{"id":"https://openalex.org/W2945199349","doi":"https://doi.org/10.1093/nar/gkz391","title":"Drug ReposER: a web server for predicting similar amino acid arrangements to known drug binding interfaces for potential drug repositioning","display_name":"Drug ReposER: a web server for predicting similar amino acid arrangements to known drug binding interfaces for potential drug repositioning","publication_year":2019,"publication_date":"2019-05-02","ids":{"openalex":"https://openalex.org/W2945199349","doi":"https://doi.org/10.1093/nar/gkz391","mag":"2945199349","pmid":"https://pubmed.ncbi.nlm.nih.gov/31106379"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkz391","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz391","pdf_url":"https://academic.oup.com/nar/article-pdf/47/W1/W350/28880290/gkz391.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/47/W1/W350/28880290/gkz391.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018419350","display_name":"Nur Syatila Ab Ghani","orcid":"https://orcid.org/0000-0003-0718-6904"},"institutions":[{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Nur Syatila Ab\u00a0Ghani","raw_affiliation_strings":["Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia","institution_ids":["https://openalex.org/I885383172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014901980","display_name":"Effirul Ikhwan Ramlan","orcid":"https://orcid.org/0000-0002-8150-4782"},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]},{"id":"https://openalex.org/I4210101103","display_name":"Malaysia Genome Institute","ror":"https://ror.org/0138q7t80","country_code":"MY","type":"facility","lineage":["https://openalex.org/I4210101103"]},{"id":"https://openalex.org/I4210114742","display_name":"National Institutes of Biotechnology Malaysia","ror":"https://ror.org/029dygd35","country_code":"MY","type":"government","lineage":["https://openalex.org/I134138859","https://openalex.org/I4210114742"]}],"countries":["GB","MY"],"is_corresponding":false,"raw_author_name":"Effirul Ikhwan Ramlan","raw_affiliation_strings":["Malaysia Genome Institute, National Institutes of Biotechnology Malaysia, Jalan Bangi, 43000 Kajang, Selangor, Malaysia","School of Computing, Engineering and Intelligent Systems, Ulster University, Northlands Road, Magee Campus, Londonderry BT48 7JL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaysia Genome Institute, National Institutes of Biotechnology Malaysia, Jalan Bangi, 43000 Kajang, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210114742","https://openalex.org/I4210101103"]},{"raw_affiliation_string":"School of Computing, Engineering and Intelligent Systems, Ulster University, Northlands Road, Magee Campus, Londonderry BT48 7JL, UK","institution_ids":["https://openalex.org/I138801177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070763648","display_name":"Mohd Firdaus\u2010Raih","orcid":"https://orcid.org/0000-0003-4275-4663"},"institutions":[{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Mohd Firdaus-Raih","raw_affiliation_strings":["Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia","Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia"],"raw_orcid":"https://orcid.org/0000-0003-4275-4663","affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia","institution_ids":["https://openalex.org/I885383172"]},{"raw_affiliation_string":"Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor\u00a043600, Malaysia","institution_ids":["https://openalex.org/I885383172"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070763648"],"corresponding_institution_ids":["https://openalex.org/I885383172"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.2345,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92701352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"47","issue":"W1","first_page":"W350","last_page":"W356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.8417601585388184},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7107506394386292},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6595597863197327},{"id":"https://openalex.org/keywords/web-site","display_name":"Web site","score":0.5768844485282898},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5284758806228638},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.5279998779296875},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5250137448310852},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.5235074162483215},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.46041327714920044},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.44857749342918396},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank","score":0.44050052762031555},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.43427854776382446},{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.41394442319869995},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.30777376890182495},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.2886854112148285},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2302764356136322},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1791456937789917},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16910472512245178},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14862138032913208},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.14570137858390808},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.13935565948486328},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.13579383492469788}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8417601585388184},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7107506394386292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6595597863197327},{"id":"https://openalex.org/C2984519610","wikidata":"https://www.wikidata.org/wiki/Q35127","display_name":"Web site","level":3,"score":0.5768844485282898},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5284758806228638},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.5279998779296875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5250137448310852},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5235074162483215},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.46041327714920044},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.44857749342918396},{"id":"https://openalex.org/C119145174","wikidata":"https://www.wikidata.org/wiki/Q7251429","display_name":"Protein Data Bank","level":3,"score":0.44050052762031555},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.43427854776382446},{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.41394442319869995},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30777376890182495},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2886854112148285},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2302764356136322},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1791456937789917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16910472512245178},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14862138032913208},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.14570137858390808},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13935565948486328},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.13579383492469788},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055553","descriptor_name":"Prescription Drugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055553","descriptor_name":"Prescription Drugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055553","descriptor_name":"Prescription Drugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055553","descriptor_name":"Prescription Drugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055553","descriptor_name":"Prescription Drugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055553","descriptor_name":"Prescription Drugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkz391","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz391","pdf_url":"https://academic.oup.com/nar/article-pdf/47/W1/W350/28880290/gkz391.