{"id":"https://openalex.org/W2982368177","doi":"https://doi.org/10.1093/nar/gkz949","title":"SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update","display_name":"SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update","publication_year":2019,"publication_date":"2019-10-09","ids":{"openalex":"https://openalex.org/W2982368177","doi":"https://doi.org/10.1093/nar/gkz949","mag":"2982368177","pmid":"https://pubmed.ncbi.nlm.nih.gov/31665520"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkz949","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz949","pdf_url":"https://academic.oup.com/nar/article-pdf/48/D1/D504/31697942/gkz949.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/48/D1/D504/31697942/gkz949.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047929947","display_name":"Luana Licata","orcid":"https://orcid.org/0000-0001-5084-9000"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luana Licata","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073841887","display_name":"Prisca Lo Surdo","orcid":"https://orcid.org/0009-0000-6879-5135"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Prisca Lo\u00a0Surdo","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074813617","display_name":"Marta Iannuccelli","orcid":"https://orcid.org/0000-0002-2374-3531"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Iannuccelli","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088279554","display_name":"Alessandro Palma","orcid":"https://orcid.org/0000-0003-1300-5479"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Palma","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021066316","display_name":"Elisa Micarelli","orcid":"https://orcid.org/0000-0002-1180-0359"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Micarelli","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050128493","display_name":"Livia Perfetto","orcid":"https://orcid.org/0000-0003-4392-8725"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Livia Perfetto","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079580341","display_name":"Daniele Peluso","orcid":"https://orcid.org/0000-0001-9019-1282"},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Peluso","raw_affiliation_strings":["IRCSS Fondazione Santa Lucia, 00142 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"IRCSS Fondazione Santa Lucia, 00142 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083483860","display_name":"Alberto Calderone","orcid":"https://orcid.org/0000-0003-0876-1595"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Calderone","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018540028","display_name":"Luisa Castagnoli","orcid":"https://orcid.org/0000-0001-5283-8671"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa Castagnoli","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029338279","display_name":"Gianni Cesareni","orcid":"https://orcid.org/0000-0002-9528-6018"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianni Cesareni","raw_affiliation_strings":["Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","IRCSS Fondazione Santa Lucia, 00142 Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"IRCSS Fondazione Santa Lucia, 00142 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5029338279","https://openalex.org/A5047929947"],"corresponding_institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4210150112"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":11.735,"has_fulltext":false,"cited_by_count":228,"citation_normalized_percentile":{"value":0.99141127,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"48","issue":"D1","first_page":"D504","last_page":"D510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identifier","display_name":"Identifier","score":0.7589242458343506},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.740965723991394},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.5215749144554138},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.42570945620536804},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.41186076402664185},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4086756408214569},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37207552790641785},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.246027410030365},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21750253438949585}],"concepts":[{"id":"https://openalex.org/C154504017","wikidata":"https://www.wikidata.org/wiki/Q853614","display_name":"Identifier","level":2,"score":0.7589242458343506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.740965723991394},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.5215749144554138},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.42570945620536804},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.41186076402664185},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4086756408214569},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37207552790641785},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.246027410030365},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21750253438949585},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkz949","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz949","pdf_url":"https://academic.oup.com/nar/article-pdf/48/D1/D504/31697942/gkz949.