{"id":"https://openalex.org/W2898073106","doi":"https://doi.org/10.1093/nar/gky916","title":"KinaMetrix: a web resource to investigate kinase conformations and inhibitor space","display_name":"KinaMetrix: a web resource to investigate kinase conformations and inhibitor space","publication_year":2018,"publication_date":"2018-10-09","ids":{"openalex":"https://openalex.org/W2898073106","doi":"https://doi.org/10.1093/nar/gky916","mag":"2898073106","pmid":"https://pubmed.ncbi.nlm.nih.gov/30321373"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gky916","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky916","pdf_url":"https://academic.oup.com/nar/article-pdf/47/D1/D361/27436482/gky916.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/47/D1/D361/27436482/gky916.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074008129","display_name":"Rayees Rahman","orcid":"https://orcid.org/0000-0002-0248-0680"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rayees Rahman","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn school of Medicine at Mount Sinai, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn school of Medicine at Mount Sinai, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052340671","display_name":"Peter M.U. Ung","orcid":"https://orcid.org/0000-0002-6849-5252"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Man-Un Ung","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn school of Medicine at Mount Sinai, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn school of Medicine at Mount Sinai, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048927341","display_name":"Avner Schlessinger","orcid":"https://orcid.org/0000-0003-4007-7814"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Avner Schlessinger","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn school of Medicine at Mount Sinai, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn school of Medicine at Mount Sinai, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048927341","https://openalex.org/A5074008129"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":4.0608,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.94872754,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"47","issue":"D1","first_page":"D361","last_page":"D366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.6819245219230652},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6445557475090027},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5863713622093201},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.4840952157974243},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.47511181235313416},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.4576382637023926},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.43340903520584106},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.42657655477523804},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.40733247995376587},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3300514221191406},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.17576643824577332}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6819245219230652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6445557475090027},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5863713622093201},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.4840952157974243},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.47511181235313416},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4576382637023926},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.43340903520584106},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.42657655477523804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40733247995376587},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3300514221191406},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17576643824577332}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003662","descriptor_name":"Decision Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003662","descriptor_name":"Decision Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003662","descriptor_name":"Decision Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gky916","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky916","pdf_url":"https://academic.oup.com/nar/article-pdf/47/D1/D361/27436482/gky916.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:30321373","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30321373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:5301913","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6323924","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6323924","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6323924","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gky916","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky916","pdf_url":"https://academic.oup.com/nar/article-pdf/47/D1/D361/27436482/gky916.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G536789129","display_name":null,"funder_award_id":"GM062754","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6156573265","display_name":null,"funder_award_id":"T32GM062754","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2898073106.pdf","grobid_xml":"https://content.openalex.org/works/W2898073106.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1862448690","https://openalex.org/W1975436091","https://openalex.org/W1975875968","https://openalex.org/W2022609682","https://openalex.org/W2052420692","https://openalex.org/W2130479394","https://openalex.org/W2141205833","https://openalex.org/W2152968740","https://openalex.org/W2154319440","https://openalex.org/W2189824412","https://openalex.org/W2556014018","https://openalex.org/W2604632658","https://openalex.org/W2620416363","https://openalex.org/W2744129621","https://openalex.org/W2784561120","https://openalex.org/W2794211762","https://openalex.org/W2806290811","https://openalex.org/W2807567082","https://openalex.org/W2823044499","https://openalex.org/W2950292741","https://openalex.org/W2951478780","https://openalex.org/W2997958114","https://openalex.org/W3007932287","https://openalex.org/W3020863653","https://openalex.org/W6610017368","https://openalex.org/W6875140408"],"related_works":["https://openalex.org/W3204091482","https://openalex.org/W2081601977","https://openalex.org/W2103159791","https://openalex.org/W2119378770","https://openalex.org/W2595628180","https://openalex.org/W2132732580","https://openalex.org/W2253761889","https://openalex.org/W2607853144","https://openalex.org/W4383473016","https://openalex.org/W2528327487"],"abstract_inverted_index":{"Protein":[0,52],"kinases":[1,69,140,176],"are":[2,164],"among":[3],"the":[4,42,51,89],"most":[5],"explored":[6],"protein":[7,47,90,122],"drug":[8],"targets.":[9],"Visualization":[10],"of":[11,44,99,121,133,175],"kinase":[12,48,91,100,112,191,197],"conformations":[13,73],"is":[14],"critical":[15],"for":[16,24,158,172,188],"understanding":[17],"structure-function":[18],"relationship":[19],"in":[20,50,177],"this":[21],"family":[22],"and":[23,171],"developing":[25,195],"chemically":[26],"unique,":[27],"conformation-specific":[28,196],"small":[29,160],"molecule":[30,161],"drugs.":[31],"We":[32,180],"have":[33],"developed":[34],"Kinformation,":[35],"a":[36,82,97,143,156,186],"random":[37],"forest":[38],"classifier":[39],"that":[40,102,141,163],"annotates":[41],"conformation":[43,169],"over":[45],"3500":[46],"structures":[49,125,132],"Data":[53],"Bank.":[54],"Kinformation":[55],"was":[56],"trained":[57],"on":[58],"structural":[59,119,192],"descriptors":[60,120],"derived":[61],"from":[62],"functionally":[63],"important":[64],"motifs":[65],"to":[66,87,109,117,130,138,147,183],"automatically":[67],"categorize":[68],"into":[70],"five":[71],"major":[72],"with":[74,167],"pharmacological":[75],"relevance.":[76],"Here":[77],"we":[78],"present":[79],"KinaMetrix":[80,106,152,182],"(http://KinaMetrix.com),":[81],"web":[83],"resource":[84,187],"enabling":[85,136],"researchers":[86,189],"investigate":[88],"conformational":[92,104,145],"space":[93,146],"as":[94,96,114,116,155,185],"well":[95,115],"subset":[98],"inhibitors":[101],"exhibit":[103],"specificity.":[105],"allows":[107],"users":[108,137],"classify":[110],"uploaded":[111,149],"structures,":[113],"derive":[118],"kinases.":[123],"Uploaded":[124],"can":[126],"then":[127],"be":[128],"compared":[129],"atomic":[131],"other":[134],"kinases,":[135],"identify":[139],"occupy":[142],"similar":[144],"their":[148],"structure.":[150],"Finally,":[151],"also":[153],"serves":[154],"repository":[157],"both":[159],"substructures":[162],"significantly":[165],"associated":[166],"each":[168],"type,":[170],"homology":[173],"models":[174],"inactive":[178],"conformations.":[179],"expect":[181],"serve":[184],"studying":[190],"biology":[193],"or":[194],"inhibitors.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
