{"id":"https://openalex.org/W2123957354","doi":"https://doi.org/10.1093/nar/gku319","title":"TSpred: a web server for the rational design of temperature-sensitive mutants","display_name":"TSpred: a web server for the rational design of temperature-sensitive mutants","publication_year":2014,"publication_date":"2014-04-29","ids":{"openalex":"https://openalex.org/W2123957354","doi":"https://doi.org/10.1093/nar/gku319","mag":"2123957354","pmid":"https://pubmed.ncbi.nlm.nih.gov/24782523"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gku319","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku319","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W277/7436639/gku319.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/42/W1/W277/7436639/gku319.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008614446","display_name":"Kuan Pern Tan","orcid":"https://orcid.org/0000-0002-6496-3493"},"institutions":[{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kuan Pern Tan","raw_affiliation_strings":["Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671 School of Computer Engineering, Nanyang Technological University, Singapore 639798","Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671","School of Computer Engineering, Nanyang Technological University, Singapore 639798"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671 School of Computer Engineering, Nanyang Technological University, Singapore 639798","institution_ids":[]},{"raw_affiliation_string":"Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671","institution_ids":["https://openalex.org/I4210148498"]},{"raw_affiliation_string":"School of Computer Engineering, Nanyang Technological University, Singapore 639798","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109959297","display_name":"Shruti Khare","orcid":"https://orcid.org/0000-0001-5622-2663"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shruti Khare","raw_affiliation_strings":["Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India"],"affiliations":[{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112470048","display_name":"Raghavan Varadarajan","orcid":null},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Raghavan Varadarajan","raw_affiliation_strings":["Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India madhusudhan@iiserpune.ac.in","Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India"],"affiliations":[{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India madhusudhan@iiserpune.ac.in","institution_ids":[]},{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070485625","display_name":"M. S. Madhusudhan","orcid":"https://orcid.org/0000-0002-2889-5884"},"institutions":[{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]},{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["IN","SG"],"is_corresponding":true,"raw_author_name":"Mallur Srivatsan Madhusudhan","raw_affiliation_strings":["Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671 Indian Institute of Science Education and Research, Pune 411008, India Department of Biological Sciences, National University of Singapore, Singapore 117543 madhusudhan@iiserpune.ac.in","Indian Institute of Science Education and Research, Pune 411008, India","Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671","Department of Biological Sciences, National University of Singapore, Singapore 117543"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671 Indian Institute of Science Education and Research, Pune 411008, India Department of Biological Sciences, National University of Singapore, Singapore 117543 madhusudhan@iiserpune.ac.in","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Science Education and Research, Pune 411008, India","institution_ids":["https://openalex.org/I181996519"]},{"raw_affiliation_string":"Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, Singapore 138671","institution_ids":["https://openalex.org/I4210148498"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore 117543","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070485625","https://openalex.org/A5112470048"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I181996519","https://openalex.org/I4210148498","https://openalex.org/I59270414"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.5704,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.67913263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"W1","first_page":"W277","last_page":"W284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.8035706281661987},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7850637435913086},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.7287477254867554},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"Mutagenesis","score":0.6002538204193115},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.567821204662323},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5417462587356567},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.5385512113571167},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3884211480617523},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2350168526172638},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17638751864433289},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.13156214356422424},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.10609027743339539},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.10559266805648804}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8035706281661987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7850637435913086},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.7287477254867554},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6002538204193115},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.567821204662323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5417462587356567},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.5385512113571167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3884211480617523},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2350168526172638},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17638751864433289},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.13156214356422424},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.10609027743339539},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10559266805648804}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1093/nar/gku319","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku319","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W277/7436639/gku319.