{"id":"https://openalex.org/W3177878434","doi":"https://doi.org/10.1093/bioinformatics/btab502","title":"Differential network analysis by simultaneously considering changes in gene interactions and gene expression","display_name":"Differential network analysis by simultaneously considering changes in gene interactions and gene expression","publication_year":2021,"publication_date":"2021-07-05","ids":{"openalex":"https://openalex.org/W3177878434","doi":"https://doi.org/10.1093/bioinformatics/btab502","mag":"3177878434","pmid":"https://pubmed.ncbi.nlm.nih.gov/34245246"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab502","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab502","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059809364","display_name":"Jia-Juan Tu","orcid":"https://orcid.org/0000-0002-7912-6030"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Juan Tu","raw_affiliation_strings":["School of Mathematics and Statistics and Hubei Key Laboratory of Mathematical Sciences, Central China Normal University , Wuhan 430079, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics and Hubei Key Laboratory of Mathematical Sciences, Central China Normal University , Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030129372","display_name":"Le Ou-Yang","orcid":"https://orcid.org/0000-0003-4007-4568"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Ou-Yang","raw_affiliation_strings":["College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060, China"],"affiliations":[{"raw_affiliation_string":"College of Electronics and Information Engineering, Shenzhen University , Shenzhen 518060, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046009262","display_name":"Yuan Zhu","orcid":"https://orcid.org/0000-0003-1372-9135"},"institutions":[{"id":"https://openalex.org/I3124059619","display_name":"China University of Geosciences","ror":"https://ror.org/04gcegc37","country_code":"CN","type":"education","lineage":["https://openalex.org/I3124059619"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Zhu","raw_affiliation_strings":["Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems, China University of Geosciences , Wuhan 430074, China","School of Automation, China University of Geosciences , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems, China University of Geosciences , Wuhan 430074, China","institution_ids":["https://openalex.org/I3124059619"]},{"raw_affiliation_string":"School of Automation, China University of Geosciences , Wuhan 430074, China","institution_ids":["https://openalex.org/I3124059619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644375","display_name":"Hong Yan","orcid":"https://orcid.org/0000-0001-9661-3095"},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hong Yan","raw_affiliation_strings":["Department of Electrical Engineering, City University of Hong Kong , Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, City University of Hong Kong , Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102025009","display_name":"Hong Qin","orcid":"https://orcid.org/0000-0001-7463-2914"},"institutions":[{"id":"https://openalex.org/I158934434","display_name":"Zhongnan University of Economics and Law","ror":"https://ror.org/04yqxxq63","country_code":"CN","type":"education","lineage":["https://openalex.org/I158934434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Qin","raw_affiliation_strings":["Department of Statistics, Zhongnan University of Economics and Law , Wuhan 430073, China"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Zhongnan University of Economics and Law , Wuhan 430073, China","institution_ids":["https://openalex.org/I158934434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100447043","display_name":"Xiao-Fei Zhang","orcid":"https://orcid.org/0000-0002-5052-9725"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Fei Zhang","raw_affiliation_strings":["School of Mathematics and Statistics and Hubei Key Laboratory of Mathematical Sciences, Central China Normal University , Wuhan 430079, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics and Hubei Key Laboratory of Mathematical Sciences, Central China Normal University , Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100447043"],"corresponding_institution_ids":["https://openalex.org/I40963666"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.448,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.81970832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"37","issue":"23","first_page":"4414","last_page":"4423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.6204380989074707},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5783365368843079},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5539382100105286},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5197207927703857},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.49184131622314453},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4567176103591919},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4540886878967285},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.42105403542518616},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.41014426946640015},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3800048232078552},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20670539140701294}],"concepts":[{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.6204380989074707},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5783365368843079},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5539382100105286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5197207927703857},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.49184131622314453},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4567176103591919},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4540886878967285},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42105403542518616},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.41014426946640015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3800048232078552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20670539140701294},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btab502","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab502","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34245246","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34245246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.49000000953674316,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2587881520","display_name":null,"funder_award_id":"11871237","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4256946538","display_name":null,"funder_award_id":"JCYJ20170817095210760","funder_id":"https://openalex.org/F4320329791","funder_display_name":"Shenzhen Fundamental Research Program"},{"id":"https://openalex.org/G4434048650","display_name":null,"funder_award_id":"61602309","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G549144630","display_name":null,"funder_award_id":"2019A1515011384","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G8657404496","display_name":null,"funder_award_id":"11871026","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329791","display_name":"Shenzhen Fundamental Research Program","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W158191276","https://openalex.org/W1520332974","https://openalex.org/W1965660529","https://openalex.org/W1966738468","https://openalex.org/W1967186439","https://openalex.org/W1978606283","https://openalex.org/W1986682393","https://openalex.org/W1992425170","https://openalex.org/W1994041743","https://openalex.org/W1995428794","https://openalex.org/W2028553898","https://openalex.org/W2035114699","https://openalex.org/W2035618305","https://openalex.org/W2037559873","https://openalex.org/W2047031939","https://openalex.org/W2062533676","https://openalex.org/W2064026123","https://openalex.org/W2081746825","https://openalex.org/W2092280338","https://openalex.org/W2096283457","https://openalex.org/W2101432452","https://openalex.org/W2107667998","https://openalex.org/W2108156593","https://openalex.org/W2111166021","https://openalex.org/W2114104545","https://openalex.org/W2131888987","https://openalex.org/W2138576397","https://openalex.org/W2139227366","https://openalex.org/W2147566730","https://openalex.org/W2154947819","https://openalex.org/W2163487866","https://openalex.org/W2165009258","https://openalex.org/W2347110697","https://openalex.org/W2465098683","https://openalex.org/W2507283296","https://openalex.org/W2524076512","https://openalex.org/W2607356028","https://openalex.org/W2619100367","https://openalex.org/W2772433889","https://openalex.org/W2777527666","https://openalex.org/W2800846444","https://openalex.org/W2913868028","https://openalex.org/W2945823867","https://openalex.org/W2950225911","https://openalex.org/W2963269830","https://openalex.org/W3008081001","https://openalex.org/W3024582588","https://openalex.org/W3034771873","https://openalex.org/W3036915285","https://openalex.org/W3098834468","https://openalex.org/W3102650760","https://openalex.org/W3103173371","https://openalex.org/W3108614647","https://openalex.org/W4294216483","https://openalex.org/W4301588852","https://openalex.org/W6684098844","https://openalex.org/W6684415991","https://openalex.org/W6745587002","https://openalex.org/W6779993003","https://openalex.org/W6785673176"],"related_works":["https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W249159571","https://openalex.org/W2791736663","https://openalex.org/W2806770614","https://openalex.org/W2129949791","https://openalex.org/W2131550814","https://openalex.org/W1710460698","https://openalex.org/W3199739261"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3}],"updated_date":"2026-02-27T16:54:17.756197","created_date":"2025-10-10T00:00:00"}