{"id":"https://openalex.org/W2611175157","doi":"https://doi.org/10.1093/nar/gkx336","title":"BIS2Analyzer: a server for co-evolution analysis of conserved protein families","display_name":"BIS2Analyzer: a server for co-evolution analysis of conserved protein families","publication_year":2017,"publication_date":"2017-04-20","ids":{"openalex":"https://openalex.org/W2611175157","doi":"https://doi.org/10.1093/nar/gkx336","mag":"2611175157","pmid":"https://pubmed.ncbi.nlm.nih.gov/28472458"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkx336","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx336","pdf_url":"https://academic.oup.com/nar/article-pdf/45/W1/W307/18137361/gkx336.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/45/W1/W307/18137361/gkx336.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048942980","display_name":"Francesco Oteri","orcid":"https://orcid.org/0000-0002-4284-3597"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097156","display_name":"Biologie Computationnelle, Quantitative et Synth\u00e9tique","ror":"https://ror.org/00pcqj134","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210097156"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Francesco Oteri","raw_affiliation_strings":["Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097156","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)","institution_ids":["https://openalex.org/I4210097156","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090189197","display_name":"Francesca Nadalin","orcid":"https://orcid.org/0000-0002-3886-0896"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097156","display_name":"Biologie Computationnelle, Quantitative et Synth\u00e9tique","ror":"https://ror.org/00pcqj134","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210097156"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Francesca Nadalin","raw_affiliation_strings":["Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097156","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)","institution_ids":["https://openalex.org/I4210097156","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044767772","display_name":"Rapha\u00ebl Champeimont","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097156","display_name":"Biologie Computationnelle, Quantitative et Synth\u00e9tique","ror":"https://ror.org/00pcqj134","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210097156"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rapha\u00ebl Champeimont","raw_affiliation_strings":["Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097156","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)","institution_ids":["https://openalex.org/I4210097156","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038174177","display_name":"Alessandra Carbone","orcid":"https://orcid.org/0000-0003-2098-5743"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I185839726","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266","country_code":"FR","type":"education","lineage":["https://openalex.org/I185839726"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097156","display_name":"Biologie Computationnelle, Quantitative et Synth\u00e9tique","ror":"https://ror.org/00pcqj134","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210097156"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Alessandra Carbone","raw_affiliation_strings":["Institut Universitaire de France, 75005 Paris, France","Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","IUF - Institut Universitaire de France (Maison des Universit\u00e9s 103 Boulevard Saint-Michel 75005 Paris - France)","LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Universitaire de France, 75005 Paris, France","institution_ids":["https://openalex.org/I185839726"]},{"raw_affiliation_string":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097156","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"IUF - Institut Universitaire de France (Maison des Universit\u00e9s 103 Boulevard Saint-Michel 75005 Paris - France)","institution_ids":["https://openalex.org/I185839726"]},{"raw_affiliation_string":"LCQB - Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (Biologie Computationnelle et Quantitative UMR 7238 CNRS-Universit\u00e9 Pierre et Marie Curie Site des Cordeliers B\u00e2t. A - 4\u00e8me \u00e9tage, 15, Rue de l'Ecole de M\u00e9decine 75006 Paris, France - France)","institution_ids":["https://openalex.org/I4210097156","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038174177","https://openalex.org/A5048942980","https://openalex.org/A5090189197"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I185839726","https://openalex.org/I39804081","https://openalex.org/I4210097156"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":2130,"currency":"EUR","value_usd":2297},"fwci":2.295,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.88740928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"45","issue":"W1","first_page":"W307","last_page":"W314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9077491760253906},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.542277455329895},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.5338011980056763},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5251585841178894},{"id":"https://openalex.org/keywords/protein-family","display_name":"Protein family","score":0.47603657841682434},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.4718456268310547},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.4657234847545624},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.45811620354652405},{"id":"https://openalex.org/keywords/molecular-evolution","display_name":"Molecular evolution","score":0.45724913477897644},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.4565827250480652},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4382641315460205},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4356032609939575},{"id":"https://openalex.org/keywords/evolutionary-dynamics","display_name":"Evolutionary