{"id":"https://openalex.org/W3045360419","doi":"https://doi.org/10.1093/bioinformatics/btaa658","title":"Differential Gene Set Enrichment Analysis: a statistical approach to quantify the relative enrichment of two gene sets","display_name":"Differential Gene Set Enrichment Analysis: a statistical approach to quantify the relative enrichment of two gene sets","publication_year":2020,"publication_date":"2020-07-16","ids":{"openalex":"https://openalex.org/W3045360419","doi":"https://doi.org/10.1093/bioinformatics/btaa658","mag":"3045360419","pmid":"https://pubmed.ncbi.nlm.nih.gov/32692836"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa658","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa658","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8453775","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015621451","display_name":"James H. Joly","orcid":"https://orcid.org/0000-0003-3780-9412"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H Joly","raw_affiliation_strings":["Mork Family Department of Chemical Engineering and Materials Science, University of Southern California , Los Angeles, CA 90089, USA"],"affiliations":[{"raw_affiliation_string":"Mork Family Department of Chemical Engineering and Materials Science, University of Southern California , Los Angeles, CA 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008667539","display_name":"William E. Lowry","orcid":"https://orcid.org/0000-0003-2932-2276"},"institutions":[{"id":"https://openalex.org/I4210150380","display_name":"Broad Center","ror":"https://ror.org/04tbrah05","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150380"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E Lowry","raw_affiliation_strings":["Broad Center for Regenerative Medicine , Los Angeles, Los Angeles, CA 90095, USA","Department of Molecular, Cell, and Developmental Biology , Los Angeles, Los Angeles, CA 90095, USA","Division of Dermatology, David Geffen School of Medicine , Los Angeles, Los Angeles, CA 90095, USA","Jonsson Comprehensive Cancer Center, University of California , Los Angeles, Los Angeles, CA 90095, USA","Molecular Biology Institute , Los Angeles, Los Angeles, CA 90095, USA"],"affiliations":[{"raw_affiliation_string":"Broad Center for Regenerative Medicine , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I4210150380"]},{"raw_affiliation_string":"Department of Molecular, Cell, and Developmental Biology , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":[]},{"raw_affiliation_string":"Division of Dermatology, David Geffen School of Medicine , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute , Los Angeles, Los Angeles, CA 90095, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102835289","display_name":"Nicholas A. Graham","orcid":"https://orcid.org/0000-0002-6811-1941"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas A Graham","raw_affiliation_strings":["Mork Family Department of Chemical Engineering and Materials Science, University of Southern California , Los Angeles, CA 90089, USA","Norris Comprehensive Cancer Center, University of Southern California , Los Angeles, CA 90089, USA"],"affiliations":[{"raw_affiliation_string":"Mork Family Department of Chemical Engineering and Materials Science, University of Southern California , Los Angeles, CA 90089, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Norris Comprehensive Cancer Center, University of Southern California , Los Angeles, CA 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102835289"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.7399,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.84985661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"36","issue":"21","first_page":"5247","last_page":"5254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6167297959327698},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.576759397983551},{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.5708079934120178},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5315373539924622},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5242151021957397},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.45347195863723755},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.44266027212142944},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.40046426653862},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3340767025947571},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2453787624835968}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6167297959327698},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.576759397983551},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5708079934120178},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5315373539924622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5242151021957397},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.45347195863723755},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.44266027212142944},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.40046426653862},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3340767025947571},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2453787624835968},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btaa658","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa658","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32692836","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32692836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:7346909","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8453775","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8453775","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8453775","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8453775","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8453775","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4137590650","display_name":null,"funder_award_id":"1R01AR070245-01A1","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334234","display_name":"Viterbi School of Engineering, University of Southern California","ror":null},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1967789049","https://openalex.org/W1989095484","https://openalex.org/W2022451432","https://openalex.org/W2038003361","https://openalex.org/W2099618765","https://openalex.org/W2108195113","https://openalex.org/W2113619479","https://openalex.org/W2118460019","https://openalex.org/W2130410032","https://openalex.org/W2131848047","https://openalex.org/W2134736660","https://openalex.org/W2159707944","https://openalex.org/W2315519665","https://openalex.org/W2588804631","https://openalex.org/W2599353531","https://openalex.org/W2763871199","https://openalex.org/W2784146930","https://openalex.org/W2795010312","https://openalex.org/W2884367460","https://openalex.org/W2944723276","https://openalex.org/W2950668056","https://openalex.org/W2962821542","https://openalex.org/W2979416641","https://openalex.org/W4210433744","https://openalex.org/W6768904998"],"related_works":["https://openalex.org/W1976510917","https://openalex.org/W2073305407","https://openalex.org/W2052655934","https://openalex.org/W104645380","https://openalex.org/W2027213253","https://openalex.org/W2017047508","https://openalex.org/W2165201120","https://openalex.org/W2023641020","https://openalex.org/W2188530857","https://openalex.org/W2133040682"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4}],"updated_date":"2025-11-23T05:10:03.516525","created_date":"2025-10-10T00:00:00"}