{"id":"https://openalex.org/W2982225121","doi":"https://doi.org/10.1093/nar/gkz793","title":"SNP2APA: a database for evaluating effects of genetic variants on alternative polyadenylation in human cancers","display_name":"SNP2APA: a database for evaluating effects of genetic variants on alternative polyadenylation in human cancers","publication_year":2019,"publication_date":"2019-09-06","ids":{"openalex":"https://openalex.org/W2982225121","doi":"https://doi.org/10.1093/nar/gkz793","mag":"2982225121","pmid":"https://pubmed.ncbi.nlm.nih.gov/31511885"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkz793","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz793","pdf_url":"https://academic.oup.com/nar/article-pdf/48/D1/D226/31697189/gkz793.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/48/D1/D226/31697189/gkz793.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103201823","display_name":"Yanbo Yang","orcid":"https://orcid.org/0000-0003-1532-9274"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanbo Yang","raw_affiliation_strings":["Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407278","display_name":"Qiong Zhang","orcid":"https://orcid.org/0000-0001-5001-8434"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Zhang","raw_affiliation_strings":["Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015509831","display_name":"Ya\u2010Ru Miao","orcid":null},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Ru Miao","raw_affiliation_strings":["Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732771","display_name":"Jiajun Yang","orcid":"https://orcid.org/0000-0002-0922-3783"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajun Yang","raw_affiliation_strings":["Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103104072","display_name":"Wenqian Yang","orcid":"https://orcid.org/0000-0001-9349-2240"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenqian Yang","raw_affiliation_strings":["Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062246340","display_name":"Fangda Yu","orcid":"https://orcid.org/0000-0001-8288-3350"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangda Yu","raw_affiliation_strings":["Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108047343","display_name":"Dongyang Wang","orcid":"https://orcid.org/0000-0002-1887-4326"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongyang Wang","raw_affiliation_strings":["Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009558607","display_name":"An\u2010Yuan Guo","orcid":"https://orcid.org/0000-0002-5099-7465"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"An-Yuan Guo","raw_affiliation_strings":["Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022557533","display_name":"Jing Gong","orcid":"https://orcid.org/0000-0003-1895-2993"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Gong","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, P. R. China","Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, P. R. China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P. R. China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5009558607","https://openalex.org/A5022557533"],"corresponding_institution_ids":["https://openalex.org/I204823248","https://openalex.org/I47720641"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":2.3934,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.89733567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"48","issue":"D1","first_page":"D226","last_page":"D232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8451449871063232},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7380738258361816},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"Polyadenylation","score":0.7262908220291138},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6973547339439392},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6223737001419067},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5562745928764343},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5127524137496948},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.4575274884700775},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.4570063352584839},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.4458242952823639},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.42130163311958313},{"id":"https://openalex.org/keywords/three-prime-untranslated-region","display_name":"Three prime untranslated region","score":0.421015202999115},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.39388328790664673},{"id":"https://openalex.org/keywords/untranslated-region","display_name":"Untranslated region","score":0.37164872884750366},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3007841110229492},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24145618081092834},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10047957301139832},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.08755627274513245}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8451449871063232},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7380738258361816},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.7262908220291138},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6973547339439392},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6223737001419067},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5562745928764343},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5127524137496948},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4575274884700775},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.4570063352584839},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4458242952823639},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42130163311958313},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.421015202999115},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.39388328790664673},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.37164872884750366},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3007841110229492},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24145618081092834},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10047957301139832},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.08755627274513245}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkz793","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz793","pdf_url":"https://academic.oup.com/nar/article-pdf/48/D1/D226/31697189/gkz793.