{"id":"https://openalex.org/W4392571650","doi":"https://doi.org/10.1093/bib/bbae078","title":"Diff-AMP: tailored designed antimicrobial peptide framework with all-in-one generation, identification, prediction and optimization","display_name":"Diff-AMP: tailored designed antimicrobial peptide framework with all-in-one generation, identification, prediction and optimization","publication_year":2024,"publication_date":"2024-01-22","ids":{"openalex":"https://openalex.org/W4392571650","doi":"https://doi.org/10.1093/bib/bbae078","pmid":"https://pubmed.ncbi.nlm.nih.gov/38446739"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae078","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae078/56858804/bbae078.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae078/56858804/bbae078.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100431117","display_name":"Rui Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I146620803","display_name":"Wenzhou University","ror":"https://ror.org/020hxh324","country_code":"CN","type":"education","lineage":["https://openalex.org/I146620803"]},{"id":"https://openalex.org/I4400573270","display_name":"Wenzhou University of Technology","ror":"https://ror.org/03dd7qj98","country_code":null,"type":"education","lineage":["https://openalex.org/I4400573270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China","institution_ids":["https://openalex.org/I146620803","https://openalex.org/I4400573270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453693","display_name":"Tao Wang","orcid":"https://orcid.org/0000-0003-3111-2024"},"institutions":[{"id":"https://openalex.org/I4400573270","display_name":"Wenzhou University of Technology","ror":"https://ror.org/03dd7qj98","country_code":null,"type":"education","lineage":["https://openalex.org/I4400573270"]},{"id":"https://openalex.org/I146620803","display_name":"Wenzhou University","ror":"https://ror.org/020hxh324","country_code":"CN","type":"education","lineage":["https://openalex.org/I146620803"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China","institution_ids":["https://openalex.org/I146620803","https://openalex.org/I4400573270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004683765","display_name":"Linlin Zhuo","orcid":"https://orcid.org/0000-0002-6586-0533"},"institutions":[{"id":"https://openalex.org/I4400573270","display_name":"Wenzhou University of Technology","ror":"https://ror.org/03dd7qj98","country_code":null,"type":"education","lineage":["https://openalex.org/I4400573270"]},{"id":"https://openalex.org/I146620803","display_name":"Wenzhou University","ror":"https://ror.org/020hxh324","country_code":"CN","type":"education","lineage":["https://openalex.org/I146620803"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linlin Zhuo","raw_affiliation_strings":["School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China","institution_ids":["https://openalex.org/I146620803","https://openalex.org/I4400573270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025402144","display_name":"Jinhang Wei","orcid":"https://orcid.org/0009-0003-6957-3472"},"institutions":[{"id":"https://openalex.org/I4400573270","display_name":"Wenzhou University of Technology","ror":"https://ror.org/03dd7qj98","country_code":null,"type":"education","lineage":["https://openalex.org/I4400573270"]},{"id":"https://openalex.org/I146620803","display_name":"Wenzhou University","ror":"https://ror.org/020hxh324","country_code":"CN","type":"education","lineage":["https://openalex.org/I146620803"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhang Wei","raw_affiliation_strings":["School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Data Science and Artificial Intelligence, Wenzhou University of Technology , 325000 Wenzhou , China","institution_ids":["https://openalex.org/I146620803","https://openalex.org/I4400573270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044283271","display_name":"Xiangzheng Fu","orcid":"https://orcid.org/0000-0001-6840-2573"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangzheng Fu","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University , 410012 Changsha , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University , 410012 Changsha , China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017426085","display_name":"Quan Zou","orcid":"https://orcid.org/0000-0001-6406-1142"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quan Zou","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China , 611730 Chengdu , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China , 611730 Chengdu , China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101655869","display_name":"Xiaojun Yao","orcid":"https://orcid.org/0000-0001-9958-8438"},"institutions":[{"id":"https://openalex.org/I49835588","display_name":"Macao Polytechnic