{"id":"https://openalex.org/W1528814602","doi":"https://doi.org/10.1093/nar/gkv572","title":"I-COMS: Interprotein-COrrelated Mutations Server","display_name":"I-COMS: Interprotein-COrrelated Mutations Server","publication_year":2015,"publication_date":"2015-06-01","ids":{"openalex":"https://openalex.org/W1528814602","doi":"https://doi.org/10.1093/nar/gkv572","mag":"1528814602","pmid":"https://pubmed.ncbi.nlm.nih.gov/26032772"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkv572","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv572","pdf_url":"https://academic.oup.com/nar/article-pdf/43/W1/W320/17436173/gkv572.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/43/W1/W320/17436173/gkv572.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090711225","display_name":"Javier Iserte","orcid":"https://orcid.org/0000-0003-0056-1177"},"institutions":[{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Javier Iserte","raw_affiliation_strings":["Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina"],"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2801749607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069445871","display_name":"Franco L. Simonetti","orcid":"https://orcid.org/0000-0002-6472-9998"},"institutions":[{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Franco L. Simonetti","raw_affiliation_strings":["Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina"],"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2801749607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012336829","display_name":"Diego Javier Zea","orcid":"https://orcid.org/0000-0002-4254-9320"},"institutions":[{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Diego J. Zea","raw_affiliation_strings":["Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina"],"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2801749607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063996071","display_name":"Elin Teppa","orcid":"https://orcid.org/0000-0002-0691-9654"},"institutions":[{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Elin Teppa","raw_affiliation_strings":["Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina"],"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2801749607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000071168","display_name":"Cristina Marino\u2010Buslje","orcid":"https://orcid.org/0000-0002-6564-1920"},"institutions":[{"id":"https://openalex.org/I2801749607","display_name":"Fundaci\u00f3n Instituto Leloir","ror":"https://ror.org/0431v7h69","country_code":"AR","type":"facility","lineage":["https://openalex.org/I2801749607"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Cristina Marino-Buslje","raw_affiliation_strings":["Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina cmb@leloir.org.ar","Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina"],"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina cmb@leloir.org.ar","institution_ids":[]},{"raw_affiliation_string":"Fundaci\u00f3n Instituto Leloir. Av. Patricias Argentinas 435, C1405BWE, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2801749607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5090711225"],"corresponding_institution_ids":["https://openalex.org/I2801749607"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":2.2636,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.8782313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"43","issue":"W1","first_page":"W320","last_page":"W325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9152649641036987},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4441830813884735},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.43624746799468994},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33626189827919006},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2006901204586029}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9152649641036987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4441830813884735},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43624746799468994},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33626189827919006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2006901204586029}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkv572","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv572","pdf_url":"https://academic.oup.com/nar/article-pdf/43/W1/W320/17436173/gkv572.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:26032772","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26032772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:americanae.aecid.es:3116527","is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3116527","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:3458181","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4489276","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/10480","is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/10480","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkv572","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkv572","pdf_url":"https://academic.oup.com/nar/article-pdf/43/W1/W320/17436173/gkv572.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1528814602.pdf","grobid_xml":"https://content.openalex.org/works/W1528814602.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1982583124","https://openalex.org/W1997842212","https://openalex.org/W2007447692","https://openalex.org/W2008545402","https://openalex.org/W2008746869","https://openalex.org/W2013425283","https://openalex.org/W2041386815","https://openalex.org/W2044100153","https://openalex.org/W2045534443","https://openalex.org/W2061042699","https://openalex.org/W2096173332","https://openalex.org/W2107648570","https://openalex.org/W2107867854","https://openalex.org/W2114340287","https://openalex.org/W2115315232","https://openalex.org/W2117602634","https://openalex.org/W2119843684","https://openalex.org/W2120836664","https://openalex.org/W2137566700","https://openalex.org/W2137995988","https://openalex.org/W2139754669","https://openalex.org/W2146891463","https://openalex.org/W2153819533","https://openalex.org/W2158266834","https://openalex.org/W2166701319","https://openalex.org/W2169478909","https://openalex.org/W2170564629","https://openalex.org/W2915975108"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2151865869","https://openalex.org/W2146849562","https://openalex.org/W2028961943"],"abstract_inverted_index":{"Interprotein":[0],"contact":[1],"prediction":[2],"using":[3,94],"multiple":[4],"sequence":[5],"alignments":[6],"(MSAs)":[7],"is":[8,45,51,65,128,156],"a":[9,84,108,119,144,149],"useful":[10],"approach":[11],"to":[12,29,69],"help":[13],"detect":[14],"protein-protein":[15],"interfaces.":[16],"Different":[17],"computational":[18],"methods":[19,127],"have":[20],"been":[21],"developed":[22],"in":[23,38,118],"recent":[24],"years":[25],"as":[26,34,130,132,143],"an":[27],"approximation":[28],"solve":[30],"this":[31,58],"problem.":[32],"However,":[33],"there":[35,44],"are":[36,171],"discrepancies":[37],"the":[39,52,100,104,133,153,160,165,175],"results":[40,92,176],"provided":[41],"by":[42,77],"them,":[43],"still":[46],"no":[47],"consensus":[48],"on":[49],"which":[50],"best":[53],"performing":[54],"methodology.":[55],"To":[56],"address":[57],"problem,":[59],"I-COMS":[60,67,97],"(interprotein":[61],"COrrelated":[62],"Mutations":[63],"Server)":[64],"presented.":[66],"allows":[68],"estimate":[70],"covariation":[71,80],"between":[72,124,135],"residues":[73],"of":[74,111,147,152,164],"different":[75,79,95],"proteins":[76],"four":[78,139],"methods.":[81,96],"It":[82],"provides":[83],"graphical":[85],"and":[86,106,159,168,183,187],"interactive":[87],"output":[88],"that":[89],"helps":[90],"compare":[91],"obtained":[93],"automatically":[98],"builds":[99],"required":[101],"MSA":[102],"for":[103,185,190],"calculation":[105],"produces":[107],"rich":[109],"visualization":[110,151,188],"either":[112],"intraprotein":[113],"and/or":[114,189],"interprotein":[115],"covariating":[116],"positions":[117],"circos":[120],"representation.":[121],"Furthermore,":[122],"comparison":[123,186],"any":[125,136],"two":[126],"available":[129,158],"well":[131],"overlap":[134],"or":[137],"all":[138,174],"methodologies.":[140],"In":[141],"addition,":[142],"complementary":[145],"source":[146],"information,":[148],"matrix":[150],"corresponding":[154],"scores":[155,170,182],"made":[157],"density":[161],"plot":[162],"distribution":[163],"inter,":[166],"intra":[167],"inter+intra":[169],"calculated.":[172],"Finally,":[173],"can":[177],"be":[178],"downloaded":[179],"(including":[180],"MSAs,":[181],"graphics)":[184],"further":[191],"analysis.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}