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:31511885","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31511885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:5903240","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkz793","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz793","pdf_url":"https://academic.oup.com/nar/article-pdf/48/D1/D226/31697189/gkz793.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2071878295","display_name":null,"funder_award_id":"31822030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2735961896","display_name":"\u591a\u79cd\u764c\u75c7\u4e2d\u9057\u4f20\u53d8\u5f02\u5bf9\u53ef\u9009\u62e9\u6027\u591a\u805a\u817a\u82f7\u9178\u5316\u5f71\u54cd\u7684\u6df1\u5ea6\u6316\u6398\u53ca\u529f\u80fd\u7814\u7a76","funder_award_id":"31970644","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G632062907","display_name":null,"funder_award_id":"31771458","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1527932829","https://openalex.org/W1533942137","https://openalex.org/W1975635514","https://openalex.org/W1985267020","https://openalex.org/W1986911601","https://openalex.org/W1992436001","https://openalex.org/W2031276095","https://openalex.org/W2036065307","https://openalex.org/W2044702943","https://openalex.org/W2051610800","https://openalex.org/W2077940776","https://openalex.org/W2087789109","https://openalex.org/W2088338354","https://openalex.org/W2091808830","https://openalex.org/W2096283457","https://openalex.org/W2099305989","https://openalex.org/W2100697281","https://openalex.org/W2104549677","https://openalex.org/W2128476271","https://openalex.org/W2135199713","https://openalex.org/W2152494705","https://openalex.org/W2157752701","https://openalex.org/W2165260680","https://openalex.org/W2275768091","https://openalex.org/W2340588071","https://openalex.org/W2461965332","https://openalex.org/W2525507785","https://openalex.org/W2559028527","https://openalex.org/W2560367415","https://openalex.org/W2593747486","https://openalex.org/W2626966859","https://openalex.org/W2760366406","https://openalex.org/W2765241807","https://openalex.org/W2765253743","https://openalex.org/W2767329525","https://openalex.org/W2776687758","https://openalex.org/W2786594082","https://openalex.org/W2890965399","https://openalex.org/W2920773417","https://openalex.org/W2950718985","https://openalex.org/W3029457946"],"related_works":["https://openalex.org/W1972892146","https://openalex.org/W2100045083","https://openalex.org/W2989167897","https://openalex.org/W4310602063","https://openalex.org/W3052406843","https://openalex.org/W2203433820","https://openalex.org/W2258906660","https://openalex.org/W2028523669","https://openalex.org/W2912212935","https://openalex.org/W3106159324"],"abstract_inverted_index":{"Alternative":[0],"polyadenylation":[1,11],"(APA)":[2],"is":[3],"an":[4,152],"important":[5],"post-transcriptional":[6],"regulation":[7],"that":[8,35],"recognizes":[9],"different":[10,18],"signals":[12],"(PASs),":[13],"resulting":[14],"in":[15,57,145,196],"transcripts":[16],"with":[17,122,136],"3'":[19],"untranslated":[20],"regions,":[21],"thereby":[22],"influencing":[23],"a":[24,105,107,173],"series":[25],"of":[26,69,109,159,191],"biological":[27],"processes":[28],"and":[29,45,55,66,78,95,113,124,140,175,183,194],"functions.":[30],"Recent":[31],"studies":[32,127],"have":[33],"revealed":[34],"some":[36],"single":[37],"nucleotide":[38],"polymorphisms":[39],"(SNPs)":[40],"could":[41],"contribute":[42],"to":[43,155],"tumorigenesis":[44],"development":[46],"through":[47],"dysregulating":[48],"APA.":[49],"However,":[50],"the":[51,157],"associations":[52],"between":[53],"SNPs":[54,87,160],"APA":[56,67,89,99,195],"human":[58,197],"cancers":[59],"remain":[60],"largely":[61],"unknown.":[62],"Here,":[63],"using":[64],"genotype":[65],"data":[68,180],"9082":[70],"samples":[71],"from":[72],"The":[73,79],"Cancer":[74,80],"Genome":[75],"Atlas":[76],"(TCGA)":[77],"3'UTR":[81],"Altas":[82],"(TC3A),":[83],"we":[84,130,150,170],"systematically":[85],"identified":[86,132],"affecting":[88],"events":[90],"across":[91],"32":[92],"cancer":[93],"types":[94],"defined":[96],"them":[97],"as":[98],"quantitative":[100],"trait":[101],"loci":[102],"(apaQTLs).":[103],"As":[104],"result,":[106],"total":[108],"467":[110],"942":[111],"cis-apaQTLs":[112],"30":[114],"721":[115],"trans-apaQTLs":[116],"were":[117],"identified.":[118],"By":[119],"integrating":[120],"apaQTLs":[121,134,143],"survival":[123,138],"genome-wide":[125],"association":[126],"(GWAS)":[128],"data,":[129],"further":[131],"2154":[133],"associated":[135],"patient":[137],"time":[139],"151":[141],"342":[142],"located":[144],"GWAS":[146],"loci.":[147],"In":[148],"addition,":[149],"designed":[151],"online":[153],"tool":[154],"predict":[156],"effects":[158],"on":[161],"PASs":[162],"by":[163],"utilizing":[164],"PAS":[165],"motif":[166],"prediction":[167],"tool.":[168],"Finally,":[169],"developed":[171],"SNP2APA,":[172],"user-friendly":[174],"intuitive":[176],"database":[177],"(http://gong_lab.hzau.edu.cn/SNP2APA/)":[178],"for":[179],"browsing,":[181],"searching,":[182],"downloading.":[184],"SNP2APA":[185],"will":[186],"significantly":[187],"improve":[188],"our":[189],"understanding":[190],"genetic":[192],"variants":[193],"cancers.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}