{"id":"https://openalex.org/W2619954869","doi":"https://doi.org/10.1093/nar/gkx462","title":"LimTox: a web tool for applied text mining of adverse event and toxicity associations of compounds, drugs and genes","display_name":"LimTox: a web tool for applied text mining of adverse event and toxicity associations of compounds, drugs and genes","publication_year":2017,"publication_date":"2017-05-16","ids":{"openalex":"https://openalex.org/W2619954869","doi":"https://doi.org/10.1093/nar/gkx462","mag":"2619954869","pmid":"https://pubmed.ncbi.nlm.nih.gov/28531339"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkx462","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx462","pdf_url":"https://academic.oup.com/nar/article-pdf/45/W1/W484/18137692/gkx462.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/45/W1/W484/18137692/gkx462.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042050722","display_name":"Andr\u00e9s Ca\u00f1ada","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andres Ca\u00f1ada","raw_affiliation_strings":["Spanish National Bioinformatics Institute Unit, Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spanish National Bioinformatics Institute Unit, Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059757648","display_name":"Salvador Capella-Guti\u00e9rrez","orcid":"https://orcid.org/0000-0002-0309-604X"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Salvador Capella-Gutierrez","raw_affiliation_strings":["Spanish National Bioinformatics Institute Unit, Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0309-604X","affiliations":[{"raw_affiliation_string":"Spanish National Bioinformatics Institute Unit, Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027971106","display_name":"Obdulia Rabal","orcid":"https://orcid.org/0000-0002-3224-0987"},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Obdulia Rabal","raw_affiliation_strings":["Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081476843","display_name":"Julen Oyarz\u00e1bal","orcid":"https://orcid.org/0000-0003-1941-7255"},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julen Oyarzabal","raw_affiliation_strings":["Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015217651","display_name":"Alfonso Valencia","orcid":"https://orcid.org/0000-0002-8937-6789"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I2799803557","display_name":"Barcelona Supercomputing Center","ror":"https://ror.org/05sd8tv96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2799803557","https://openalex.org/I9617848"]},{"id":"https://openalex.org/I4210122345","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/01z1gye03","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122345","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alfonso Valencia","raw_affiliation_strings":["Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC-CRG-IRB, Barcelona 08028, Spain","Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), 08010 Barcelona, Spain","Life Science Department, Barcelona Supercomputing Centre (BSC-CNS), 08034 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB, Research Program in Computational Biology, BSC-CRG-IRB, Barcelona 08028, Spain","institution_ids":["https://openalex.org/I2799803557","https://openalex.org/I4210122345","https://openalex.org/I9617848"]},{"raw_affiliation_string":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), 08010 Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Life Science Department, Barcelona Supercomputing Centre (BSC-CNS), 08034 Barcelona, Spain","institution_ids":["https://openalex.org/I2799803557","https://openalex.org/I9617848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007203127","display_name":"Martin Krallinger","orcid":"https://orcid.org/0000-0002-2646-8782"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Martin Krallinger","raw_affiliation_strings":["Biological Text Mining Unit, Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Text Mining Unit, Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain","institution_ids":["https://openalex.org/I4210089594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007203127"],"corresponding_institution_ids":["https://openalex.org/I4210089594"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":2.0268,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.87131122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"45","issue":"W1","first_page":"W484","last_page":"W489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9793000221252441,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipidosis","display_name":"Phospholipidosis","score":0.6005038619041443},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5027213096618652},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4803401231765747},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.44746196269989014},{"id":"https://openalex.org/keywords/table","display_name":"Table (database)","score":0.44142258167266846},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.42630666494369507},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.418689489364624},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41455650329589844},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.37310993671417236},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.26940783858299255},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1052122414112091}],"concepts":[{"id":"https://openalex.org/C2779934242","wikidata":"https://www.wikidata.org/wiki/Q7187520","display_name":"Phospholipidosis","level":4,"score":0.6005038619041443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5027213096618652},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4803401231765747},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.44746196269989014},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.44142258167266846},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42630666494369507},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.418689489364624},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41455650329589844},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.37310993671417236},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.26940783858299255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1052122414112091},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gkx462","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx462","pdf_url":"https://academic.oup.com/nar/article-pdf/45/W1/W484/18137692/gkx462.