{"id":"https://openalex.org/W4231254854","doi":"https://doi.org/10.1093/nar/gkz1031","title":"The reactome pathway knowledgebase","display_name":"The reactome pathway knowledgebase","publication_year":2019,"publication_date":"2019-10-21","ids":{"openalex":"https://openalex.org/W4231254854","doi":"https://doi.org/10.1093/nar/gkz1031"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkz1031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz1031","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkz1031","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045359895","display_name":"Bijay Jassal","orcid":"https://orcid.org/0000-0002-5039-5405"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bijay Jassal","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003520248","display_name":"Lisa Matthews","orcid":"https://orcid.org/0000-0001-5707-3065"},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Matthews","raw_affiliation_strings":["NYU School of Medicine, New York, NY 10016, USA"],"affiliations":[{"raw_affiliation_string":"NYU School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082483580","display_name":"Guilherme Viteri","orcid":"https://orcid.org/0000-0003-0530-4903"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guilherme Viteri","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086133062","display_name":"Chuqiao Gong","orcid":"https://orcid.org/0000-0001-8674-1739"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chuqiao Gong","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063835058","display_name":"Pascual Lorente","orcid":null},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pascual Lorente","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017871846","display_name":"Antonio Fabregat","orcid":"https://orcid.org/0000-0002-3288-8599"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210086966","display_name":"Open Targets","ror":"https://ror.org/000bp7q73","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210086966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonio Fabregat","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I4210086966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087599896","display_name":"Konstantinos Sidiropoulos","orcid":"https://orcid.org/0000-0003-1014-967X"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Konstantinos Sidiropoulos","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026782519","display_name":"Justin Cook","orcid":"https://orcid.org/0000-0003-3457-2552"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Justin Cook","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040546699","display_name":"Marc Gillespie","orcid":"https://orcid.org/0000-0002-5766-1702"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]},{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Marc Gillespie","raw_affiliation_strings":["College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA","Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA","institution_ids":["https://openalex.org/I142823887"]},{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045676311","display_name":"Robin Haw","orcid":"https://orcid.org/0000-0002-2013-7835"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robin Haw","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036915193","display_name":"Fred Loney","orcid":"https://orcid.org/0000-0002-8828-0726"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Loney","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR 97239, USA"],"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036541728","display_name":"Bruce May","orcid":"https://orcid.org/0000-0001-5193-0855"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bruce May","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081289281","display_name":"M Orlic-Milacic","orcid":"https://orcid.org/0000-0002-3218-5631"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marija Milacic","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002658332","display_name":"Karen Rothfels","orcid":"https://orcid.org/0000-0002-0705-7048"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karen Rothfels","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029646676","display_name":"Cristoffer Sevilla","orcid":"https://orcid.org/0000-0002-8570-4650"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cristoffer Sevilla","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056708717","display_name":"Veronica Shamovsky","orcid":"https://orcid.org/0000-0002-2187-2241"},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Shamovsky","raw_affiliation_strings":["NYU School of Medicine, New York, NY 10016, USA"],"affiliations":[{"raw_affiliation_string":"NYU School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032388127","display_name":"Solomon I. Shorser","orcid":null},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Solomon Shorser","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058626872","display_name":"Thawfeek Varusai","orcid":"https://orcid.org/0000-0002-7864-5971"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thawfeek Varusai","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026244391","display_name":"Joel Weiser","orcid":null},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joel Weiser","raw_affiliation_strings":["Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006718188","display_name":"Guanming Wu","orcid":"https://orcid.org/0000-0001-8196-1177"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guanming Wu","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR 97239, USA"],"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052076713","display_name":"Lincoln Stein","orcid":"https://orcid.org/0000-0002-1983-4588"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Lincoln Stein","raw_affiliation_strings":["Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada","Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Ontario Institute for Cancer Research, Toronto, ON\u00a0M5G0A3, Canada","institution_ids":["https://openalex.org/I112260969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066783652","display_name":"Henning Hermjakob","orcid":"https://orcid.org/0000-0001-8479-0262"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Henning Hermjakob","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","National Center for Protein Sciences, Beijing, China"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"National