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:31106379","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31106379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pure.atira.dk:publications/398e1702-6582-4fe7-9720-ed7d2c32508b","is_oa":true,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/398e1702-6582-4fe7-9720-ed7d2c32508b","pdf_url":"https://pure.ulster.ac.uk/en/publications/398e1702-6582-4fe7-9720-ed7d2c32508b","source":{"id":"https://openalex.org/S4306402454","display_name":"Ulster University Research Portal (Ulster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138801177","host_organization_name":"University of Ulster","host_organization_lineage":["https://openalex.org/I138801177"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ab Ghani, N S, Ramlan, E & Firdaus-Raih, M 2019, 'Drug ReposER: a web server for predicting similar amino acid arrangements to known drug binding interfaces for potential drug repositioning', Nucleic Acids Research, vol. 47, no. W1, pp. W350-W356. https://doi.org/10.1093/nar/gkz391","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:5577277","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6602481","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkz391","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz391","pdf_url":"https://academic.oup.com/nar/article-pdf/47/W1/W350/28880290/gkz391.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.4099999964237213}],"awards":[{"id":"https://openalex.org/G1062116381","display_name":null,"funder_award_id":"02-01-02-SF1278","funder_id":"https://openalex.org/F4320321784","funder_display_name":"Kementerian Sains, Teknologi dan Inovasi"},{"id":"https://openalex.org/G2948266335","display_name":null,"funder_award_id":"DIP-2017-013","funder_id":"https://openalex.org/F4320322699","funder_display_name":"Universiti Kebangsaan Malaysia"}],"funders":[{"id":"https://openalex.org/F4320321784","display_name":"Kementerian Sains, Teknologi dan Inovasi","ror":"https://ror.org/012s3r374"},{"id":"https://openalex.org/F4320322699","display_name":"Universiti Kebangsaan Malaysia","ror":"https://ror.org/00bw8d226"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2945199349.pdf"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1970981633","https://openalex.org/W1993595811","https://openalex.org/W2000956292","https://openalex.org/W2011322868","https://openalex.org/W2024993723","https://openalex.org/W2025501637","https://openalex.org/W2025816743","https://openalex.org/W2029124536","https://openalex.org/W2039636022","https://openalex.org/W2045055730","https://openalex.org/W2057649456","https://openalex.org/W2062941476","https://openalex.org/W2063345306","https://openalex.org/W2080754816","https://openalex.org/W2093757149","https://openalex.org/W2096021562","https://openalex.org/W2101078720","https://openalex.org/W2108563067","https://openalex.org/W2110397834","https://openalex.org/W2113494611","https://openalex.org/W2132926880","https://openalex.org/W2161904562","https://openalex.org/W2165535543","https://openalex.org/W2177550115","https://openalex.org/W2278840695","https://openalex.org/W2279376656","https://openalex.org/W2444690946","https://openalex.org/W2545393754","https://openalex.org/W2587939208","https://openalex.org/W2592476227","https://openalex.org/W2611425558","https://openalex.org/W2612436700","https://openalex.org/W2767891136","https://openalex.org/W2787229753","https://openalex.org/W2798245166","https://openalex.org/W2806399642","https://openalex.org/W2898364362","https://openalex.org/W2898402099","https://openalex.org/W6650253026"],"related_works":["https://openalex.org/W4387572939","https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4320009247","https://openalex.org/W4206422705","https://openalex.org/W2991189557","https://openalex.org/W3186872001"],"abstract_inverted_index":{"A":[0,16],"common":[1],"drug":[2,11,92,104,131,160],"repositioning":[3],"strategy":[4],"is":[5,23,33,85,196],"the":[6,25,30,38,43,56,99,118,126,155,177],"re-application":[7],"of":[8,102,129,170,176],"an":[9,183],"existing":[10],"to":[12,19,35,53,64,87,98,125,137,154],"address":[13],"alternative":[14,39,141],"targets.":[15,75,142],"crucial":[17],"aspect":[18],"enable":[20],"such":[21],"repurposing":[22,93],"that":[24,36,45,71,122,150],"drug's":[26],"binding":[27,49,100,105,132,161],"site":[28],"on":[29,37,42,95],"original":[31],"target":[32],"similar":[34,48,54,66,124],"target.":[40],"Based":[41],"assumption":[44],"proteins":[46,70],"with":[47],"sites":[50,67,133,149],"may":[51],"bind":[52],"drugs,":[55],"3D":[57,127],"substructure":[58],"similarity":[59,97],"data":[60],"can":[61,144,179],"be":[62,180],"used":[63],"identify":[65,88],"in":[68,117,158],"other":[69],"are":[72,123,151,166],"not":[73],"known":[74,103,130,159],"The":[76,107,163,174,187],"Drug":[77,188],"ReposER":[78,189],"(DRug":[79],"REPOSitioning":[80],"Exploration":[81],"Resource)":[82],"web":[83],"server":[84,190],"designed":[86],"potential":[89],"targets":[90],"for":[91,148],"based":[94],"sub-structural":[96],"interfaces":[101],"sites.":[106],"application":[108],"has":[109,191],"pre-computed":[110],"amino":[111],"acid":[112],"arrangements":[113,128],"from":[114],"protein":[115],"structures":[116,147],"Protein":[119],"Data":[120],"Bank":[121],"thus":[134],"allowing":[135],"users":[136],"explore":[138],"them":[139],"as":[140,168],"Users":[143],"annotate":[145],"new":[146],"similarly":[152],"arranged":[153],"residues":[156],"found":[157],"interfaces.":[162],"search":[164],"results":[165,175],"presented":[167],"mappings":[169],"matched":[171],"sidechain":[172],"superpositions.":[173],"searches":[178],"visualized":[181],"using":[182],"integrated":[184],"NGL":[185],"viewer.":[186],"no":[192],"access":[193],"restrictions":[194],"and":[195],"available":[197],"at":[198],"http://mfrlab.org/drugreposer/.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2019-05-29T00:00:00"}