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:28531339","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28531339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:repositori-api.upf.edu:10230/35008","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/35008","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:recercat.cat:2072/290928","is_oa":true,"landing_page_url":"http://hdl.handle.net/2117/106762","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:upcommons.upc.edu:2117/106762","is_oa":false,"landing_page_url":"https://hdl.handle.net/2117/106762","pdf_url":null,"source":{"id":"https://openalex.org/S4377196262","display_name":"UPCommons institutional repository (Universitat Polit\u00e8cnica de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I9617848","host_organization_name":"Universitat Polit\u00e8cnica de Catalunya","host_organization_lineage":["https://openalex.org/I9617848"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dnet:repisalud___::787065a9ceee8368cc25b3cbbf17c791","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12105/7101","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5570141","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5570141","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkx462","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx462","pdf_url":"https://academic.oup.com/nar/article-pdf/45/W1/W484/18137692/gkx462.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2628364946","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G4108925770","display_name":"Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities","funder_award_id":"115002","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4937468798","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5830402311","display_name":null,"funder_award_id":"PT13/0001","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G7244523127","display_name":null,"funder_award_id":"PT13/0001","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7287202624","display_name":"Open Mining INfrastructure for TExt and Data","funder_award_id":"654021","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G81988884","display_name":null,"funder_award_id":"654021","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G8646936266","display_name":null,"funder_award_id":"115002","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8824911526","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2619954869.pdf","grobid_xml":"https://content.openalex.org/works/W2619954869.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1831214161","https://openalex.org/W1976316416","https://openalex.org/W1994306321","https://openalex.org/W2040610660","https://openalex.org/W2085860988","https://openalex.org/W2087561463","https://openalex.org/W2090773565","https://openalex.org/W2101553882","https://openalex.org/W2117349377","https://openalex.org/W2124001239","https://openalex.org/W2129767020","https://openalex.org/W2134956122","https://openalex.org/W2135505477","https://openalex.org/W2138275182","https://openalex.org/W2153138487","https://openalex.org/W2516150684","https://openalex.org/W2915806464"],"related_works":["https://openalex.org/W2147123014","https://openalex.org/W1986702471","https://openalex.org/W2907020574","https://openalex.org/W2159521451","https://openalex.org/W1827643587","https://openalex.org/W3165666110","https://openalex.org/W2024610445","https://openalex.org/W1970191094","https://openalex.org/W2077732560","https://openalex.org/W2156160866"],"abstract_inverted_index":{"A":[0],"considerable":[1],"effort":[2],"has":[3],"been":[4],"devoted":[5],"to":[6,172],"retrieve":[7],"systematically":[8],"information":[9,83],"for":[10,57,128],"genes":[11,148],"and":[12,26,34,82,92,107,137,161,170,175],"proteins":[13],"as":[14,16,28],"well":[15],"relationships":[17],"between":[18],"them.":[19],"Despite":[20],"the":[21,113],"importance":[22],"of":[23,41,76,103,116],"chemical":[24,44,146],"compounds":[25],"drugs":[27],"a":[29,38,59,74,101],"central":[30],"bio-entity":[31],"in":[32,155],"pharmacological":[33],"biological":[35],"research,":[36],"only":[37],"limited":[39],"number":[40],"freely":[42],"available":[43],"text-mining/search":[45],"engine":[46],"technologies":[47],"are":[48],"currently":[49],"accessible.":[50],"Here":[51],"we":[52],"present":[53],"LimTox":[54,86,117,166,181],"(Literature":[55],"Mining":[56],"Toxicology),":[58],"web-based":[60],"online":[61],"biomedical":[62],"search":[63,143],"tool":[64,140],"with":[65],"special":[66],"focus":[67,115],"on":[68,88,119,152],"adverse":[69,120],"hepatobiliary":[70],"reactions.":[71],"It":[72],"integrates":[73],"range":[75],"text":[77,105],"mining,":[78],"named":[79],"entity":[80],"recognition":[81],"extraction":[84],"components.":[85],"relies":[87],"machine-learning,":[89],"rule-based,":[90],"pattern-based":[91],"term":[93],"lookup":[94],"strategies.":[95],"This":[96,139],"system":[97],"processes":[98],"scientific":[99],"abstracts,":[100],"set":[102],"full":[104],"articles":[106],"medical":[108],"agency":[109],"assessment":[110],"reports.":[111],"Although":[112],"main":[114],"is":[118,168,177],"liver":[121,163],"events,":[122],"it":[123],"enables":[124],"also":[125],"basic":[126],"searches":[127],"other":[129],"organ":[130],"level":[131],"toxicity":[132],"associations":[133],"(nephrotoxicity,":[134],"cardiotoxicity,":[135],"thyrotoxicity":[136],"phospholipidosis).":[138],"supports":[141],"specialized":[142],"queries":[144],"for:":[145],"compounds/drugs,":[147],"(with":[149],"additional":[150],"emphasis":[151],"key":[153],"enzymes":[154],"drug":[156],"metabolism,":[157],"namely":[158],"P450":[159],"cytochromes-CYPs)":[160],"biochemical":[162],"markers.":[164],"The":[165],"website":[167],"free":[169],"open":[171],"all":[173],"users":[174],"there":[176],"no":[178],"login":[179],"requirement.":[180],"can":[182],"be":[183],"accessed":[184],"at:":[185],"http://limtox.bioinfo.cnio.es.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}