{"id":"https://openalex.org/W2343879804","doi":"https://doi.org/10.1093/nar/gkw335","title":"systemsDock: a web server for network pharmacology-based prediction and analysis","display_name":"systemsDock: a web server for network pharmacology-based prediction and analysis","publication_year":2016,"publication_date":"2016-04-29","ids":{"openalex":"https://openalex.org/W2343879804","doi":"https://doi.org/10.1093/nar/gkw335","mag":"2343879804","pmid":"https://pubmed.ncbi.nlm.nih.gov/27131384"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkw335","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkw335","pdf_url":"https://academic.oup.com/nar/article-pdf/44/W1/W507/18787657/gkw335.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/44/W1/W507/18787657/gkw335.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051795182","display_name":"Kun\u2010Yi Hsin","orcid":"https://orcid.org/0000-0001-7220-3454"},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kun-Yi Hsin","raw_affiliation_strings":["Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan kunyi.hsin@oist.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan kunyi.hsin@oist.jp","institution_ids":["https://openalex.org/I142637625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101616697","display_name":"Yukiko Matsuoka","orcid":"https://orcid.org/0000-0002-5171-9096"},"institutions":[{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Matsuoka","raw_affiliation_strings":["The Systems Biology Institute, Minato, Tokyo 108-0071, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Systems Biology Institute, Minato, Tokyo 108-0071, Japan","institution_ids":["https://openalex.org/I4210118579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076163894","display_name":"Yoshiyuki Asai","orcid":"https://orcid.org/0000-0001-5519-4306"},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Asai","raw_affiliation_strings":["Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan","institution_ids":["https://openalex.org/I142637625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017994751","display_name":"Kyota Kamiyoshi","orcid":null},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyota Kamiyoshi","raw_affiliation_strings":["Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan","institution_ids":["https://openalex.org/I142637625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052289698","display_name":"Tokiko Watanabe","orcid":"https://orcid.org/0000-0001-6461-5379"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tokiko Watanabe","raw_affiliation_strings":["Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Minato, Tokyo 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Minato, Tokyo 108-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076363097","display_name":"Yoshihiro Kawaoka","orcid":"https://orcid.org/0000-0001-5061-8296"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshihiro Kawaoka","raw_affiliation_strings":["Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Minato, Tokyo 108-8639, Japan Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Minato, Tokyo 108-8639, Japan Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086835862","display_name":"Hiroaki Kitano","orcid":"https://orcid.org/0000-0002-3589-1953"},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Kitano","raw_affiliation_strings":["Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan The Systems Biology Institute, Minato, Tokyo 108-0071, Japan Laboratory for Disease Systems Modeling, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa 230-0045, Japan kitano@sbi.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Open Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0412, Japan The Systems Biology Institute, Minato, Tokyo 108-0071, Japan Laboratory for Disease Systems Modeling, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa 230-0045, Japan kitano@sbi.jp","institution_ids":["https://openalex.org/I142637625"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":18.2599,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.99333456,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"44","issue":"W1","first_page":"W507","last_page":"W513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9828000068664551,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.7365299463272095},{"id":"https://openalex.org/keywords/upload","display_name":"Upload","score":0.6545775532722473},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.6339871287345886},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5582618713378906},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5498421788215637},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5272706151008606},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4984769821166992},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4740821123123169},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4212700128555298},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.4143292307853699},{"id":"https://openalex.org/keywords/graphical-user-interface","display_name":"Graphical user interface","score":0.4105485677719116},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.3682892322540283},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33907943964004517},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.29414746165275574},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.18189483880996704},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14246994256973267},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.1380332112312317},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11406370997428894}],"concepts":[{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.7365299463272095},{"id":"https://openalex.org/C71901391","wikidata":"https://www.wikidata.org/wiki/Q7126699","display_name":"Upload","level":2,"score":0.6545775532722473},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.6339871287345886},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5582618713378906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5498421788215637},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5272706151008606},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4984769821166992},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4740821123123169},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4212700128555298},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.4143292307853699},{"id":"https://openalex.org/C37789001","wikidata":"https://www.wikidata.org/wiki/Q782543","display_name":"Graphical