{"id":"https://openalex.org/W2144594011","doi":"https://doi.org/10.1093/bib/bbt049","title":"Controlling for confounding variables in MS-omics protocol: why modularity matters","display_name":"Controlling for confounding variables in MS-omics protocol: why modularity matters","publication_year":2013,"publication_date":"2013-07-27","ids":{"openalex":"https://openalex.org/W2144594011","doi":"https://doi.org/10.1093/bib/bbt049","mag":"2144594011","pmid":"https://pubmed.ncbi.nlm.nih.gov/23894105"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbt049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbt049","pdf_url":"https://academic.oup.com/bib/article-pdf/15/5/768/7252644/bbt049.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/15/5/768/7252644/bbt049.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023982706","display_name":"Richard Smith","orcid":"https://orcid.org/0000-0002-2381-2349"},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Smith","raw_affiliation_strings":["Rob Smith is a PhD candidate in computer science at Brigham Young University. His research comprises algorithmic approaches to problems in proteomics and lipidomics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rob Smith is a PhD candidate in computer science at Brigham Young University. His research comprises algorithmic approaches to problems in proteomics and lipidomics","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064318273","display_name":"Dan Ventura","orcid":"https://orcid.org/0000-0002-3111-2238"},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Ventura","raw_affiliation_strings":["Dan Ventura is a Professor in the Department of Computer Science, Brigham Young University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dan Ventura is a Professor in the Department of Computer Science, Brigham Young University","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041650906","display_name":"John T. Prince","orcid":"https://orcid.org/0000-0001-9820-4252"},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. T. Prince","raw_affiliation_strings":["John T. Prince is an Assistant Professor in the Department of Chemistry and Biochemistry, Brigham Young University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John T. Prince is an Assistant Professor in the Department of Chemistry and Biochemistry, Brigham Young University","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I100005738"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.0474,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.771154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"5","first_page":"768","last_page":"770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12073","display_name":"Isotope Analysis in Ecology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.7636323571205139},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.7290177345275879},{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.6387245655059814},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6360270977020264},{"id":"https://openalex.org/keywords/variable","display_name":"Variable (mathematics)","score":0.5188987851142883},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.48696693778038025},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41751497983932495},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.38712453842163086},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3245200514793396},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1633026897907257},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15545609593391418},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13504916429519653},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10927644371986389}],"concepts":[{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.7636323571205139},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.7290177345275879},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.6387245655059814},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6360270977020264},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.5188987851142883},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.48696693778038025},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41751497983932495},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.38712453842163086},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3245200514793396},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1633026897907257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15545609593391418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13504916429519653},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10927644371986389},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbt049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbt049","pdf_url":"https://academic.oup.com/bib/article-pdf/15/5/768/7252644/bbt049.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23894105","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23894105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbt049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbt049","pdf_url":"https://academic.oup.com/bib/article-pdf/15/5/768/7252644/bbt049.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144594011.pdf"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1989299822","https://openalex.org/W2052388444","https://openalex.org/W2108725536","https://openalex.org/W2113153354","https://openalex.org/W2115166033","https://openalex.org/W2276836411","https://openalex.org/W2519438632"],"related_works":["https://openalex.org/W4230687177","https://openalex.org/W1968829728","https://openalex.org/W2349859869","https://openalex.org/W2994176440","https://openalex.org/W2051365847","https://openalex.org/W2367249529","https://openalex.org/W3120118008","https://openalex.org/W2481749367","https://openalex.org/W2510575233","https://openalex.org/W4214765864"],"abstract_inverted_index":{"As":[0,64],"the":[1,38,65,73,86],"field":[2],"of":[3,69,82,88],"bioinformatics":[4,54,93],"research":[5],"continues":[6],"to":[7,16,24,57,76],"grow,":[8],"more":[9,11],"and":[10,20,32,46,61,78],"novel":[12],"techniques":[13,31,55,94],"are":[14],"proposed":[15],"meet":[17],"new":[18],"challenges":[19],"improvements":[21],"upon":[22],"solutions":[23],"long-standing":[25],"problems.":[26],"These":[27],"include":[28],"data":[29],"processing":[30],"wet":[33,50],"lab":[34,51],"protocol":[35,52],"techniques.":[36],"Although":[37],"literature":[39],"is":[40],"consistently":[41],"thorough":[42],"in":[43,92],"experimental":[44],"detail":[45],"variable-controlling":[47],"rigor":[48],"for":[49],"techniques,":[53],"tend":[56],"be":[58],"less":[59,62],"described":[60],"controlled.":[63],"validation":[66],"or":[67],"rejection":[68],"hypotheses":[70],"rests":[71],"on":[72],"experiment's":[74],"ability":[75],"isolate":[77],"measure":[79],"a":[80],"variable":[81],"interest,":[83],"we":[84],"urge":[85],"importance":[87],"reducing":[89],"confounding":[90],"variables":[91],"during":[95],"mass":[96],"spectrometry":[97],"experimentation.":[98]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