University","ror":"https://ror.org/02sf5td35","country_code":"MO","type":"education","lineage":["https://openalex.org/I49835588"]}],"countries":["MO"],"is_corresponding":true,"raw_author_name":"Xiaojun Yao","raw_affiliation_strings":["Faculty of Applied Sciences, Macao Polytechnic University , 999078 Macao , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Applied Sciences, Macao Polytechnic University , 999078 Macao , China","institution_ids":["https://openalex.org/I49835588"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5004683765","https://openalex.org/A5017426085","https://openalex.org/A5044283271","https://openalex.org/A5101655869"],"corresponding_institution_ids":["https://openalex.org/I146620803","https://openalex.org/I150229711","https://openalex.org/I16609230","https://openalex.org/I4400573270","https://openalex.org/I49835588"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":22.8661,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.99757376,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7835765480995178},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6745709180831909},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6195429563522339},{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"Reinforcement learning","score":0.5866641402244568},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5829490423202515},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"Antimicrobial peptides","score":0.5714223384857178},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.48767197132110596},{"id":"https://openalex.org/keywords/interdependence","display_name":"Interdependence","score":0.4464673697948456},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43783992528915405},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.4323325455188751},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.15957581996917725},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.10113883018493652},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.09869298338890076},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08063611388206482}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7835765480995178},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6745709180831909},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6195429563522339},{"id":"https://openalex.org/C97541855","wikidata":"https://www.wikidata.org/wiki/Q830687","display_name":"Reinforcement learning","level":2,"score":0.5866641402244568},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5829490423202515},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.5714223384857178},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.48767197132110596},{"id":"https://openalex.org/C185874996","wikidata":"https://www.wikidata.org/wiki/Q269699","display_name":"Interdependence","level":2,"score":0.4464673697948456},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43783992528915405},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.4323325455188751},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.15957581996917725},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10113883018493652},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.09869298338890076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08063611388206482},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae078","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae078/56858804/bbae078.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38446739","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38446739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10939340","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10939340","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10939340/pdf/bbae078.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbae078","pdf_url":"https://academic.oup.com/bib/article-pdf/25/2/bbae078/56858804/bbae078.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5799999833106995}],"awards":[{"id":"https://openalex.org/G552737822","display_name":null,"funder_award_id":"62372158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7363650575","display_name":null,"funder_award_id":"62002111","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4392571650.pdf"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1964937304","https://openalex.org/W1997152791","https://openalex.org/W1998064689","https://openalex.org/W2000788400","https://openalex.org/W2037178359","https://openalex.org/W2054602599","https://openalex.org/W2058037164","https://openalex.org/W2059971420","https://openalex.org/W2066275795","https://openalex.org/W2074726906","https://openalex.org/W2083501076","https://openalex.org/W2084845164","https://openalex.org/W2086798171","https://openalex.org/W2092643722","https://openalex.org/W2097099115","https://openalex.org/W2102786297","https://openalex.org/W2123696501","https://openalex