{"id":"https://openalex.org/W3026236133","doi":"https://doi.org/10.1093/bioinformatics/btaa532","title":"scTPA: a web tool for single-cell transcriptome analysis of pathway activation signatures","display_name":"scTPA: a web tool for single-cell transcriptome analysis of pathway activation signatures","publication_year":2020,"publication_date":"2020-05-15","ids":{"openalex":"https://openalex.org/W3026236133","doi":"https://doi.org/10.1093/bioinformatics/btaa532","mag":"3026236133","pmid":"https://pubmed.ncbi.nlm.nih.gov/32437538"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa532","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa532","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100456195","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-1011-6184"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610339","display_name":"Yaru Zhang","orcid":"https://orcid.org/0000-0002-6167-7248"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaru Zhang","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029914279","display_name":"Jun Hu","orcid":"https://orcid.org/0000-0001-9202-7515"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Hu","raw_affiliation_strings":["College of Information Engineering, Zhejiang University of Technology , Hangzhou 310023, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Zhejiang University of Technology , Hangzhou 310023, Zhejiang, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329261","display_name":"Ji Zhang","orcid":"https://orcid.org/0000-0002-2238-5824"},"institutions":[{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji Zhang","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018247966","display_name":"Fangjie Guo","orcid":"https://orcid.org/0000-0002-7688-7475"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangjie Guo","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024023342","display_name":"Meng Zhou","orcid":"https://orcid.org/0000-0001-9987-9024"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Zhou","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049735973","display_name":"Guijun Zhang","orcid":"https://orcid.org/0000-0002-7815-5884"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guijun Zhang","raw_affiliation_strings":["College of Information Engineering, Zhejiang University of Technology , Hangzhou 310023, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Zhejiang University of Technology , Hangzhou 310023, Zhejiang, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059967860","display_name":"Fulong Yu","orcid":"https://orcid.org/0000-0002-6100-8300"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fulong Yu","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083159278","display_name":"Jianzhong Su","orcid":"https://orcid.org/0000-0002-1172-7411"},"institutions":[{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhong Su","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University , Wenzhou 325011, Zhejiang, China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100456195"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210086973"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.7399,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.84820542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"36","issue":"14","first_page":"4217","last_page":"4219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6157302260398865},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5703378915786743},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5670092105865479},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.5329115390777588},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4796900451183319},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3553658127784729},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1516900360584259},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14664989709854126},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1281191110610962}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6157302260398865},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5703378915786743},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5670092105865479},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.5329115390777588},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4796900451183319},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3553658127784729},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1516900360584259},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14664989709854126},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1281191110610962},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btaa532","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa532","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32437538","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32437538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2369485005","display_name":null,"funder_award_id":"61903277","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2708836668","display_name":null,"funder_award_id":"61773346","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4337635401","display_name":null,"funder_award_id":"61873193","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4778637638","display_name":null,"funder_award_id":"61871294","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G571753479","display_name":null,"funder_award_id":"61902352","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1988391018","https://openalex.org/W2051658465","https://openalex.org/W2069089843","https://openalex.org/W2120261416","https://openalex.org/W2288153033","https://openalex.org/W2332292689","https://openalex.org/W2540833380","https://openalex.org/W2610509384","https://openalex.org/W2794480084","https://openalex.org/W2886347923","https://openalex.org/W2899224111","https://openalex.org/W2969593942","https://openalex.org/W2976681669","https://openalex.org/W2982274943","https://openalex.org/W2991414673","https://openalex.org/W3005039546","https://openalex.org/W3007199577","https://openalex.org/W3104221309"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W4206493863","https://openalex.org/W2151866902","https://openalex.org/W2347179827","https://openalex.org/W2157193718","https://openalex.org/W2046406569"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-23T05:10:03.516525","created_date":"2025-10-10T00:00:00"}