{"id":"https://openalex.org/W4255677297","doi":"https://doi.org/10.1093/nar/gky473","title":"CASTp 3.0: computed atlas of surface topography of proteins","display_name":"CASTp 3.0: computed atlas of surface topography of proteins","publication_year":2018,"publication_date":"2018-05-18","ids":{"openalex":"https://openalex.org/W4255677297","doi":"https://doi.org/10.1093/nar/gky473"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gky473","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky473","pdf_url":"https://academic.oup.com/nar/article-pdf/46/W1/W363/25110551/gky473.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/46/W1/W363/25110551/gky473.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091510674","display_name":"Wei Tian","orcid":"https://orcid.org/0000-0002-2146-1717"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Tian","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449491","display_name":"Chang Chen","orcid":"https://orcid.org/0000-0002-9988-930X"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang Chen","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008164273","display_name":"Xue Lei","orcid":"https://orcid.org/0000-0001-9647-3782"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Lei","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014903716","display_name":"Jieling Zhao","orcid":"https://orcid.org/0000-0002-9801-2434"},"institutions":[{"id":"https://openalex.org/I4210115519","display_name":"Centre de Recherche en Informatique","ror":"https://ror.org/020cdve92","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210091621","https://openalex.org/I4210115519","https://openalex.org/I70768539"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jieling Zhao","raw_affiliation_strings":["Institut National de Recherche en Informatique et en Automatique, Paris\u00a075012,\u00a0France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de Recherche en Informatique et en Automatique, Paris\u00a075012,\u00a0France","institution_ids":["https://openalex.org/I4210115519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091558783","display_name":"Jie Liang","orcid":"https://orcid.org/0000-0002-2773-6427"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Liang","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091558783"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":63.1583,"has_fulltext":true,"cited_by_count":2395,"citation_normalized_percentile":{"value":0.99979041,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"46","issue":"W1","first_page":"W363","last_page":"W367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.965399980545044,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atlas","display_name":"Atlas (anatomy)","score":0.72602778673172},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.7181050777435303},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6770473122596741},{"id":"https://openalex.org/keywords/protein-data-bank","display_name":"Protein Data Bank","score":0.576309084892273},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.5113491415977478},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48364031314849854},{"id":"https://openalex.org/keywords/surface","display_name":"Surface (topology)","score":0.47849148511886597},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4445986747741699},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3566545248031616},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32450443506240845},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.2173534333705902},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.19884192943572998},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.1876368522644043},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.165347158908844},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.14554911851882935},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09431302547454834},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0736171305179596}],"concepts":[{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.72602778673172},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.7181050777435303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6770473122596741},{"id":"https://openalex.org/C119145174","wikidata":"https://www.wikidata.org/wiki/Q7251429","display_name":"Protein Data Bank","level":3,"score":0.576309084892273},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.5113491415977478},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48364031314849854},{"id":"https://openalex.org/C2776799497","wikidata":"https://www.wikidata.org/wiki/Q484298","display_name":"Surface (topology)","level":2,"score":0.47849148511886597},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4445986747741699},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3566545248031616},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32450443506240845},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.2173534333705902},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.19884192943572998},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.1876368522644043},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.165347158908844},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14554911851882935},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09431302547454834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0736171305179596}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gky473","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky473","pdf_url":"https://academic.oup.com/nar/article-pdf/46/W1/W363/25110551/gky473.