user interface","level":2,"score":0.4105485677719116},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.3682892322540283},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33907943964004517},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.29414746165275574},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18189483880996704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14246994256973267},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.1380332112312317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11406370997428894},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000146","descriptor_name":"Acids, Carbocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000146","descriptor_name":"Acids, Carbocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000146","descriptor_name":"Acids, Carbocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000146","descriptor_name":"Acids, Carbocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053139","descriptor_name":"Oseltamivir","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkw335","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkw335","pdf_url":"https://academic.oup.com/nar/article-pdf/44/W1/W507/18787657/gkw335.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:27131384","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27131384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:3952880","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4987901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:nar:44/W1/W507","is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/44/W1/W507","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/nar/gkw335","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkw335","pdf_url":"https://academic.oup.com/nar/article-pdf/44/W1/W507/18787657/gkw335.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5}],"awards":[{"id":"https://openalex.org/G2242245455","display_name":"Development of an intelligent dynamic docking pipeline for improving molecular docking simulations.","funder_award_id":"26730152","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1544009106","https://openalex.org/W1967032556","https://openalex.org/W1975875968","https://openalex.org/W1989277387","https://openalex.org/W1995576455","https://openalex.org/W1998767819","https://openalex.org/W2011226251","https://openalex.org/W2018518196","https://openalex.org/W2022472106","https://openalex.org/W2033591223","https://openalex.org/W2043274355","https://openalex.org/W2043460027","https://openalex.org/W2043950247","https://openalex.org/W2052666656","https://openalex.org/W2062518448","https://openalex.org/W2081912151","https://openalex.org/W2085564033","https://openalex.org/W2086286404","https://openalex.org/W2096864392","https://openalex.org/W2111804766","https://openalex.org/W2111967267","https://openalex.org/W2114162221","https://openalex.org/W2120898782","https://openalex.org/W2125947965","https://openalex.org/W2127553917","https://openalex.org/W2134967712","https://openalex.org/W2144472252","https://openalex.org/W2145126338","https://openalex.org/W2146111380","https://openalex.org/W2153258203","https://openalex.org/W2153921000","https://openalex.org/W2157825442","https://openalex.org/W2159594706","https://openalex.org/W2161682775","https://openalex.org/W2168938595","https://openalex.org/W2404737222","https://openalex.org/W2605068739","https://openalex.org/W4212920271","https://openalex.org/W4237335579","https://openalex.org/W4242729757"],"related_works":["https://openalex.org/W4234342421","https://openalex.org/W2909040123","https://openalex.org/W2944930475","https://openalex.org/W4377691403","https://openalex.org/W4205574495","https://openalex.org/W4307273983","https://openalex.org/W4386529428","https://openalex.org/W2343879804","https://openalex.org/W4393393567","https://openalex.org/W4385683863"],"abstract_inverted_index":{"We":[0],"present":[1],"systemsDock,":[2],"a":[3,32,60,96,115],"web":[4],"server":[5],"for":[6,20,43,64],"network":[7],"pharmacology-based":[8],"prediction":[9],"and":[10,16,26,54,69],"analysis,":[11],"which":[12],"permits":[13],"docking":[14,45],"simulation":[15],"molecular":[17,34,44,85],"pathway":[18],"map":[19],"comprehensive":[21],"characterization":[22],"of":[23,28,56,95],"ligand":[24,29],"selectivity":[25],"interpretation":[27],"action":[30],"on":[31,82],"complex":[33],"network.":[35],"It":[36],"incorporates":[37],"an":[38,83],"elaborately":[39],"designed":[40],"scoring":[41],"function":[42],"to":[46,90,106,113],"assess":[47],"protein-ligand":[48],"binding":[49,73],"potential.":[50],"For":[51],"large-scale":[52],"screening":[53],"ease":[55],"investigation,":[57],"systemsDock":[58,109,120],"has":[59],"user-friendly":[61],"GUI":[62],"interface":[63],"molecule":[65],"preparation,":[66],"parameter":[67],"specification":[68],"result":[70],"inspection.":[71],"Ligand":[72],"potentials":[74],"against":[75],"individual":[76],"proteins":[77],"can":[78,110],"be":[79,111],"directly":[80],"displayed":[81],"uploaded":[84],"interaction":[86],"map,":[87],"allowing":[88],"users":[89],"systemically":[91],"investigate":[92],"network-dependent":[93],"effects":[94],"drug":[97,99],"or":[98],"candidate.":[100],"A":[101],"case":[102],"study":[103],"is":[104,121],"given":[105],"demonstrate":[107],"how":[108],"used":[112],"discover":[114],"test":[116],"compound's":[117],"multi-target":[118],"activity.":[119],"freely":[122],"accessible":[123],"at":[124],"http://systemsdock.unit.oist.jp/.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-09T07:52:08.696243","created_date":"2025-10-10T00:00:00"}