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:31665520","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31665520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:art.torvergata.it:2108/234349","is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/234349","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1660179","is_oa":true,"landing_page_url":"https://hdl.handle.net/11573/1660179","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7145695","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7145695","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkz949","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz949","pdf_url":"https://academic.oup.com/nar/article-pdf/48/D1/D504/31697942/gkz949.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G3407386927","display_name":null,"funder_award_id":"18137","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G7508424624","display_name":null,"funder_award_id":"20322","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2982368177.pdf","grobid_xml":"https://content.openalex.org/works/W2982368177.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1490161904","https://openalex.org/W1894267660","https://openalex.org/W1935434993","https://openalex.org/W1995683190","https://openalex.org/W2006933206","https://openalex.org/W2030530458","https://openalex.org/W2042056286","https://openalex.org/W2064145492","https://openalex.org/W2103017472","https://openalex.org/W2117692326","https://openalex.org/W2125984976","https://openalex.org/W2127589936","https://openalex.org/W2159675211","https://openalex.org/W2163480486","https://openalex.org/W2302501749","https://openalex.org/W2312674677","https://openalex.org/W2436103310","https://openalex.org/W2557833574","https://openalex.org/W2559588208","https://openalex.org/W2585898252","https://openalex.org/W2727134083","https://openalex.org/W2762853387","https://openalex.org/W2763145619","https://openalex.org/W2767891136","https://openalex.org/W2771328536","https://openalex.org/W2773787581","https://openalex.org/W2785792383","https://openalex.org/W2791711117","https://openalex.org/W2894573839","https://openalex.org/W2898440040","https://openalex.org/W2899070097","https://openalex.org/W2899798803","https://openalex.org/W2899903294","https://openalex.org/W2917858269","https://openalex.org/W2946861851","https://openalex.org/W2952583574","https://openalex.org/W2972080603","https://openalex.org/W3136918052","https://openalex.org/W4253785452"],"related_works":["https://openalex.org/W4378651134","https://openalex.org/W1979633005","https://openalex.org/W2352307597","https://openalex.org/W2163724607","https://openalex.org/W1980092392","https://openalex.org/W2608983118","https://openalex.org/W4318812462","https://openalex.org/W37347591","https://openalex.org/W2118976126","https://openalex.org/W1712642469"],"abstract_inverted_index":{"The":[0,23,159],"SIGnaling":[1],"Network":[2],"Open":[3],"Resource":[4],"2.0":[5,82],"(SIGNOR":[6],"2.0)":[7],"is":[8,26,37,116],"a":[9,30,67,111],"public":[10],"repository":[11],"that":[12],"stores":[13,84],"signaling":[14,35],"information":[15,25],"as":[16,29,154],"binary":[17],"causal":[18,76,89],"relationships":[19,90],"between":[20,91],"biological":[21],"entities.":[22],"captured":[24],"represented":[27],"graphically":[28],"signed":[31],"directed":[32],"graph.":[33],"Each":[34],"relationship":[36],"associated":[38],"to":[39,44,118,127],"an":[40],"effect":[41],"(up/down-regulation)":[42],"and":[43,71,93,110,146,157,164],"the":[45,54,57,72,125,128],"mechanism":[46],"(e.g.":[47],"binding,":[48],"phosphorylation,":[49],"transcriptional":[50],"activation,":[51],"etc.)":[52],"causing":[53],"up/down-regulation":[55],"of":[56,74],"target":[58],"entity.":[59],"Since":[60],"its":[61],"first":[62],"release,":[63],"SIGNOR":[64,81,135],"has":[65],"undergone":[66],"significant":[68,105],"content":[69],"increase":[70],"number":[73],"annotated":[75],"interactions":[77],"have":[78,122],"almost":[79,85],"doubled.":[80],"now":[83],"23":[86],"000":[87],"manually-annotated":[88],"proteins":[92],"other":[94],"biologically":[95],"relevant":[96],"entities:":[97],"chemicals,":[98],"phenotypes,":[99],"complexes,":[100],"etc.":[101],"We":[102,121],"describe":[103],"here":[104],"changes":[106],"in":[107,150],"curation":[108],"policy":[109],"new":[112],"confidence":[113],"score,":[114],"which":[115],"assigned":[117],"each":[119],"interaction.":[120],"also":[123],"improved":[124],"compliance":[126],"FAIR":[129],"data":[130,149,160],"principles":[131],"by":[132],"providing":[133],"(i)":[134],"stable":[136],"identifiers,":[137],"(ii)":[138],"programmatic":[139],"access":[140],"through":[141],"REST":[142],"APIs,":[143],"(iii)":[144],"bioschemas":[145],"(iv)":[147],"downloadable":[148,165],"standard-compliant":[151],"formats,":[152],"such":[153],"PSI-MI":[155],"CausalTAB":[156],"GMT.":[158],"are":[161],"freely":[162],"accessible":[163],"at":[166],"https://signor.uniroma2.it/.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":38},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":1}],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2025-10-10T00:00:00"}