{"id":"https://openalex.org/W2802689071","doi":"https://doi.org/10.1093/nar/gky349","title":"geno2pheno[ngs-freq]: a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data","display_name":"geno2pheno[ngs-freq]: a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data","publication_year":2018,"publication_date":"2018-04-24","ids":{"openalex":"https://openalex.org/W2802689071","doi":"https://doi.org/10.1093/nar/gky349","mag":"2802689071","pmid":"https://pubmed.ncbi.nlm.nih.gov/29718426"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gky349","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky349","pdf_url":"https://academic.oup.com/nar/article-pdf/46/W1/W271/25110528/gky349.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/46/W1/W271/25110528/gky349.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029671584","display_name":"Matthias D\u00f6ring","orcid":"https://orcid.org/0000-0002-4261-9210"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias D\u00f6ring","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040881881","display_name":"Joachim B\u00fcch","orcid":"https://orcid.org/0000-0003-3534-9512"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim B\u00fcch","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003113468","display_name":"Georg Friedrich","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg Friedrich","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085913224","display_name":"Alejandro Pironti","orcid":"https://orcid.org/0000-0002-7759-6776"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alejandro Pironti","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001373612","display_name":"Prabhav Kalaghatgi","orcid":"https://orcid.org/0000-0002-4742-6928"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Prabhav Kalaghatgi","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023401610","display_name":"Elena Knops","orcid":"https://orcid.org/0000-0001-7398-3026"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena Knops","raw_affiliation_strings":["Institute of Virology, University of Cologne, F\u00fcrst-P\u00fcckler-Str. 56, 50935 Cologne, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, F\u00fcrst-P\u00fcckler-Str. 56, 50935 Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030672602","display_name":"Eva Heger","orcid":"https://orcid.org/0000-0001-7625-5139"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva Heger","raw_affiliation_strings":["Institute of Virology, University of Cologne, F\u00fcrst-P\u00fcckler-Str. 56, 50935 Cologne, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, F\u00fcrst-P\u00fcckler-Str. 56, 50935 Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051477244","display_name":"Martin Obermeier","orcid":"https://orcid.org/0000-0003-2511-9553"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Obermeier","raw_affiliation_strings":["MVZ Medizinisches Infektiologiezentrum Berlin (MIB), Oudenarder Str. 16, 13353 Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"MVZ Medizinisches Infektiologiezentrum Berlin (MIB), Oudenarder Str. 16, 13353 Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000627402","display_name":"Martin D\u00e4umer","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin D\u00e4umer","raw_affiliation_strings":["Seq-IT, Pfaffpl. 10, 67655 Kaiserslautern, Germany"],"affiliations":[{"raw_affiliation_string":"Seq-IT, Pfaffpl. 10, 67655 Kaiserslautern, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113464787","display_name":"Alexander Thielen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Thielen","raw_affiliation_strings":["Seq-IT, Pfaffpl. 10, 67655 Kaiserslautern, Germany"],"affiliations":[{"raw_affiliation_string":"Seq-IT, Pfaffpl. 10, 67655 Kaiserslautern, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074420045","display_name":"Rolf Kaiser","orcid":"https://orcid.org/0000-0002-2640-2548"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Kaiser","raw_affiliation_strings":["Institute of Virology, University of Cologne, F\u00fcrst-P\u00fcckler-Str. 56, 50935 Cologne, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, F\u00fcrst-P\u00fcckler-Str. 56, 50935 Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556977","display_name":"Thomas Lengauer","orcid":"https://orcid.org/0000-0003-3801-2640"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Lengauer","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076705834","display_name":"Nico Pfeifer","orcid":"https://orcid.org/0000-0002-4647-8566"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nico Pfeifer","raw_affiliation_strings":["Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","Medical Faculty, University of T\u00fcbingen, Geissweg 5, 72076 T\u00fcbingen, Germany","Methods in Medical Informatics, Department of Computer Science, University of T\u00fcbingen, Sand 14, 72076 T\u00fcbingen, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Medical Faculty, University of T\u00fcbingen, Geissweg 5, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Methods in Medical Informatics, Department of Computer Science, University of T\u00fcbingen, Sand 14, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5029671584"],"corresponding_institution_ids":["https://openalex.org/I4210109712"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":4.0459,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.9485391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"46","issue":"W1","first_page":"W271","last_page":"W277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8735828399658203},{"id":"https://openalex.org/keywords/sanger-sequencing","display_name":"Sanger sequencing","score":0.5692721009254456},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5141994953155518},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5005500316619873},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4790726602077484},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4727029800415039},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.47006756067276},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4239037334918976},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.41089779138565063},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.22079282999038696},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19618520140647888}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8735828399658203},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.5692721009254456},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5141994953155518},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5005500316619873},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4790726602077484},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4727029800415039},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.47006756067276},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4239037334918976},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.41089779138565063},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22079282999038696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19618520140647888}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gky349","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky349","pdf_url":"https://academic.oup.com/nar/article-pdf/46/W1/W271/25110528/gky349.