dynamics","score":0.43382522463798523},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42989516258239746},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.42100751399993896},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.34834763407707214},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.16424870491027832},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15052226185798645},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.09389632940292358}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9077491760253906},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.542277455329895},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.5338011980056763},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5251585841178894},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.47603657841682434},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4718456268310547},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.4657234847545624},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.45811620354652405},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.45724913477897644},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4565827250480652},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4382641315460205},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4356032609939575},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.43382522463798523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42989516258239746},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.42100751399993896},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.34834763407707214},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.16424870491027832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15052226185798645},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09389632940292358},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058767","descriptor_name":"Protein Unfolding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058767","descriptor_name":"Protein Unfolding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058767","descriptor_name":"Protein Unfolding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkx336","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx336","pdf_url":"https://academic.oup.com/nar/article-pdf/45/W1/W307/18137361/gkx336.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:28472458","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28472458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5570204","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5570204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01520493v1","is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-01520493","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Research, 2017, pp.W307-W314. &#x27E8;10.1093/nar/gkx336&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkx336","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx336","pdf_url":"https://academic.oup.com/nar/article-pdf/45/W1/W307/18137361/gkx336.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3183336939","display_name":"Vers une cartographie haute r\u00e9solution des interactions prot\u00e9iques \u00e0 l\u2019\u00e9chelle du g\u00e9nome.","funder_award_id":"ANR-11-BINF-0003","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2611175157.pdf","grobid_xml":"https://content.openalex.org/works/W2611175157.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1514031343","https://openalex.org/W1748819278","https://openalex.org/W1904722109","https://openalex.org/W1982874561","https://openalex.org/W1984845477","https://openalex.org/W1995480317","https://openalex.org/W1996835973","https://openalex.org/W2002412353","https://openalex.org/W2008545402","https://openalex.org/W2009123297","https://openalex.org/W2013425283","https://openalex.org/W2014290325","https://openalex.org/W2017519756","https://openalex.org/W2021164408","https://openalex.org/W2028415754","https://openalex.org/W2044100153","https://openalex.org/W2048454141","https://openalex.org/W2051545676","https://openalex.org/W2060259161","https://openalex.org/W2061042699","https://openalex.org/W2065921821","https://openalex.org/W2085036090","https://openalex.org/W2092006899","https://openalex.org/W2098484839","https://openalex.org/W2108401821","https://openalex.org/W2108486693","https://openalex.org/W2111211467","https://openalex.org/W2115315232","https://openalex.org/W2120836664","https://openalex.org/W2137566700","https://openalex.org/W2149531726","https://openalex.org/W2153125965","https://openalex.org/W2166701319","https://openalex.org/W2167114132","https://openalex.org/W2169478909","https://openalex.org/W2224298134","https://openalex.org/W2301217054","https://openalex.org/W2402425474","https://openalex.org/W2949867299","https://openalex.org/W3199943451"],"related_works":["https://openalex.org/W2021438430","https://openalex.org/W4232322043","https://openalex.org/W2275032899","https://openalex.org/W3045823453","https://openalex.org/W2121560377","https://openalex.org/W2075451741","https://openalex.org/W2139240863","https://openalex.org/W2053803793","https://openalex.org/W2070693796","https://openalex.org/W2128772387"],"abstract_inverted_index":{"Along":[0],"protein":[1,75,111,119],"sequences,":[2],"co-evolution":[3,142],"analysis":[4,105,143],"identifies":[5],"residue":[6],"pairs":[7,109],"demonstrating":[8],"either":[9],"a":[10,30,44,99,124,136,151],"specific":[11,32],"co-adaptation,":[12],"where":[13],"changes":[14,23],"in":[15,24,43,87,110,146],"one":[16],"of":[17,40,51,64,74,80,106,127,140,161],"the":[18,25,37,52,72,78,103,141,162],"residues":[19,42],"are":[20],"compensated":[21],"by":[22],"other":[26],"during":[27],"evolution":[28],"or":[29,58],"less":[31],"external":[33],"force":[34],"that":[35],"affects":[36],"evolutionary":[38],"rates":[39],"both":[41,48],"similar":[45,129],"magnitude.":[46],"In":[47],"cases,":[49],"independently":[50],"underlying":[53],"cause,":[54],"co-evolutionary":[55],"signatures":[56],"within":[57],"between":[59],"proteins":[60],"serve":[61],"as":[62],"markers":[63],"physical":[65],"interactions":[66],"and/or":[67],"functional":[68],"relationships.":[69],"Depending":[70],"on":[71,134],"type":[73],"under":[76],"study,":[77],"set":[79],"available":[81],"homologous":[82],"sequences":[83],"may":[84],"greatly":[85],"differ":[86],"size":[88],"and":[89,117,153],"amino":[90],"acid":[91],"variability.":[92],"BIS2Analyzer,":[93],"openly":[94],"accessible":[95],"at":[96],"http://www.lcqb.upmc.fr/BIS2Analyzer/,":[97],"is":[98,132],"web":[100],"server":[101],"providing":[102],"online":[104],"co-evolving":[107],"amino-acid":[108],"alignments,":[112],"especially":[113],"designed":[114],"for":[115],"vertebrate":[116],"viral":[118],"families,":[120],"which":[121],"typically":[122],"display":[123],"small":[125],"number":[126],"highly":[128],"sequences.":[130],"It":[131],"based":[133],"BIS2,":[135],"re-implemented":[137],"fast":[138],"version":[139],"tool":[144],"Blocks":[145],"Sequences":[147],"(BIS).":[148],"BIS2Analyzer":[149],"provides":[150],"rich":[152],"interactive":[154],"graphical":[155],"interface":[156],"to":[157],"ease":[158],"biological":[159],"interpretation":[160],"results.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-07T14:30:12.667765","created_date":"2025-10-10T00:00:00"}
