{"id":"https://openalex.org/W3033740922","doi":"https://doi.org/10.1093/bioinformatics/btaa294","title":"<i>HiG</i>was: how to compute longitudinal GWAS data in population designs","display_name":"<i>HiG</i>was: how to compute longitudinal GWAS data in population designs","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3033740922","doi":"https://doi.org/10.1093/bioinformatics/btaa294","mag":"3033740922","pmid":"https://pubmed.ncbi.nlm.nih.gov/32502244"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btaa294","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa294","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/14/4222/34306817/btaa294.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/36/14/4222/34306817/btaa294.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103179901","display_name":"Wang Zhong","orcid":"https://orcid.org/0000-0002-1204-5471"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhong Wang","raw_affiliation_strings":["Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","School of Software Technology , Dalian University of Technology, Dalian 116023, China","The College of Arts & Sciences , Cornell University, Ithaca, NY 14850, USA"],"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"School of Software Technology , Dalian University of Technology, Dalian 116023, China","institution_ids":["https://openalex.org/I27357992"]},{"raw_affiliation_string":"The College of Arts & Sciences , Cornell University, Ithaca, NY 14850, USA","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016486120","display_name":"Nating Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nating Wang","raw_affiliation_strings":["Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"],"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064128334","display_name":"Zilu Wang","orcid":"https://orcid.org/0000-0002-5957-8064"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zilu Wang","raw_affiliation_strings":["Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","School of Software Technology , Dalian University of Technology, Dalian 116023, China","The College of Arts & Sciences , Cornell University, Ithaca, NY 14850, USA"],"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"School of Software Technology , Dalian University of Technology, Dalian 116023, China","institution_ids":["https://openalex.org/I27357992"]},{"raw_affiliation_string":"The College of Arts & Sciences , Cornell University, Ithaca, NY 14850, USA","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020151036","display_name":"Libo Jiang","orcid":"https://orcid.org/0000-0003-4703-9220"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Libo Jiang","raw_affiliation_strings":["Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China"],"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013404660","display_name":"Yaqun Wang","orcid":"https://orcid.org/0000-0002-3955-9827"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaqun Wang","raw_affiliation_strings":["Department of Biostatistics , Rutgers University, New Brunswick, NJ 08901, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , Rutgers University, New Brunswick, NJ 08901, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103001404","display_name":"Jiahan Li","orcid":"https://orcid.org/0000-0003-2541-5280"},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiahan Li","raw_affiliation_strings":["Department of Applied and Computational Mathematics and Statistics , University of Notre Dame, Notre Dame, IN 46556, USA"],"affiliations":[{"raw_affiliation_string":"Department of Applied and Computational Mathematics and Statistics , University of Notre Dame, Notre Dame, IN 46556, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031422180","display_name":"Rongling Wu","orcid":"https://orcid.org/0000-0001-8350-7779"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Rongling Wu","raw_affiliation_strings":["Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","Center for Statistical Genetics , Departments of Public Health Sciences and Statistics, The Pennsylvania State University, Hershey, PA 17033, USA"],"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Center for Tree Breeding by Molecular Design , Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Center for Computational Biology , College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Center for Statistical Genetics , Departments of Public Health Sciences and Statistics, The Pennsylvania State University, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5031422180"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I31683504"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.3587,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66513642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"36","issue":"14","first_page":"4222","last_page":"4224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9697999954223633,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9434999823570251,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.6013368368148804},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49976539611816406},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4623471796512604},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18936264514923096},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16547784209251404},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14312297105789185},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.08800247311592102},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.07665523886680603}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6013368368148804},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49976539611816406},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4623471796512604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18936264514923096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16547784209251404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14312297105789185},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08800247311592102},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.07665523886680603},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btaa294","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa294","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/14/4222/34306817/btaa294.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32502244","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32502244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btaa294","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btaa294","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/14/4222/34306817/btaa294.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7445729572","display_name":null,"funder_award_id":"31470675","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033740922.pdf","grobid_xml":"https://content.openalex.org/works/W3033740922.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1889787453","https://openalex.org/W1996952375","https://openalex.org/W1997840761","https://openalex.org/W2014004789","https://openalex.org/W2085766216","https://openalex.org/W2132497650","https://openalex.org/W2147272585","https://openalex.org/W2187181884","https://openalex.org/W2267834167","https://openalex.org/W2433332932","https://openalex.org/W2540182532","https://openalex.org/W2583698053","https://openalex.org/W2585681007","https://openalex.org/W2739407175","https://openalex.org/W2903149572","https://openalex.org/W2950277954","https://openalex.org/W3102013963"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W1539935214","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W4390666975","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W1864400744"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2020-06-12T00:00:00"}