.org/W3088285659","https://openalex.org/W3104974184","https://openalex.org/W3130364397","https://openalex.org/W3134395356","https://openalex.org/W3153405385","https://openalex.org/W3156086562","https://openalex.org/W3189004762","https://openalex.org/W6652119814","https://openalex.org/W6666404647","https://openalex.org/W6758925559","https://openalex.org/W6763213322"],"related_works":["https://openalex.org/W1973746459","https://openalex.org/W2095626363","https://openalex.org/W2169565408","https://openalex.org/W1603091392","https://openalex.org/W2121506664","https://openalex.org/W2127229869","https://openalex.org/W3123056048","https://openalex.org/W2150638158","https://openalex.org/W2363184354","https://openalex.org/W2293897539"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}