{"id":"https://openalex.org/W2955500742","doi":"https://doi.org/10.1093/nar/gkz457","title":"MTR-Viewer: identifying regions within genes under purifying selection","display_name":"MTR-Viewer: identifying regions within genes under purifying selection","publication_year":2019,"publication_date":"2019-06-03","ids":{"openalex":"https://openalex.org/W2955500742","doi":"https://doi.org/10.1093/nar/gkz457","mag":"2955500742","pmid":"https://pubmed.ncbi.nlm.nih.gov/31170280"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkz457","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz457","pdf_url":"https://academic.oup.com/nar/article-pdf/47/W1/W121/28880302/gkz457.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/47/W1/W121/28880302/gkz457.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017262841","display_name":"Michael Silk","orcid":"https://orcid.org/0000-0001-5855-8750"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2799503646","display_name":"Australian Cancer Research Foundation","ror":"https://ror.org/0459phn12","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I2799503646"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Silk","raw_affiliation_strings":["ACRF Facility for Innovative Cancer Drug Discovery, Bio21 Institute, University of Melbourne,\u00a0Melbourne,\u00a0VIC\u00a03052, Australia","Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne,\u00a0VIC\u00a03052, Australia","Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne, VIC\u00a03004, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Facility for Innovative Cancer Drug Discovery, Bio21 Institute, University of Melbourne,\u00a0Melbourne,\u00a0VIC\u00a03052, Australia","institution_ids":["https://openalex.org/I2799503646","https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne,\u00a0VIC\u00a03052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne, VIC\u00a03004, Australia","institution_ids":["https://openalex.org/I142471025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103190944","display_name":"Slav\u00e9 Petrovski","orcid":"https://orcid.org/0000-0002-1527-961X"},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]},{"id":"https://openalex.org/I4210163497","display_name":"Austin Health","ror":"https://ror.org/05dbj6g52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163497"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Slav\u00e9 Petrovski","raw_affiliation_strings":["Centre for Genomics Research, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Cambridge, UK","Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, VIC\u00a03050, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomics Research, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370","https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, VIC\u00a03050, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210163497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091903225","display_name":"David B. Ascher","orcid":"https://orcid.org/0000-0003-2948-2413"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2799503646","display_name":"Australian Cancer Research Foundation","ror":"https://ror.org/0459phn12","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I2799503646"]}],"countries":["AU","GB"],"is_corresponding":true,"raw_author_name":"David B Ascher","raw_affiliation_strings":["ACRF Facility for Innovative Cancer Drug Discovery, Bio21 Institute, University of Melbourne,\u00a0Melbourne,\u00a0VIC\u00a03052, Australia","Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne,\u00a0VIC\u00a03052, Australia","Department of Biochemistry, University of Cambridge; Cambridge CB2 1GA, UK","Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne, VIC\u00a03004, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2948-2413","affiliations":[{"raw_affiliation_string":"ACRF Facility for Innovative Cancer Drug Discovery, Bio21 Institute, University of Melbourne,\u00a0Melbourne,\u00a0VIC\u00a03052, Australia","institution_ids":["https://openalex.org/I2799503646","https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne,\u00a0VIC\u00a03052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge; Cambridge CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne, VIC\u00a03004, Australia","institution_ids":["https://openalex.org/I142471025"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091903225"],"corresponding_institution_ids":["https://openalex.org/I142471025","https://openalex.org/I165779595","https://openalex.org/I241749","https://openalex.org/I2799503646"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":5.5606,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.96115032,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"47","issue":"W1","first_page":"W121","last_page":"W126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9438841342926025},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5824277400970459},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5143505334854126},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4961910843849182},{"id":"https://openalex.org/keywords/negative-selection","display_name":"Negative selection","score":0.44738319516181946},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44384124875068665},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4065796434879303},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.26384180784225464},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09701117873191833}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9438841342926025},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5824277400970459},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5143505334854126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4961910843849182},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.44738319516181946},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44384124875068665},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4065796434879303},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.26384180784225464},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09701117873191833},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gkz457","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz457","pdf_url":"https://academic.oup.com/nar/article-pdf/47/W1/W121/28880302/gkz457.