{"id":"https://openalex.org/W3214205643","doi":"https://doi.org/10.1093/bioinformatics/btab774","title":"Modeling dependency structures in 450k DNA methylation data","display_name":"Modeling dependency structures in 450k DNA methylation data","publication_year":2021,"publication_date":"2021-11-09","ids":{"openalex":"https://openalex.org/W3214205643","doi":"https://doi.org/10.1093/bioinformatics/btab774","mag":"3214205643","pmid":"https://pubmed.ncbi.nlm.nih.gov/34788815"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab774","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab774","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/bioinformatics/btab774","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029480700","display_name":"Haakon E. Nustad","orcid":"https://orcid.org/0000-0002-8659-5716"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I1333353642","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19","country_code":"NO","type":"funder","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Haakon E Nustad","raw_affiliation_strings":["Centre for Fertility and Health, Norwegian Institute of Public Health , 0213 Oslo, Norway","Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital , 0450 Oslo, Norway","Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo , 0371 Oslo, Norway","Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , 0372 Oslo, Norway","Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0372 Oslo, Norway,","Centre for Fertility and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway,","Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital, 0450 Oslo, Norway,","Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo, 0371 Oslo, Norway,"],"affiliations":[{"raw_affiliation_string":"Centre for Fertility and Health, Norwegian Institute of Public Health , 0213 Oslo, Norway","institution_ids":["https://openalex.org/I1333353642"]},{"raw_affiliation_string":"Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital , 0450 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo , 0371 Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo , 0372 Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0372 Oslo, Norway,","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Centre for Fertility and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway,","institution_ids":["https://openalex.org/I1333353642"]},{"raw_affiliation_string":"Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital, 0450 Oslo, Norway,","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo, 0371 Oslo, Norway,","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050449580","display_name":"Ingelin Steinsland","orcid":"https://orcid.org/0000-0002-6344-0754"},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4210124601","display_name":"Department of Mathematical Sciences","ror":"https://ror.org/02xkdev90","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210124601"]}],"countries":["NO","RU"],"is_corresponding":false,"raw_author_name":"Ingelin Steinsland","raw_affiliation_strings":["Department of Mathematical Sciences, Norwegian University of Science and Technology , 7034 Trondheim, Norway","Department of Mathematical Sciences, Norwegian University of Science and Technology, 7034 Trondheim, Norway,"],"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Norwegian University of Science and Technology , 7034 Trondheim, Norway","institution_ids":["https://openalex.org/I204778367","https://openalex.org/I4210124601"]},{"raw_affiliation_string":"Department of Mathematical Sciences, Norwegian University of Science and Technology, 7034 Trondheim, Norway,","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043098809","display_name":"Miina Ollikainen","orcid":"https://orcid.org/0000-0003-3661-7400"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Miina Ollikainen","raw_affiliation_strings":["Helsinki Institute of Life Science, University of Helsinki , FI-00014 Helsinki, Finland","Institute for Molecular Medicine Finland FIMM, , FI-00014 Helsinki, Finland","Institute for Molecular Medicine Finland FIMM, Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland,"],"affiliations":[{"raw_affiliation_string":"Helsinki Institute of Life Science, University of Helsinki , FI-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland FIMM, , FI-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland FIMM, Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051735897","display_name":"Emma Cazaly","orcid":"https://orcid.org/0000-0001-6041-6639"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Emma Cazaly","raw_affiliation_strings":["Helsinki Institute of Life Science, University of Helsinki , FI-00014 Helsinki, Finland","Institute for Molecular Medicine Finland FIMM, , FI-00014 Helsinki, Finland","Institute for Molecular Medicine Finland FIMM, Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland,"],"affiliations":[{"raw_affiliation_string":"Helsinki Institute of Life Science, University of Helsinki , FI-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland FIMM, , FI-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland FIMM, Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002275174","display_name":"Jaakko Kaprio","orcid":"https://orcid.org/0000-0002-3716-2455"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jaakko Kaprio","raw_affiliation_strings":["Helsinki Institute of Life Science, University of Helsinki , FI-00014 Helsinki, Finland","Institute for Molecular Medicine Finland FIMM, , FI-00014 Helsinki, Finland","Institute for Molecular Medicine Finland FIMM, Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland,"],"affiliations":[{"raw_affiliation_string":"Helsinki Institute of Life Science, University of Helsinki , FI-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland FIMM, , FI-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland FIMM, Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland,","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020908928","display_name":"Yuval Benjamini","orcid":"https://orcid.org/0000-0001-8756-8309"},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yuval Benjamini","raw_affiliation_strings":["Department of Statistics and Data Science, The Hebrew University , Mount Scopus, Jerusalem 9190501, Israel","Department of Statistics and Data Science, The Hebrew University, Mount Scopus, Jerusalem 9190501, Israel,"],"affiliations":[{"raw_affiliation_string":"Department of Statistics and Data Science, The Hebrew University , Mount Scopus, Jerusalem 9190501, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Statistics and Data Science, The Hebrew University, Mount Scopus, Jerusalem 9190501, Israel,","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090146676","display_name":"Kristina Gervin","orcid":"https://orcid.org/0000-0002-9851-1890"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kristina Gervin","raw_affiliation_strings":["Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo , 0371 Oslo, Norway","Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital , 0450 Oslo, Norway","Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo , 0363 Oslo, Norway","Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, 0450 Oslo, Norway and","Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo, 0371 Oslo, Norway,"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo , 0371 Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital , 0450 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo , 0363 Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, 0450 Oslo, Norway and","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Department of Pharmacy, PharmaTox Strategic Research Initiative, University of Oslo, 0371 Oslo, Norway,","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027866836","display_name":"Robert Lyle","orcid":"https://orcid.org/0000-0001-6317-732X"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I1333353642","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19","country_code":"NO","type":"funder","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Robert Lyle","raw_affiliation_strings":["Centre for Fertility and