{"id":"https://openalex.org/W2137134402","doi":"https://doi.org/10.1093/nar/gku428","title":"MODEST: a web-based design tool for oligonucleotide-mediated genome engineering and recombineering","display_name":"MODEST: a web-based design tool for oligonucleotide-mediated genome engineering and recombineering","publication_year":2014,"publication_date":"2014-05-16","ids":{"openalex":"https://openalex.org/W2137134402","doi":"https://doi.org/10.1093/nar/gku428","mag":"2137134402","pmid":"https://pubmed.ncbi.nlm.nih.gov/24838561"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gku428","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku428","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W408/7447074/gku428.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/42/W1/W408/7447074/gku428.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109051907","display_name":"Mads Bonde","orcid":null},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Mads T. Bonde","raw_affiliation_strings":["Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark msom@bio.dtu.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark msom@bio.dtu.dk","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057838429","display_name":"Michael Schantz Klausen","orcid":"https://orcid.org/0000-0003-2225-5701"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael S. Klausen","raw_affiliation_strings":["Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009861247","display_name":"Mads Valdemar Anderson","orcid":"https://orcid.org/0000-0002-6217-1353"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mads V. Anderson","raw_affiliation_strings":["Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113680970","display_name":"Annika I. Nilsson Wallin","orcid":null},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Annika I.N. Wallin","raw_affiliation_strings":["Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011136095","display_name":"Harris H. Wang","orcid":"https://orcid.org/0000-0003-2164-4318"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harris H. Wang","raw_affiliation_strings":["Department of Systems Biology, Columbia University College of Physicians and Surgeons, NY 10032, USA msom@bio.dtu.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Columbia University College of Physicians and Surgeons, NY 10032, USA msom@bio.dtu.dk","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077988966","display_name":"Morten Otto Alexander Sommer","orcid":"https://orcid.org/0000-0003-4005-5674"},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Morten O.A. Sommer","raw_affiliation_strings":["Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark msom@bio.dtu.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 H\u00f8rsholm, Denmark Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark msom@bio.dtu.dk","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5011136095","https://openalex.org/A5077988966","https://openalex.org/A5109051907"],"corresponding_institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I78577930","https://openalex.org/I96673099"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":2.988,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.91855948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"42","issue":"W1","first_page":"W408","last_page":"W415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombineering","display_name":"Recombineering","score":0.969948410987854},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7835278511047363},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6773487329483032},{"id":"https://openalex.org/keywords/genome-engineering","display_name":"Genome engineering","score":0.6508530974388123},{"id":"https://openalex.org/keywords/oligonucleotide","display_name":"Oligonucleotide","score":0.5532118082046509},{"id":"https://openalex.org/keywords/genome-editing","display_name":"Genome editing","score":0.5530663728713989},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5351159572601318},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.47044509649276733},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.387712299823761}],"concepts":[{"id":"https://openalex.org/C70239388","wikidata":"https://www.wikidata.org/wiki/Q920203","display_name":"Recombineering","level":4,"score":0.969948410987854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7835278511047363},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6773487329483032},{"id":"https://openalex.org/C145290725","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome engineering","level":5,"score":0.6508530974388123},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5532118082046509},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.5530663728713989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5351159572601318},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.47044509649276733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.387712299823761}],"mesh":[{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gku428","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku428","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W408/7447074/gku428.