{"id":"https://openalex.org/W2164547064","doi":"https://doi.org/10.1093/bib/bbp071","title":"Developing computational model-based diagnostics to analyse clinical chemistry data","display_name":"Developing computational model-based diagnostics to analyse clinical chemistry data","publication_year":2010,"publication_date":"2010-01-07","ids":{"openalex":"https://openalex.org/W2164547064","doi":"https://doi.org/10.1093/bib/bbp071","mag":"2164547064","pmid":"https://pubmed.ncbi.nlm.nih.gov/20056728"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbp071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp071","pdf_url":"https://academic.oup.com/bib/article-pdf/11/4/403/623970/bbp071.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/11/4/403/623970/bbp071.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041494883","display_name":"Dani\u00ebl B. van Schalkwijk","orcid":null},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D. B. van Schalkwijk","raw_affiliation_strings":["U TNO Quality of Life Research Institute and at Leiden Amsterdam Centre for Drug Research at Leiden University. daan.vanschalkwijk@tno.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U TNO Quality of Life Research Institute and at Leiden Amsterdam Centre for Drug Research at Leiden University. daan.vanschalkwijk@tno.nl","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I4210133171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036906000","display_name":"Kees van Bochove","orcid":"https://orcid.org/0000-0002-8589-0609"},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. van Bochove","raw_affiliation_strings":["Kees van Bochove has done his master\u2019s thesis in bioinformatics at the TNO Quality of Life Research Institute, in collaboration with the TUFTS University in Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kees van Bochove has done his master\u2019s thesis in bioinformatics at the TNO Quality of Life Research Institute, in collaboration with the TUFTS University in Boston","institution_ids":["https://openalex.org/I4210148697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049866928","display_name":"Ben van Ommen","orcid":"https://orcid.org/0000-0002-0124-9428"},"institutions":[{"id":"https://openalex.org/I1320481043","display_name":"European Union","ror":"https://ror.org/019w4f821","country_code":"BE","type":"government","lineage":["https://openalex.org/I1320481043"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"B. van Ommen","raw_affiliation_strings":["Ben van Ommen is a senior research fellow at the TNO Quality of Life Research Institute and Director of the NuGO network of excellence funded by the European Union"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben van Ommen is a senior research fellow at the TNO Quality of Life Research Institute and Director of the NuGO network of excellence funded by the European Union","institution_ids":["https://openalex.org/I1320481043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027338923","display_name":"Andreas P. Freidig","orcid":null},"institutions":[{"id":"https://openalex.org/I4210124573","display_name":"Ark Therapeutic (United States)","ror":"https://ror.org/02tp79578","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. P. Freidig","raw_affiliation_strings":["Andreas Freidig is now a project manager at Amsterdam Molecular Therapeutics after working at the TNO Quality of Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andreas Freidig is now a project manager at Amsterdam Molecular Therapeutics after working at the TNO Quality of Life Research Institute","institution_ids":["https://openalex.org/I4210124573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111984254","display_name":"Eugene P. van Someren","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"E. P. van Someren","raw_affiliation_strings":["Eugene van Someren is a research scientist in bioinformatics at the TNO Quality of Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eugene van Someren is a research scientist in bioinformatics at the TNO Quality of Life Research Institute","institution_ids":["https://openalex.org/I4210148697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038766778","display_name":"J. van der Greef","orcid":null},"institutions":[{"id":"https://openalex.org/I4210149190","display_name":"Analytical Biosciences (China)","ror":"https://ror.org/05wry3r65","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210149190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. van der Greef","raw_affiliation_strings":["Jan van der Greef is a Professor of the Analytical Sciences division at the Leiden Amsterdam Centre for Drug Research at Leiden University. He also leads systems biology research at the TNO Quality of Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jan van der Greef is a Professor of the Analytical Sciences division at the Leiden Amsterdam Centre for Drug Research at Leiden University. He also leads systems biology research at the TNO Quality of Life Research Institute","institution_ids":["https://openalex.org/I4210149190"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002560487","display_name":"Albert A. de Graaf","orcid":"https://orcid.org/0000-0002-1067-3570"},"institutions":[{"id":"https://openalex.org/I4210133322","display_name":"Quality of Life Research Center","ror":"https://ror.org/03hvygv29","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210133322"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A. A. de Graaf","raw_affiliation_strings":["Albert de Graaf leads the computational modelling effort at the TNO Quality of Life Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert de Graaf leads the computational modelling effort at the TNO Quality of Life Research