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:29718426","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29718426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:escidoc.org:escidoc:2585250","is_oa":true,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0001-3F53-C","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:4991310","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6031006","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gky349","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gky349","pdf_url":"https://academic.oup.com/nar/article-pdf/46/W1/W271/25110528/gky349.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2802689071.pdf","grobid_xml":"https://content.openalex.org/works/W2802689071.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W14725960","https://openalex.org/W95648324","https://openalex.org/W136096659","https://openalex.org/W1966063036","https://openalex.org/W1977852362","https://openalex.org/W1978023671","https://openalex.org/W1978173716","https://openalex.org/W1984898374","https://openalex.org/W1988215875","https://openalex.org/W2009467617","https://openalex.org/W2021420302","https://openalex.org/W2024585092","https://openalex.org/W2027969303","https://openalex.org/W2030017358","https://openalex.org/W2032847961","https://openalex.org/W2033413903","https://openalex.org/W2042148102","https://openalex.org/W2044864734","https://openalex.org/W2045562270","https://openalex.org/W2047516879","https://openalex.org/W2063159959","https://openalex.org/W2063880708","https://openalex.org/W2066480278","https://openalex.org/W2079913459","https://openalex.org/W2084273391","https://openalex.org/W2096504879","https://openalex.org/W2103576282","https://openalex.org/W2105712999","https://openalex.org/W2113136559","https://openalex.org/W2119284644","https://openalex.org/W2124309574","https://openalex.org/W2143898770","https://openalex.org/W2158013170","https://openalex.org/W2158875278","https://openalex.org/W2227151527","https://openalex.org/W2318156787","https://openalex.org/W2397427953","https://openalex.org/W2509030308","https://openalex.org/W2524622036","https://openalex.org/W2541643513","https://openalex.org/W2553990959","https://openalex.org/W2567518065","https://openalex.org/W2575880746","https://openalex.org/W2606694963","https://openalex.org/W2743239314","https://openalex.org/W2755317519","https://openalex.org/W4230982365","https://openalex.org/W4236190976","https://openalex.org/W6603940800","https://openalex.org/W6605527094","https://openalex.org/W6743726815"],"related_works":["https://openalex.org/W2805859037","https://openalex.org/W2403609377","https://openalex.org/W2041048994","https://openalex.org/W4313342334","https://openalex.org/W4225751448","https://openalex.org/W4313584754","https://openalex.org/W2276490703","https://openalex.org/W3107980954","https://openalex.org/W3134891899","https://openalex.org/W3210327416"],"abstract_inverted_index":{"Identifying":[0],"resistance":[1,38,45,62,87,165,187],"to":[2,30,68,160,185],"antiretroviral":[3],"drugs":[4],"is":[5,119,166,195],"crucial":[6],"for":[7,60,83,132],"ensuring":[8],"the":[9,100,111,141,158,169],"successful":[10],"treatment":[11],"of":[12,103,114,135,163,172],"patients":[13],"infected":[14],"with":[15,191],"viruses":[16],"such":[17,139],"as":[18],"human":[19],"immunodeficiency":[20],"virus":[21,26],"(HIV)":[22],"or":[23,105],"hepatitis":[24],"C":[25],"(HCV).":[27],"In":[28],"contrast":[29],"Sanger":[31],"sequencing,":[32],"next-generation":[33],"sequencing":[34],"(NGS)":[35],"can":[36,51,177],"detect":[37],"mutations":[39],"in":[40,63,88,188],"minority":[41],"populations.":[42],"Thus,":[43],"genotypic":[44],"testing":[46],"based":[47],"on":[48,95],"NGS":[49,64,117],"data":[50,118],"offer":[52],"novel,":[53],"treatment-relevant":[54],"insights.":[55],"Since":[56],"existing":[57],"web":[58,81],"services":[59],"analyzing":[61],"samples":[65],"are":[66,130],"subject":[67],"long":[69],"processing":[70,115],"times":[71],"and":[72,90,174,194],"follow":[73],"strictly":[74],"rules-based":[75],"approaches,":[76],"we":[77],"developed":[78],"geno2pheno[ngs-freq],":[79],"a":[80,108,122,133,152,161],"service":[82],"rapidly":[84],"identifying":[85],"drug":[86],"HIV-1":[89],"HCV":[91],"samples.":[92],"By":[93],"relying":[94],"frequency":[96,123],"files":[97],"that":[98,140],"provide":[99],"read":[101],"counts":[102],"nucleotides":[104,147],"codons":[106],"along":[107],"viral":[109,189],"genome,":[110],"time-intensive":[112],"step":[113],"raw":[116],"eliminated.":[120],"Once":[121],"file":[124],"has":[125],"been":[126],"uploaded,":[127],"consensus":[128],"sequences":[129,143,159],"generated":[131],"set":[134,162],"user-defined":[136],"prevalence":[137,150],"cutoffs,":[138],"constructed":[142],"contain":[144],"only":[145],"those":[146],"whose":[148],"codon":[149],"exceeds":[151],"given":[153],"cutoff.":[154],"After":[155],"locally":[156],"aligning":[157],"references,":[164],"predicted":[167],"using":[168],"well-established":[170],"approaches":[171],"geno2pheno[resistance]":[173],"geno2pheno[hcv].":[175],"geno2pheno[ngs-freq]":[176],"assist":[178],"clinical":[179],"decision":[180],"making":[181],"by":[182],"enabling":[183],"users":[184],"explore":[186],"populations":[190],"different":[192],"abundances":[193],"freely":[196],"available":[197],"at":[198],"http://ngs.geno2pheno.org.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}