{"id":"https://openalex.org/W3166925323","doi":"https://doi.org/10.1093/bioinformatics/btab463","title":"EPSOL: sequence-based protein solubility prediction using multidimensional embedding","display_name":"EPSOL: sequence-based protein solubility prediction using multidimensional embedding","publication_year":2021,"publication_date":"2021-06-17","ids":{"openalex":"https://openalex.org/W3166925323","doi":"https://doi.org/10.1093/bioinformatics/btab463","mag":"3166925323","pmid":"https://pubmed.ncbi.nlm.nih.gov/34145885"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btab463","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab463","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054320955","display_name":"Xiang Wu","orcid":"https://orcid.org/0000-0002-6305-1206"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Wu","raw_affiliation_strings":["School of Computer Science and Technology, Xidian University , Xi\u2019an, Shaanxi 710071, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xidian University , Xi\u2019an, Shaanxi 710071, China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054977113","display_name":"Liang Yu","orcid":"https://orcid.org/0000-0002-8351-3332"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Yu","raw_affiliation_strings":["School of Computer Science and Technology, Xidian University , Xi\u2019an, Shaanxi 710071, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Xidian University , Xi\u2019an, Shaanxi 710071, China","institution_ids":["https://openalex.org/I149594827"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054977113"],"corresponding_institution_ids":["https://openalex.org/I149594827"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.5708,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.94254035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"37","issue":"23","first_page":"4314","last_page":"4320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solubility","display_name":"Solubility","score":0.8559682965278625},{"id":"https://openalex.org/keywords/yield","display_name":"Yield (engineering)","score":0.5958563685417175},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5313164591789246},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5025041103363037},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4985823631286621},{"id":"https://openalex.org/keywords/recombinant-dna","display_name":"Recombinant DNA","score":0.4665481746196747},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.42230337858200073},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4195585548877716},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3558238744735718},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3331323564052582},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.327384352684021},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.28532493114471436},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2494301199913025},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2249334156513214},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.1763351857662201},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.11244580149650574}],"concepts":[{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.8559682965278625},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5958563685417175},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5313164591789246},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5025041103363037},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4985823631286621},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4665481746196747},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.42230337858200073},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4195585548877716},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3558238744735718},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3331323564052582},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.327384352684021},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.28532493114471436},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2494301199913025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2249334156513214},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1763351857662201},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.11244580149650574},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btab463","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btab463","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34145885","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34145885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1903355035","display_name":null,"funder_award_id":"61672406","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G375568310","display_name":null,"funder_award_id":"62072353","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6640186486","display_name":null,"funder_award_id":"61532014","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G875591309","display_name":null,"funder_award_id":"2018YFC0910403","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1496317909","https://openalex.org/W1538131130","https://openalex.org/W1588724272","https://openalex.org/W1678356000","https://openalex.org/W1847611580","https://openalex.org/W1972978214","https://openalex.org/W1993282040","https://openalex.org/W2067602907","https://openalex.org/W2075644998","https://openalex.org/W2089468765","https://openalex.org/W2095705004","https://openalex.org/W2096495474","https://openalex.org/W2109449939","https://openalex.org/W2119246926","https://openalex.org/W2119821739","https://openalex.org/W2131474431","https://openalex.org/W2133458779","https://openalex.org/W2142920810","https://openalex.org/W2156125289","https://openalex.org/W2170747616","https://openalex.org/W2255304239","https://openalex.org/W2462790866","https://openalex.org/W2766578745","https://openalex.org/W2794004073","https://openalex.org/W2805110914","https://openalex.org/W2891888787","https://openalex.org/W2900694973","https://openalex.org/W2947498044","https://openalex.org/W2965878291","https://openalex.org/W2984274952","https://openalex.org/W2998704965","https://openalex.org/W2999819730","https://openalex.org/W3004263072","https://openalex.org/W3005031658","https://openalex.org/W3019362006","https://openalex.org/W3046868072","https://openalex.org/W3047705148","https://openalex.org/W3094567318","https://openalex.org/W3112172360","https://openalex.org/W3119632172","https://openalex.org/W3120622940","https://openalex.org/W3122775348","https://openalex.org/W3176301303","https://openalex.org/W4239510810","https://openalex.org/W4247571305","https://openalex.org/W4285719527","https://openalex.org/W4319425375","https://openalex.org/W6632100814","https://openalex.org/W6671376181","https://openalex.org/W6674330103","https://openalex.org/W6680532216","https://openalex.org/W6773746074","https://openalex.org/W6785345244","https://openalex.org/W6787095773","https://openalex.org/W6787933358"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2949184651","https://openalex.org/W2952649848","https://openalex.org/W2401463829","https://openalex.org/W2950847194","https://openalex.org/W1986991025","https://openalex.org/W2950230984","https://openalex.org/W2403975342","https://openalex.org/W1992065723"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":9}],"updated_date":"2026-03-25T14:56:36.534964","created_date":"2025-10-10T00:00:00"}