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4991347","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6031066","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/10958912","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/CASTp_3_0_Computed_Atlas_of_Surface_Topography_of_proteins/10958912","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gky473","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky473","pdf_url":"https://academic.oup.com/nar/article-pdf/46/W1/W363/25110551/gky473.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4019814538","display_name":null,"funder_award_id":"R01 CA204962","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G635212062","display_name":null,"funder_award_id":"R01CA204962","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4255677297.pdf","grobid_xml":"https://content.openalex.org/works/W4255677297.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1762617857","https://openalex.org/W1972159725","https://openalex.org/W1987619816","https://openalex.org/W1997461927","https://openalex.org/W2004360551","https://openalex.org/W2008708467","https://openalex.org/W2013808181","https://openalex.org/W2046643229","https://openalex.org/W2067907944","https://openalex.org/W2073587387","https://openalex.org/W2077776336","https://openalex.org/W2078290150","https://openalex.org/W2105902442","https://openalex.org/W2107723121","https://openalex.org/W2108508060","https://openalex.org/W2111255040","https://openalex.org/W2132629607","https://openalex.org/W2139942857","https://openalex.org/W2140047797","https://openalex.org/W2149432763","https://openalex.org/W2160848247","https://openalex.org/W2170463736","https://openalex.org/W2213686223","https://openalex.org/W2257487078","https://openalex.org/W2537943443","https://openalex.org/W2563411735","https://openalex.org/W2613541742","https://openalex.org/W2766010153","https://openalex.org/W2770278477","https://openalex.org/W2796560163","https://openalex.org/W4210702584","https://openalex.org/W4237978388","https://openalex.org/W6750239088"],"related_works":["https://openalex.org/W2572080171","https://openalex.org/W2058809752","https://openalex.org/W2013211627","https://openalex.org/W3126783617","https://openalex.org/W2615841538","https://openalex.org/W2113897954","https://openalex.org/W3093468851","https://openalex.org/W4280624450","https://openalex.org/W1897312405","https://openalex.org/W2145118195"],"abstract_inverted_index":{"Geometric":[0],"and":[1,12,45,49,85,88,107,126,128,133,145],"topological":[2,50],"properties":[3,51],"of":[4,16,28,31,52,73,90,100,104,112,123,138,148],"protein":[5,53,91,124,149],"structures,":[6],"including":[7,136],"surface":[8],"pockets,":[9,105,127],"interior":[10],"cavities":[11,106],"cross":[13],"channels,":[14,108],"are":[15],"fundamental":[17],"importance":[18],"for":[19,42],"proteins":[20,32],"to":[21,82],"carry":[22],"out":[23],"their":[24],"functions.":[25],"Computed":[26],"Atlas":[27],"Surface":[29],"Topography":[30],"(CASTp)":[33],"is":[34,156],"a":[35],"web":[36,75,154],"server":[37,155],"that":[38],"provides":[39],"online":[40],"services":[41],"locating,":[43],"delineating":[44],"measuring":[46],"these":[47],"geometric":[48],"structures.":[54],"It":[55],"has":[56],"been":[57],"widely":[58],"used":[59],"since":[60],"its":[61],"inception":[62],"in":[63,115],"2003.":[64],"In":[65,93],"this":[66],"article,":[67],"we":[68],"present":[69],"the":[70,74,101,116],"latest":[71],"version":[72],"server,":[76],"CASTp":[77,79,152],"3.0.":[78],"3.0":[80,153],"continues":[81],"provide":[83],"reliable":[84],"comprehensive":[86],"identifications":[87],"quantifications":[89],"topography.":[92],"addition,":[94],"it":[95],"now":[96],"provides:":[97],"(i)":[98],"imprints":[99],"negative":[102],"volumes":[103],"(ii)":[109],"topographic":[110],"features":[111],"biological":[113],"assemblies":[114],"Protein":[117],"Data":[118],"Bank,":[119],"(iii)":[120],"improved":[121],"visualization":[122],"structures":[125],"(iv)":[129],"more":[130],"intuitive":[131],"structural":[132],"annotated":[134],"information,":[135],"information":[137],"secondary":[139],"structure,":[140],"functional":[141],"sites,":[142],"variant":[143],"sites":[144],"other":[146],"annotations":[147],"residues.":[150],"The":[151],"freely":[157],"accessible":[158],"at":[159],"http://sts.bioe.uic.edu/castp/.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":146},{"year":2025,"cited_by_count":383},{"year":2024,"cited_by_count":433},{"year":2023,"cited_by_count":408},{"year":2022,"cited_by_count":384},{"year":2021,"cited_by_count":309},{"year":2020,"cited_by_count":223},{"year":2019,"cited_by_count":96},{"year":2018,"cited_by_count":10},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}