Institute","institution_ids":["https://openalex.org/I4210133322"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":null,"fwci":0.374,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61205859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":"4","first_page":"403","last_page":"416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.7343251705169678},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6987676620483398},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4965665936470032},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.4947218596935272},{"id":"https://openalex.org/keywords/structuring","display_name":"Structuring","score":0.41056862473487854},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.3758230209350586},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2475849688053131},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1239822506904602}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7343251705169678},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6987676620483398},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4965665936470032},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4947218596935272},{"id":"https://openalex.org/C2775945657","wikidata":"https://www.wikidata.org/wiki/Q381442","display_name":"Structuring","level":2,"score":0.41056862473487854},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3758230209350586},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2475849688053131},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1239822506904602},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003933","descriptor_name":"Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003933","descriptor_name":"Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003933","descriptor_name":"Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbp071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp071","pdf_url":"https://academic.oup.com/bib/article-pdf/11/4/403/623970/bbp071.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20056728","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20056728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbp071","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp071","pdf_url":"https://academic.oup.com/bib/article-pdf/11/4/403/623970/bbp071.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5600000023841858,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164547064.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W176383636","https://openalex.org/W649285966","https://openalex.org/W1509329028","https://openalex.org/W1935281646","https://openalex.org/W1963522244","https://openalex.org/W1973355122","https://openalex.org/W1982722057","https://openalex.org/W1999743549","https://openalex.org/W2018656616","https://openalex.org/W2020343812","https://openalex.org/W2020383091","https://openalex.org/W2026387613","https://openalex.org/W2038872111","https://openalex.org/W2048760408","https://openalex.org/W2049113945","https://openalex.org/W2051698476","https://openalex.org/W2054851194","https://openalex.org/W2064702770","https://openalex.org/W2075588526","https://openalex.org/W2076472674","https://openalex.org/W2084515830","https://openalex.org/W2087070363","https://openalex.org/W2089286420","https://openalex.org/W2102653059","https://openalex.org/W2103446764","https://openalex.org/W2106343349","https://openalex.org/W2110233269","https://openalex.org/W2116404316","https://openalex.org/W2117625122","https://openalex.org/W2126513998","https://openalex.org/W2127277443","https://openalex.org/W2137038832","https://openalex.org/W2139271231","https://openalex.org/W2142923621","https://openalex.org/W2149677053","https://openalex.org/W2158427148","https://openalex.org/W2162705046","https://openalex.org/W2183415660","https://openalex.org/W2183983473","https://openalex.org/W2185025112","https://openalex.org/W2299767487","https://openalex.org/W2611370172","https://openalex.org/W2986444355","https://openalex.org/W3029645440","https://openalex.org/W3126739944","https://openalex.org/W3143245542","https://openalex.org/W4236135856"],"related_works":["https://openalex.org/W4251394462","https://openalex.org/W1580673008","https://openalex.org/W1510936208","https://openalex.org/W2486167009","https://openalex.org/W1595575899","https://openalex.org/W756498608","https://openalex.org/W2135201366","https://openalex.org/W4285395220","https://openalex.org/W2131947708","https://openalex.org/W4283815787"],"abstract_inverted_index":{"This":[0],"article":[1],"provides":[2],"methodological":[3],"and":[4,28,57,81,124],"technical":[5],"considerations":[6],"to":[7,10,34,43,73,106],"researchers":[8],"starting":[9],"develop":[11],"computational":[12],"model-based":[13,96],"diagnostics":[14],"using":[15],"clinical":[16,63],"chemistry":[17],"data.":[18],"These":[19],"models":[20,54],"are":[21,32,41],"of":[22,38,84,91],"increasing":[23],"importance,":[24],"since":[25],"novel":[26],"metabolomics":[27],"proteomics":[29],"measuring":[30],"technologies":[31],"able":[33],"produce":[35],"large":[36],"amounts":[37],"data":[39,60],"that":[40,69],"difficult":[42],"interpret":[44],"at":[45],"first":[46],"sight,":[47],"but":[48],"have":[49],"high":[50],"diagnostic":[51,97],"potential.":[52],"Computational":[53],"aid":[55],"interpretation":[56],"make":[58],"the":[59,67,78,89],"accessible":[61],"for":[62,99,116],"diagnosis.":[64],"We":[65,87],"discuss":[66],"issues":[68],"a":[70,95,103],"modeller":[71],"has":[72],"take":[74],"into":[75],"account":[76],"during":[77],"design,":[79],"construction":[80],"evaluation":[82],"phases":[83],"model":[85,118,120],"development.":[86],"use":[88],"example":[90],"Particle":[92],"Profiler":[93],"development,":[94],"tool":[98],"lipoprotein":[100],"disorders,":[101],"as":[102],"case":[104,111],"study,":[105],"illustrate":[107],"our":[108],"considerations.":[109],"The":[110],"study":[112],"also":[113],"offers":[114],"techniques":[115],"efficient":[117],"formulation,":[119],"calculation,":[121],"workflow":[122],"structuring":[123],"quality":[125],"control.":[126]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}