{"id":"https://openalex.org/W3040634151","doi":"https://doi.org/10.1093/bioinformatics/btaa610","title":"Rapid epistatic mixed-model association studies by controlling multiple polygenic effects","display_name":"Rapid epistatic mixed-model association studies by controlling multiple polygenic effects","publication_year":2020,"publication_date":"2020-06-24","ids":{"openalex":"https://openalex.org/W3040634151","doi":"https://doi.org/10.1093/bioinformatics/btaa610","mag":"3040634151","pmid":"https://pubmed.ncbi.nlm.nih.gov/32614415"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa610","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa610","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100709844","display_name":"Dan Wang","orcid":"https://orcid.org/0000-0001-9079-2360"},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Wang","raw_affiliation_strings":["Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"],"affiliations":[{"raw_affiliation_string":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043687065","display_name":"Hui Tang","orcid":"https://orcid.org/0000-0002-4232-4607"},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Tang","raw_affiliation_strings":["Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"],"affiliations":[{"raw_affiliation_string":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335775","display_name":"Jianfeng Liu","orcid":"https://orcid.org/0000-0002-5766-7864"},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Feng Liu","raw_affiliation_strings":["Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, China Agricultural University , Beijing 100193, China"],"affiliations":[{"raw_affiliation_string":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, China Agricultural University , Beijing 100193, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004706867","display_name":"Shizhong Xu","orcid":"https://orcid.org/0000-0001-6789-6655"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shizhong Xu","raw_affiliation_strings":["Department of Botany and Plant Science, University of California , Riverside, CA 92521, USA"],"affiliations":[{"raw_affiliation_string":"Department of Botany and Plant Science, University of California , Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418221","display_name":"Qin Zhang","orcid":"https://orcid.org/0000-0002-4597-7697"},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Zhang","raw_affiliation_strings":["Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"],"affiliations":[{"raw_affiliation_string":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China","institution_ids":["https://openalex.org/I74485261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101607466","display_name":"Chao Ning","orcid":"https://orcid.org/0000-0001-8247-1700"},"institutions":[{"id":"https://openalex.org/I74485261","display_name":"Shandong Agricultural University","ror":"https://ror.org/02ke8fw32","country_code":"CN","type":"education","lineage":["https://openalex.org/I74485261"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chao Ning","raw_affiliation_strings":["Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"],"affiliations":[{"raw_affiliation_string":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China","institution_ids":["https://openalex.org/I74485261"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100418221","https://openalex.org/A5101607466"],"corresponding_institution_ids":["https://openalex.org/I74485261"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":7.206,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.9750668,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"36","issue":"19","first_page":"4833","last_page":"4837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.8128091096878052},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.807744562625885},{"id":"https://openalex.org/keywords/xeon","display_name":"Xeon","score":0.590884804725647},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5820865035057068},{"id":"https://openalex.org/keywords/additive-model","display_name":"Additive model","score":0.5558407306671143},{"id":"https://openalex.org/keywords/dominance","display_name":"Dominance (genetics)","score":0.4597703218460083},{"id":"https://openalex.org/keywords/linear-model","display_name":"Linear model","score":0.4418700933456421},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.43559882044792175},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.42701074481010437},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3246745765209198},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26663321256637573},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24786221981048584},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21649643778800964},{"id":"https://openalex.org/keywords/parallel-computing","display_name":"Parallel computing","score":0.19617754220962524},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16145575046539307},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14135706424713135}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.8128091096878052},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.807744562625885},{"id":"https://openalex.org/C145108525","wikidata":"https://www.wikidata.org/wiki/Q656154","display_name":"Xeon","level":2,"score":0.590884804725647},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5820865035057068},{"id":"https://openalex.org/C203223496","wikidata":"https://www.wikidata.org/wiki/Q4681344","display_name":"Additive model","level":2,"score":0.5558407306671143},{"id":"https://openalex.org/C151913843","wikidata":"https://www.wikidata.org/wiki/Q3454555","display_name":"Dominance (genetics)","level":3,"score":0.4597703218460083},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.4418700933456421},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43559882044792175},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.42701074481010437},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3246745765209198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26663321256637573},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24786221981048584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21649643778800964},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.19617754220962524},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16145575046539307},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14135706424713135},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btaa610","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa610","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32614415","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32614415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5929091769","display_name":null,"funder_award_id":"31872344","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1822695366","https://openalex.org/W1968530769","https://openalex.org/W2019961888","https://openalex.org/W2052363244","https://openalex.org/W2067328319","https://openalex.org/W2094189284","https://openalex.org/W2118215201","https://openalex.org/W2127684760","https://openalex.org/W2134036574","https://openalex.org/W2134783591","https://openalex.org/W2158547433","https://openalex.org/W2161633633","https://openalex.org/W2169088065","https://openalex.org/W2170554520","https://openalex.org/W2265889397","https://openalex.org/W2303043072","https://openalex.org/W2783657549","https://openalex.org/W2949625879","https://openalex.org/W2950277954","https://openalex.org/W6684520314"],"related_works":["https://openalex.org/W2050124665","https://openalex.org/W4393235329","https://openalex.org/W2573031217","https://openalex.org/W655674951","https://openalex.org/W4287066720","https://openalex.org/W4391124857","https://openalex.org/W4301443849","https://openalex.org/W3186046688","https://openalex.org/W3127711009","https://openalex.org/W2170943797"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":3}],"updated_date":"2026-04-12T07:58:50.170612","created_date":"2025-10-10T00:00:00"}
