{"id":"https://openalex.org/W2769859791","doi":"https://doi.org/10.1093/nar/gkx1133","title":"mSignatureDB: a database for deciphering mutational signatures in human cancers","display_name":"mSignatureDB: a database for deciphering mutational signatures in human cancers","publication_year":2017,"publication_date":"2017-10-26","ids":{"openalex":"https://openalex.org/W2769859791","doi":"https://doi.org/10.1093/nar/gkx1133","mag":"2769859791","pmid":"https://pubmed.ncbi.nlm.nih.gov/29145625"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkx1133","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx1133","pdf_url":"https://academic.oup.com/nar/article-pdf/46/D1/D964/23162424/gkx1133.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/46/D1/D964/23162424/gkx1133.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080244422","display_name":"Po-Jung Huang","orcid":"https://orcid.org/0000-0002-8728-8881"},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Jung Huang","raw_affiliation_strings":["Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan","Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026846221","display_name":"Ling\u2010Ya Chiu","orcid":"https://orcid.org/0000-0001-8566-7696"},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ling-Ya Chiu","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan"],"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102816014","display_name":"Chi\u2010Ching Lee","orcid":"https://orcid.org/0000-0003-2912-7745"},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Ching Lee","raw_affiliation_strings":["Department and Graduate Institute of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan","Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department and Graduate Institute of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011599641","display_name":"Yuan\u2010Ming Yeh","orcid":"https://orcid.org/0000-0001-8720-947X"},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yuan-Ming Yeh","raw_affiliation_strings":["Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan","Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan"],"affiliations":[{"raw_affiliation_string":"Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970"]},{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040026742","display_name":"Kuo\u2010Yang Huang","orcid":"https://orcid.org/0000-0002-4038-1579"},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Yang Huang","raw_affiliation_strings":["Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111516245","display_name":"Cheng-Hsun Chiu","orcid":null},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Hsun Chiu","raw_affiliation_strings":["Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan","Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan"],"affiliations":[{"raw_affiliation_string":"Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970"]},{"raw_affiliation_string":"Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040425523","display_name":"Ping Tang","orcid":"https://orcid.org/0000-0003-0253-1836"},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Petrus Tang","raw_affiliation_strings":["Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan","Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan"],"affiliations":[{"raw_affiliation_string":"Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970"]},{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5040425523"],"corresponding_institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":4.2705,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95825843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"46","issue":"D1","first_page":"D964","last_page":"D970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7281396985054016},{"id":"https://openalex.org/keywords/cosmic-cancer-database","display_name":"COSMIC cancer database","score":0.6347252726554871},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5616217255592346},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.4480021893978119},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4459277093410492},{"id":"https://openalex.org/keywords/sanger-sequencing","display_name":"Sanger sequencing","score":0.44435518980026245},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35242724418640137},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3435940146446228},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.26196157932281494},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.24098420143127441},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2163940966129303}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7281396985054016},{"id":"https://openalex.org/C59375849","wikidata":"https://www.wikidata.org/wiki/Q5013513","display_name":"COSMIC cancer database","level":2,"score":0.6347252726554871},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5616217255592346},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4480021893978119},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4459277093410492},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.44435518980026245},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35242724418640137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3435940146446228},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26196157932281494},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24098420143127441},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2163940966129303}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkx1133","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx1133","pdf_url":"https://academic.oup.com/nar/article-pdf/46/D1/D964/23162424/gkx1133.