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:24838561","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24838561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:3176826","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4086063","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/ede9c26a-34db-4bc5-b677-4dfc7973ddfd","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/ede9c26a-34db-4bc5-b677-4dfc7973ddfd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bonde , M , Klausen , M S , Anderson , M V , Nilsson Wallin , A , Wang , H H &amp; Sommer , M O A 2014 , ' MODEST: a web-based design tool for oligonucleotide-mediated genome engineering and recombineering ' , Nucleic Acids Research , vol. 12 , no. W1 , pp. W408-W415 . https://doi.org/10.1093/nar/gku428","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/nar/gku428","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku428","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W408/7447074/gku428.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.5}],"awards":[{"id":"https://openalex.org/G1835028175","display_name":null,"funder_award_id":"NNF13SA0009311","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G2156420931","display_name":null,"funder_award_id":"NNF13SA0006019","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G3494593282","display_name":null,"funder_award_id":"DP5 OD009172","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3804538982","display_name":null,"funder_award_id":"1DP5OD009172","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5304752851","display_name":null,"funder_award_id":"NNF14OC0011335","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G5591763403","display_name":null,"funder_award_id":"R77-2010-6772","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G7501435794","display_name":null,"funder_award_id":"R140-2013-13496","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G7701966108","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137134402.pdf","grobid_xml":"https://content.openalex.org/works/W2137134402.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W89691187","https://openalex.org/W193111756","https://openalex.org/W1572955611","https://openalex.org/W1597706728","https://openalex.org/W1966510955","https://openalex.org/W1974248650","https://openalex.org/W1999009004","https://openalex.org/W2018419595","https://openalex.org/W2021313883","https://openalex.org/W2025977200","https://openalex.org/W2038178607","https://openalex.org/W2051482716","https://openalex.org/W2052024371","https://openalex.org/W2085963382","https://openalex.org/W2086561953","https://openalex.org/W2109550125","https://openalex.org/W2111967267","https://openalex.org/W2114850508","https://openalex.org/W2118846767","https://openalex.org/W2129627043","https://openalex.org/W2132922290","https://openalex.org/W2134334110","https://openalex.org/W2135995702","https://openalex.org/W2138840910","https://openalex.org/W2144779133","https://openalex.org/W2145668475","https://openalex.org/W2145730636","https://openalex.org/W2152199066","https://openalex.org/W2152208990","https://openalex.org/W2152364643","https://openalex.org/W2164330524","https://openalex.org/W2166064969","https://openalex.org/W2166417119","https://openalex.org/W6641842422"],"related_works":["https://openalex.org/W2001873174","https://openalex.org/W2273981063","https://openalex.org/W2219286889","https://openalex.org/W4313260498","https://openalex.org/W2770215042","https://openalex.org/W2337216375","https://openalex.org/W2693098264","https://openalex.org/W2138734944","https://openalex.org/W3156022767","https://openalex.org/W2769919647"],"abstract_inverted_index":{"Recombineering":[0],"and":[1,53,131,145,172,179],"multiplex":[2],"automated":[3],"genome":[4],"engineering":[5],"(MAGE)":[6],"offer":[7],"the":[8,67,87,101,122,162],"possibility":[9],"to":[10,80,182],"rapidly":[11],"modify":[12],"multiple":[13],"genomic":[14,63],"or":[15,136,157],"plasmid":[16],"sites":[17],"at":[18,185],"high":[19,169],"efficiencies.":[20],"This":[21,107],"enables":[22],"efficient":[23],"creation":[24],"of":[25,44,76,112],"genetic":[26,89],"variants":[27],"including":[28,139],"both":[29],"single":[30],"mutants":[31],"with":[32],"specifically":[33],"targeted":[34],"modifications":[35],"as":[36,38],"well":[37],"combinatorial":[39],"cell":[40],"libraries.":[41],"Manual":[42],"design":[43],"oligonucleotides":[45],"for":[46,58,115,168,177],"these":[47,96],"approaches":[48],"can":[49,165],"be":[50,56,166],"tedious,":[51],"time-consuming,":[52],"may":[54],"not":[55],"practical":[57],"larger":[59],"projects":[60],"targeting":[61],"many":[62],"sites.":[64],"At":[65],"present,":[66],"change":[68],"from":[69],"a":[70,77,81],"desired":[71,155],"phenotype":[72],"(e.g.":[73],"altered":[74],"expression":[75],"specific":[78],"protein)":[79],"designed":[82],"MAGE":[83,102,113],"oligo,":[84],"which":[85,164],"confers":[86],"corresponding":[88],"change,":[90],"is":[91,175,180],"performed":[92],"manually.":[93],"To":[94],"address":[95],"challenges,":[97],"we":[98],"have":[99],"developed":[100],"Oligo":[103],"Design":[104],"Tool":[105],"(MODEST).":[106],"web-based":[108],"tool":[109,149],"allows":[110],"designing":[111],"oligos":[114,152],"(i)":[116],"tuning":[117],"translation":[118],"rates":[119],"by":[120,161],"modifying":[121],"ribosomal":[123],"binding":[124],"site,":[125],"(ii)":[126],"generating":[127],"translational":[128],"gene":[129],"knockouts":[130],"(iii)":[132],"introducing":[133],"other":[134],"coding":[135],"non-coding":[137],"mutations,":[138],"amino":[140],"acid":[141],"substitutions,":[142],"insertions,":[143],"deletions":[144],"point":[146],"mutations.":[147],"The":[148],"automatically":[150],"designs":[151],"based":[153],"on":[154],"genotypic":[156],"phenotypic":[158],"changes":[159],"defined":[160],"user,":[163],"used":[167],"efficiency":[170],"recombineering":[171],"MAGE.":[173],"MODEST":[174],"available":[176],"free":[178],"open":[181],"all":[183],"users":[184],"http://modest.biosustain.dtu.dk.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