Center for Protein Sciences, Beijing, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074201106","display_name":"Peter D\u2019Eustachio","orcid":"https://orcid.org/0000-0002-5494-626X"},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter D\u2019Eustachio","raw_affiliation_strings":["NYU School of Medicine, New York, NY 10016, USA"],"affiliations":[{"raw_affiliation_string":"NYU School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":23,"corresponding_author_ids":["https://openalex.org/A5006718188","https://openalex.org/A5052076713","https://openalex.org/A5066783652","https://openalex.org/A5074201106"],"corresponding_institution_ids":["https://openalex.org/I112260969","https://openalex.org/I1303153112","https://openalex.org/I165690674","https://openalex.org/I185261750","https://openalex.org/I57206974"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":125.8177,"has_fulltext":false,"cited_by_count":2342,"citation_normalized_percentile":{"value":0.99988159,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/upload","display_name":"Upload","score":0.6932973265647888},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.6518244743347168},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6262964606285095},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.5490447282791138},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5155398845672607},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4852278232574463},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3932141363620758},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33272361755371094},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.23715642094612122},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.22705501317977905}],"concepts":[{"id":"https://openalex.org/C71901391","wikidata":"https://www.wikidata.org/wiki/Q7126699","display_name":"Upload","level":2,"score":0.6932973265647888},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.6518244743347168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6262964606285095},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.5490447282791138},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5155398845672607},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4852278232574463},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3932141363620758},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33272361755371094},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.23715642094612122},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.22705501317977905}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/nar/gkz1031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz1031","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkz1031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz1031","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7099999785423279,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1068320709","display_name":null,"funder_award_id":"U54GM114833","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5357262175","display_name":null,"funder_award_id":"U41HG003751","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320313288","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1935434993","https://openalex.org/W1989277387","https://openalex.org/W2124045889","https://openalex.org/W2767088268","https://openalex.org/W2771328536","https://openalex.org/W2895689867","https://openalex.org/W2897805491","https://openalex.org/W2900044275","https://openalex.org/W2950595506","https://openalex.org/W4233698560"],"related_works":["https://openalex.org/W2361861616","https://openalex.org/W2263699433","https://openalex.org/W2377979023","https://openalex.org/W2218034408","https://openalex.org/W2392921965","https://openalex.org/W2944823289","https://openalex.org/W2358755282","https://openalex.org/W3037018281","https://openalex.org/W2003209439","https://openalex.org/W4321854979"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"Reactome":[2,40,133],"Knowledgebase":[3],"(https://reactome.org)":[4],"provides":[5],"molecular":[6,24],"details":[7],"of":[8,23,35,46,123,148,163,181,190],"signal":[9],"transduction,":[10],"transport,":[11],"DNA":[12],"replication,":[13],"metabolism":[14],"and":[15,49,87,113,126,138,174,177],"other":[16],"cellular":[17],"processes":[18,48],"as":[19,43,50,60],"an":[20,32,44],"ordered":[21],"network":[22],"transformations":[25],"in":[26,57],"a":[27,36,51,83,154,178],"single":[28],"consistent":[29],"data":[30,58],"model,":[31],"extended":[33],"version":[34],"classic":[37],"metabolic":[38],"map.":[39],"functions":[41],"both":[42],"archive":[45],"biological":[47],"tool":[52,156],"for":[53,111,169],"discovering":[54],"functional":[55],"relationships":[56],"such":[59],"gene":[61],"expression":[62],"profiles":[63],"or":[64],"somatic":[65],"mutation":[66],"catalogs":[67],"from":[68],"tumor":[69],"cells.":[70],"To":[71,145],"extend":[72],"our":[73,149,182],"ability":[74],"to":[75,92,96,107,114,132,134,141,157],"annotate":[76,93],"human":[77],"disease":[78],"processes,":[79],"we":[80,151],"have":[81,88,130,152],"implemented":[82,153],"new":[84,109,116,155,179],"drug":[85],"class":[86],"used":[89],"it":[90],"initially":[91],"drugs":[94],"relevant":[95],"cardiovascular":[97],"disease.":[98],"Our":[99],"annotation":[100,112],"model":[101],"depends":[102],"on":[103],"external":[104],"domain":[105],"experts":[106,125],"identify":[108,135],"areas":[110],"review":[115],"content.":[117],"New":[118],"web":[119],"pages":[120],"facilitate":[121,187],"recruitment":[122],"community":[124],"allow":[127],"those":[128],"who":[129],"contributed":[131],"their":[136,142],"contributions":[137],"link":[139],"them":[140],"ORCID":[143],"records.":[144],"improve":[146],"visualization":[147],"content,":[150],"automatically":[158],"lay":[159],"out":[160],"the":[161,171],"components":[162],"individual":[164],"reactions":[165],"with":[166],"multiple":[167],"options":[168],"downloading":[170],"reaction":[172],"diagrams":[173],"associated":[175],"data,":[176],"display":[180],"event":[183],"hierarchy":[184],"that":[185],"will":[186],"visual":[188],"interpretation":[189],"pathway":[191],"analysis":[192],"results.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":204},{"year":2024,"cited_by_count":308},{"year":2023,"cited_by_count":342},{"year":2022,"cited_by_count":604},{"year":2021,"cited_by_count":594},{"year":2020,"cited_by_count":263},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}