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:29145625","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29145625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:4668274","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5753213","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5753213","is_oa":true,"landing_page_url":"http://doi.org/10.1093/nar/gkx1133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkx1133","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkx1133","pdf_url":"https://academic.oup.com/nar/article-pdf/46/D1/D964/23162424/gkx1133.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3365722850","display_name":null,"funder_award_id":"MOST 10","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G3505022365","display_name":null,"funder_award_id":"MOST 104","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5563719332","display_name":null,"funder_award_id":"106-2221-E-","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G7160539585","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G951433114","display_name":null,"funder_award_id":"007-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320323441","display_name":"Chang Gung Memorial Hospital, Linkou","ror":"https://ror.org/02dnn6q67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2769859791.pdf","grobid_xml":"https://content.openalex.org/works/W2769859791.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2008255210","https://openalex.org/W2019690836","https://openalex.org/W2118151336","https://openalex.org/W2123134606","https://openalex.org/W2124977765","https://openalex.org/W2148856719","https://openalex.org/W2149031002","https://openalex.org/W2149441684","https://openalex.org/W2152061559","https://openalex.org/W2276335691","https://openalex.org/W2325219633","https://openalex.org/W2340219588","https://openalex.org/W2918086501"],"related_works":["https://openalex.org/W2322817607","https://openalex.org/W2546271652","https://openalex.org/W2563724974","https://openalex.org/W4296822203","https://openalex.org/W4306843370","https://openalex.org/W2790156482","https://openalex.org/W4386141950","https://openalex.org/W4323566954","https://openalex.org/W3005951787","https://openalex.org/W2773147801"],"abstract_inverted_index":{"Cancer":[0],"is":[1,20,40,97,186],"a":[2,41,113,187],"genetic":[3],"disease":[4],"caused":[5],"by":[6],"somatic":[7],"mutations;":[8],"however,":[9],"the":[10,13,26,59,64,84,101,105,139,142],"understanding":[11],"of":[12,29,66,91,104,141,157,180,190],"causative":[14],"biological":[15],"processes":[16,31],"generating":[17],"these":[18],"mutations":[19],"limited.":[21],"A":[22],"cancer":[23,39,45,153],"genome":[24],"bears":[25],"cumulative":[27],"effects":[28],"mutational":[30,36,116],"during":[32],"tumor":[33],"development.":[34],"Deciphering":[35],"signatures":[37,57,93,117,144,181],"in":[38,44,58,94,118,145,194],"new":[42],"topic":[43],"research.":[46],"The":[47,89],"Wellcome":[48],"Trust":[49],"Sanger":[50],"Institute":[51],"(WTSI)":[52],"has":[53],"categorized":[54],"30":[55],"reference":[56],"COSMIC":[60,106],"database":[61,114],"based":[62],"on":[63,174],"analyses":[65,123],"\u223c10":[67],"000":[68],"sequencing":[69],"datasets":[70],"from":[71,150],"TCGA":[72],"and":[73,77,120,134,161],"ICGC.":[74],"Large":[75],"cohorts":[76,96],"bioinformatics":[78],"skills":[79],"are":[80],"required":[81],"to":[82,111,126,137,170],"perform":[83,171],"same":[85],"analysis":[86,173],"as":[87],"WTSI.":[88],"quantification":[90],"known":[92],"custom":[95],"not":[98,192],"possible":[99],"under":[100],"current":[102],"framework":[103],"database,":[107],"which":[108,185],"motivates":[109],"us":[110],"construct":[112],"for":[115],"cancers":[119],"make":[121],"such":[122],"more":[124],"accessible":[125],"general":[127],"researchers.":[128],"mSignatureDB":[129,166,191],"(http://tardis.cgu.edu.tw/msignaturedb)":[130],"integrates":[131],"R":[132],"packages":[133],"in-house":[135],"scripts":[136],"determine":[138],"contributions":[140,179],"published":[143],"15":[146],"780":[147],"individual":[148],"tumors":[149],"73":[151],"TCGA/ICGC":[152],"projects,":[154],"making":[155],"comparison":[156],"signature":[158,172],"patterns":[159],"within":[160],"between":[162],"projects":[163],"become":[164],"possible.":[165],"also":[167],"allows":[168],"users":[169],"their":[175],"own":[176],"datasets,":[177],"quantifying":[178],"at":[182],"sample":[183],"resolution,":[184],"unique":[188],"feature":[189],"available":[193],"other":[195],"related":[196],"databases.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