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:24782523","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24782523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:eprints.iisc.ac.in:49730","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.945","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.945","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/55/42/gku319.PMC4086094.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.863.4484","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.863.4484","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/42/W1/W277.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.877.2984","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.877.2984","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2014/04/29/nar.gku319.full.pdf","raw_type":"text"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/104966","is_oa":true,"landing_page_url":"http://hdl.handle.net/10220/20390","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3176834","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4086094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gku319","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku319","pdf_url":"https://academic.oup.com/nar/article-pdf/42/W1/W277/7436639/gku319.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2123957354.pdf","grobid_xml":"https://content.openalex.org/works/W2123957354.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W166411003","https://openalex.org/W1547033864","https://openalex.org/W1966261221","https://openalex.org/W1966480910","https://openalex.org/W1970492002","https://openalex.org/W1971149989","https://openalex.org/W1972412311","https://openalex.org/W1980490260","https://openalex.org/W1981031877","https://openalex.org/W1989417429","https://openalex.org/W1993882349","https://openalex.org/W1995893329","https://openalex.org/W1997870466","https://openalex.org/W1999613945","https://openalex.org/W2004192483","https://openalex.org/W2011402521","https://openalex.org/W2012781528","https://openalex.org/W2014715442","https://openalex.org/W2015165314","https://openalex.org/W2018582505","https://openalex.org/W2026377725","https://openalex.org/W2028609241","https://openalex.org/W2030335147","https://openalex.org/W2035487814","https://openalex.org/W2036425095","https://openalex.org/W2041474954","https://openalex.org/W2048599311","https://openalex.org/W2052513192","https://openalex.org/W2052538982","https://openalex.org/W2053418558","https://openalex.org/W2055043387","https://openalex.org/W2056240197","https://openalex.org/W2064815984","https://openalex.org/W2065283382","https://openalex.org/W2067130595","https://openalex.org/W2080918762","https://openalex.org/W2082507962","https://openalex.org/W2082968224","https://openalex.org/W2084743099","https://openalex.org/W2090607082","https://openalex.org/W2096070431","https://openalex.org/W2108376320","https://openalex.org/W2112443513","https://openalex.org/W2130479394","https://openalex.org/W2132629607","https://openalex.org/W2143210482","https://openalex.org/W2157255054","https://openalex.org/W2158649428","https://openalex.org/W2158919479","https://openalex.org/W2162120660","https://openalex.org/W2168926448","https://openalex.org/W2172460140","https://openalex.org/W2178996695","https://openalex.org/W2420579883","https://openalex.org/W2612240612","https://openalex.org/W2914405292","https://openalex.org/W4212865600","https://openalex.org/W6606797138"],"related_works":["https://openalex.org/W2155835698","https://openalex.org/W2377600730","https://openalex.org/W2387405353","https://openalex.org/W2352453461","https://openalex.org/W2050054436","https://openalex.org/W2417618367","https://openalex.org/W1983164158","https://openalex.org/W2084262300","https://openalex.org/W2885204620","https://openalex.org/W2502312529"],"abstract_inverted_index":{"Temperature":[0],"sensitive":[1],"(Ts)":[2],"mutants":[3,39,64],"of":[4,14,28,68,99,130,153],"proteins":[5,67,149],"provide":[6],"experimentalists":[7],"with":[8,133],"a":[9,127],"powerful":[10],"and":[11,30,45,73,80,132,142,146,150],"reversible":[12],"way":[13],"conditionally":[15],"expressing":[16],"genes.":[17],"The":[18,136],"technique":[19],"has":[20,104],"been":[21,105],"widely":[22],"used":[23],"in":[24,33,108,111],"determining":[25],"the":[26,97],"role":[27],"gene":[29,31],"products":[32],"several":[34],"cellular":[35],"processes.":[36],"Traditionally,":[37],"Ts":[38,63,100,121],"are":[40],"generated":[41],"by":[42],"random":[43],"mutagenesis":[44],"then":[46],"selected":[47],"though":[48],"laborious":[49],"large-scale":[50],"screening.":[51],"Our":[52,102],"web":[53,138],"server,":[54],"TSpred":[55,70],"(http://mspc.bii.a-star.edu.sg/TSpred/),":[56],"now":[57],"enables":[58],"users":[59],"to":[60,87,96,144],"rationally":[61],"design":[62],"for":[65,120],"their":[66],"interest.":[69],"uses":[71],"hydrophobicity":[72],"hydrophobic":[74,90],"moment,":[75],"deduced":[76],"from":[77,84],"primary":[78],"sequence":[79],"residue":[81],"depth,":[82],"inferred":[83],"3D":[85],"structures":[86],"predict/identify":[88],"buried":[89],"residues.":[91],"Mutating":[92],"these":[93],"residues":[94],"leads":[95],"creation":[98],"mutants.":[101],"method":[103],"experimentally":[106],"validated":[107],"36":[109],"positions":[110],"six":[112],"different":[113,154],"proteins.":[114],"It":[115],"is":[116,140],"an":[117],"attractive":[118],"proposition":[119],"mutant":[122],"engineering":[123],"as":[124],"it":[125],"proposes":[126],"small":[128],"number":[129],"mutations":[131],"high":[134],"precision.":[135],"accompanying":[137],"server":[139],"simple":[141],"intuitive":[143],"use":[145],"can":[147],"handle":[148],"protein":[151],"complexes":[152],"sizes.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