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:31170280","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31170280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/227473","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/227473","pdf_url":"http://hdl.handle.net/11343/227473","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5577318","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6602522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/292842","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/292842","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.39994","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.39994","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/nar/gkz457","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz457","pdf_url":"https://academic.oup.com/nar/article-pdf/47/W1/W121/28880302/gkz457.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1641483229","display_name":"Newton001 Understanding Antimicrobial Resistance Mutations in Tuberculosis: Towards Personalised Treatment to Combat Multi-drug Resistance","funder_award_id":"MR/M026302/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3800037585","display_name":null,"funder_award_id":"1126877","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4753511726","display_name":null,"funder_award_id":"JBF 4186","funder_id":"https://openalex.org/F4320313734","funder_display_name":"Jack Brockhoff Foundation"},{"id":"https://openalex.org/G6599943155","display_name":null,"funder_award_id":"APP1072476","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320313734","display_name":"Jack Brockhoff Foundation","ror":"https://ror.org/02ybsyy31"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320320974","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98"},{"id":"https://openalex.org/F4320330584","display_name":"Conselho Nacional das Funda\u00e7\u00f5es Estaduais de Amparo \u00e0 Pesquisa","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2955500742.pdf","grobid_xml":"https://content.openalex.org/works/W2955500742.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1964426200","https://openalex.org/W2010595044","https://openalex.org/W2082704080","https://openalex.org/W2104549677","https://openalex.org/W2110065044","https://openalex.org/W2119818111","https://openalex.org/W2122732537","https://openalex.org/W2123507520","https://openalex.org/W2147526198","https://openalex.org/W2152745352","https://openalex.org/W2154866190","https://openalex.org/W2160697532","https://openalex.org/W2168533552","https://openalex.org/W2169567789","https://openalex.org/W2173732482","https://openalex.org/W2256016639","https://openalex.org/W2417483443","https://openalex.org/W2476462209","https://openalex.org/W2542446037","https://openalex.org/W2562408240","https://openalex.org/W2625862723","https://openalex.org/W2751117505","https://openalex.org/W2770026599","https://openalex.org/W2894573839","https://openalex.org/W3023863403","https://openalex.org/W3136918052","https://openalex.org/W4248172720"],"related_works":["https://openalex.org/W4205762803","https://openalex.org/W2535856026","https://openalex.org/W2265065644","https://openalex.org/W2134699697","https://openalex.org/W3017188156","https://openalex.org/W2322875716","https://openalex.org/W2383516975","https://openalex.org/W2374878784","https://openalex.org/W2147679489","https://openalex.org/W2159595936"],"abstract_inverted_index":{"Advances":[0],"in":[1],"genomic":[2],"sequencing":[3],"have":[4],"enormous":[5],"potential":[6],"to":[7,68,114,148],"revolutionize":[8],"personalized":[9],"medicine,":[10],"however":[11],"distinguishing":[12],"disease-causing":[13],"from":[14,74],"benign":[15],"variants":[16,135,159],"remains":[17],"a":[18,46,63,199],"challenge.":[19],"The":[20,81,127],"increasing":[21],"number":[22],"of":[23,57,65,85,118,130],"human":[24,96],"genome":[25,79],"and":[26,78,99,132,155,177],"exome":[27,77],"sequences":[28],"available":[29,197],"has":[30],"revealed":[31],"areas":[32],"where":[33],"unfavourable":[34],"variation":[35,70,73],"is":[36,136,171,195],"removed":[37],"through":[38],"purifying":[39],"selection.":[40],"Here,":[41],"we":[42],"present":[43],"the":[44,52,58,140,169],"MTR-Viewer,":[45],"web-server":[47,202],"enabling":[48],"easy":[49,116],"visualization":[50],"at":[51,203],"gene":[53],"or":[54,189],"variant":[55],"level":[56],"Missense":[59],"Tolerance":[60],"Ratio":[61],"(MTR),":[62],"measure":[64],"regional":[66],"intolerance":[67],"missense":[69,158],"calculated":[71,110],"using":[72,88],"240":[75],"000":[76,95,101],"sequences.":[80],"MTR-Viewer":[82,194],"enables":[83],"exploration":[84,117],"MTR":[86,108,170],"calculations,":[87],"different":[89,124],"sliding":[90],"windows,":[91],"for":[92,111,152],"over":[93],"18":[94],"protein-coding":[97],"genes":[98,187],"85":[100],"alternative":[102],"transcripts.":[103],"Users":[104],"can":[105,181],"also":[106,137],"view":[107],"scores":[109],"specific":[112],"ethnicities,":[113],"enable":[115],"regions":[119,145,185],"that":[120],"may":[121],"be":[122,149],"under":[123],"selective":[125],"pressure.":[126],"spatial":[128],"distribution":[129],"population":[131],"known":[133,175],"disease":[134],"displayed":[138],"on":[139],"protein's":[141],"domain":[142],"structure.":[143],"Intolerant":[144],"were":[146],"found":[147],"highly":[150],"enriched":[151],"ClinVar":[153],"pathogenic":[154],"COSMIC":[156],"somatic":[157],"(Mann-Whitney":[160],"U":[161],"test":[162],"P":[163],"<":[164],"2.2":[165],"\u00d7":[166],"10-16).":[167],"As":[168],"not":[172],"biased":[173],"by":[174,191],"domains":[176],"protein":[178],"features,":[179],"it":[180],"highlight":[182],"functionally":[183],"important":[184],"within":[186],"overlooked":[188],"inaccessible":[190],"traditional":[192],"methods.":[193],"freely":[196],"via":[198],"user":[200],"friendly":[201],"http://biosig.unimelb.edu.au/mtr-viewer/.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