.org/W2129115651","https://openalex.org/W2140501815","https://openalex.org/W2141104259","https://openalex.org/W2141682747","https://openalex.org/W2163251457","https://openalex.org/W2189116376","https://openalex.org/W2194775991","https://openalex.org/W2342838938","https://openalex.org/W2511835277","https://openalex.org/W2739980134","https://openalex.org/W2791848964","https://openalex.org/W2902652978","https://openalex.org/W2913423296","https://openalex.org/W2917874934","https://openalex.org/W2965612550","https://openalex.org/W2984592028","https://openalex.org/W3023413280","https://openalex.org/W3025501158","https://openalex.org/W3027325047","https://openalex.org/W3034806393","https://openalex.org/W3045294277","https://openalex.org/W3081615418","https://openalex.org/W3094708881","https://openalex.org/W3096831136","https://openalex.org/W3117992890","https://openalex.org/W3135156311","https://openalex.org/W3145130117","https://openalex.org/W3154318479","https://openalex.org/W3164453494","https://openalex.org/W3164941572","https://openalex.org/W3172532482","https://openalex.org/W3174864715","https://openalex.org/W3177828909","https://openalex.org/W3188372451","https://openalex.org/W3216979156","https://openalex.org/W3217347090","https://openalex.org/W4206816857","https://openalex.org/W4213077304","https://openalex.org/W4214943162","https://openalex.org/W4220952154","https://openalex.org/W4226148785","https://openalex.org/W4308052938","https://openalex.org/W4308370073","https://openalex.org/W4308834846","https://openalex.org/W4309578061","https://openalex.org/W4317942129","https://openalex.org/W4322718303","https://openalex.org/W4324344300","https://openalex.org/W4327550249","https://openalex.org/W4382198814","https://openalex.org/W6637373629","https://openalex.org/W6640963894","https://openalex.org/W6686723365","https://openalex.org/W6756979132","https://openalex.org/W6766860405","https://openalex.org/W6779342232","https://openalex.org/W6806209084"],"related_works":["https://openalex.org/W2139079562","https://openalex.org/W2749324135","https://openalex.org/W2908433117","https://openalex.org/W2969604939","https://openalex.org/W2378306841","https://openalex.org/W114687057","https://openalex.org/W3122988618","https://openalex.org/W1994631104","https://openalex.org/W4306904969","https://openalex.org/W3146908316"],"abstract_inverted_index":{"Antimicrobial":[0],"peptides":[1,4],"(AMPs),":[2],"short":[3],"with":[5,175],"diverse":[6,150],"functions,":[7],"effectively":[8],"target":[9],"and":[10,32,77,96,104,122,130,141,160,178],"combat":[11],"various":[12],"organisms.":[13],"The":[14],"widespread":[15],"misuse":[16],"of":[17],"chemical":[18],"antibiotics":[19],"has":[20],"led":[21],"to":[22,27,69,148],"increasing":[23],"microbial":[24],"resistance.":[25],"Due":[26],"their":[28],"low":[29],"drug":[30],"resistance":[31],"toxicity,":[33],"AMPs":[34],"are":[35],"considered":[36],"promising":[37],"substitutes":[38],"for":[39,112,126,138],"traditional":[40],"antibiotics.":[41],"While":[42],"existing":[43],"deep":[44,85],"learning":[45,86,110,124],"technology":[46],"enhances":[47],"AMP":[48,56,91,114,128,164],"generation,":[49,92,156],"it":[50],"also":[51,168],"presents":[52],"certain":[53],"challenges.":[54],"Firstly,":[55],"generation":[57],"overlooks":[58],"the":[59,108,183],"complex":[60],"interdependencies":[61],"among":[62],"amino":[63],"acids.":[64],"Secondly,":[65],"current":[66],"models":[67],"fail":[68],"integrate":[70,101],"crucial":[71],"tasks":[72],"like":[73],"screening,":[74,157],"attribute":[75,94,158],"prediction":[76,95,118,140,159],"iterative":[78,97,145],"optimization.":[79,98],"Consequently,":[80],"we":[81],"develop":[82],"a":[83,134,142,172],"integrated":[84],"framework,":[87],"Diff-AMP,":[88],"that":[89],"automates":[90,154],"identification,":[93],"We":[99,132,166],"innovatively":[100],"kinetic":[102],"diffusion":[103],"attention":[105],"mechanisms":[106],"into":[107],"reinforcement":[109,143],"framework":[111,153],"efficient":[113],"generation.":[115],"Additionally,":[116],"our":[117],"module":[119],"incorporates":[120],"pre-training":[121],"transfer":[123],"strategies":[125],"precise":[127],"identification":[129],"screening.":[131],"employ":[133],"convolutional":[135],"neural":[136],"network":[137],"multi-attribute":[139],"learning-based":[144],"optimization":[146],"strategy":[147],"produce":[149],"AMPs.":[151],"This":[152],"molecule":[155],"optimization,":[161],"thereby":[162],"advancing":[163],"research.":[165],"have":[167],"deployed":[169],"Diff-AMP":[170],"on":[171],"web":[173],"server,":[174],"code,":[176],"data":[177],"server":[179],"details":[180],"available":[181],"in":[182],"Data":[184],"Availability":[185],"section.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":49},{"year":2024,"cited_by_count":16}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}