Health, Norwegian Institute of Public Health , 0213 Oslo, Norway","Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital , 0450 Oslo, Norway","Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital, 0450 Oslo, Norway,","Centre for Fertility and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway,"],"affiliations":[{"raw_affiliation_string":"Centre for Fertility and Health, Norwegian Institute of Public Health , 0213 Oslo, Norway","institution_ids":["https://openalex.org/I1333353642"]},{"raw_affiliation_string":"Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital , 0450 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Department of Medical Genetics and Norwegian Sequencing Centre, Oslo University Hospital, 0450 Oslo, Norway,","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Centre for Fertility and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway,","institution_ids":["https://openalex.org/I1333353642"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5029480700"],"corresponding_institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I1333353642","https://openalex.org/I184942183"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.732,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.69813507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"38","issue":"4","first_page":"885","last_page":"891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.964900016784668,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dependency","display_name":"Dependency (UML)","score":0.7672131061553955},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6538587808609009},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.640503466129303},{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.6392620205879211},{"id":"https://openalex.org/keywords/zygosity","display_name":"Zygosity","score":0.49341192841529846},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.472674697637558},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.47012150287628174},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4104793071746826},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35204756259918213},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.31364965438842773},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1540822684764862}],"concepts":[{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.7672131061553955},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6538587808609009},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.640503466129303},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.6392620205879211},{"id":"https://openalex.org/C197845989","wikidata":"https://www.wikidata.org/wiki/Q13048280","display_name":"Zygosity","level":2,"score":0.49341192841529846},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.472674697637558},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.47012150287628174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4104793071746826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35204756259918213},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31364965438842773},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1540822684764862},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062206","descriptor_name":"Spatial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062206","descriptor_name":"Spatial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062206","descriptor_name":"Spatial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062206","descriptor_name":"Spatial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062206","descriptor_name":"Spatial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062206","descriptor_name":"Spatial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/bioinformatics/btab774","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab774","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34788815","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34788815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8796368","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8796368","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:fhi.brage.unit.no:11250/3046783","is_oa":true,"landing_page_url":"https://hdl.handle.net/11250/3046783","pdf_url":null,"source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"885-891","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:helda.helsinki.fi:10138/350920","is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/350920","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ntnuopen.ntnu.no:11250/3048146","is_oa":true,"landing_page_url":"https://hdl.handle.net/11250/3048146","pdf_url":null,"source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"885-891","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:www.duo.uio.no:10852/99487","is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/99487","pdf_url":null,"source":{"id":"https://openalex.org/S4306401717","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"1367-4803","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btab774","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab774","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G149161362","display_name":null,"funder_award_id":"30733","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G17482901","display_name":null,"funder_award_id":"241117","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G2000463857","display_name":null,"funder_award_id":"308248, 312073","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G264785854","display_name":null,"funder_award_id":"250362","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G314555889","display_name":null,"funder_award_id":"R01GM083084","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3277496981","display_name":null,"funder_award_id":"GM083084","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3748656914","display_name":null,"funder_award_id":"Norway","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G4148012336","display_name":null,"funder_award_id":"251316","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4344713917","display_name":null,"funder_award_id":"307339","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G5429816300","display_name":null,"funder_award_id":"312073","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G8568119909","display_name":null,"funder_award_id":"308248","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W13930856","https://openalex.org/W588132920","https://openalex.org/W1465453806","https://openalex.org/W1837874438","https://openalex.org/W1987180785","https://openalex.org/W1989568035","https://openalex.org/W1989663044","https://openalex.org/W1995008831","https://openalex.org/W2006435194","https://openalex.org/W2046241907","https://openalex.org/W2052314258","https://openalex.org/W2056040742","https://openalex.org/W2057765075","https://openalex.org/W2058306877","https://openalex.org/W2067724039","https://openalex.org/W2099343472","https://openalex.org/W2112500414","https://openalex.org/W2113588666","https://openalex.org/W2115936826","https://openalex.org/W2123174009","https://openalex.org/W2127431419","https://openalex.org/W2130761473","https://openalex.org/W2139594740","https://openalex.org/W2144898279","https://openalex.org/W2164516088","https://openalex.org/W2168447003","https://openalex.org/W2295283034","https://openalex.org/W2496675188","https://openalex.org/W2537310520","https://openalex.org/W2593934358","https://openalex.org/W2944524138","https://openalex.org/W2970011713","https://openalex.org/W2982011104","https://openalex.org/W2994296556","https://openalex.org/W3167480409","https://openalex.org/W6664404399","https://openalex.org/W6728994268"],"related_works":["https://openalex.org/W2145817007","https://openalex.org/W2135903676","https://openalex.org/W2416269993","https://openalex.org/W4239943914","https://openalex.org/W3113746618","https://openalex.org/W4226051228","https://openalex.org/W2214376880","https://openalex.org/W3212149434","https://openalex.org/W2073893804","https://openalex.org/W2291484187"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-11T08:14:18.477133","created_date":"2025-10-10T00:00:00"}