{"id":"https://openalex.org/W2101841757","doi":"https://doi.org/10.1093/nar/gkt1176","title":"SuperPain\u2014a resource on pain-relieving compounds targeting ion channels","display_name":"SuperPain\u2014a resource on pain-relieving compounds targeting ion channels","publication_year":2013,"publication_date":"2013-11-22","ids":{"openalex":"https://openalex.org/W2101841757","doi":"https://doi.org/10.1093/nar/gkt1176","mag":"2101841757","pmid":"https://pubmed.ncbi.nlm.nih.gov/24271391"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkt1176","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkt1176","pdf_url":"https://academic.oup.com/nar/article-pdf/42/D1/D1107/3615080/gkt1176.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/42/D1/D1107/3615080/gkt1176.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bj\u00f6rn O. Gohlke","orcid":null},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn O. Gohlke","raw_affiliation_strings":["German Cancer Consortium (DKTK), Lindenberger Weg 80, 13125 Berlin, Germany, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Structural Bioinformatics Group, Lindenberger Weg 80, 13125 Berlin, Germany and Dental, Oral and Maxillary Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, CC3, Assmannshauser Stra\u00dfe 4-6, 14197 Berlin, Germany","Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Consortium (DKTK), Lindenberger Weg 80, 13125 Berlin, Germany, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Structural Bioinformatics Group, Lindenberger Weg 80, 13125 Berlin, Germany and Dental, Oral and Maxillary Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, CC3, Assmannshauser Stra\u00dfe 4-6, 14197 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043414157","display_name":"Robert Prei\u00dfner","orcid":"https://orcid.org/0000-0002-2407-1087"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Preissner","raw_affiliation_strings":["Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091510513","display_name":"Saskia Prei\u00dfner","orcid":"https://orcid.org/0000-0002-3672-0283"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Saskia Preissner","raw_affiliation_strings":["Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.3127,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55759923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"42","issue":"D1","first_page":"D1107","last_page":"D1112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.6610302329063416},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6130456328392029},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.5913508534431458},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.47158873081207275},{"id":"https://openalex.org/keywords/trpm8","display_name":"TRPM8","score":0.4648396670818329},{"id":"https://openalex.org/keywords/herg","display_name":"hERG","score":0.4612303078174591},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.41171106696128845},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36751100420951843},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.32746434211730957},{"id":"https://openalex.org/keywords/transient-receptor-potential-channel","display_name":"Transient receptor potential channel","score":0.3226647973060608},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.18902471661567688},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16824859380722046},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.11404675245285034}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.6610302329063416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6130456328392029},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.5913508534431458},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.47158873081207275},{"id":"https://openalex.org/C163146387","wikidata":"https://www.wikidata.org/wiki/Q15324395","display_name":"TRPM8","level":5,"score":0.4648396670818329},{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.4612303078174591},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41171106696128845},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36751100420951843},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32746434211730957},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.3226647973060608},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.18902471661567688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16824859380722046},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.11404675245285034}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkt1176","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkt1176","pdf_url":"https://academic.oup.com/nar/article-pdf/42/D1/D1107/3615080/gkt1176.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:24271391","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24271391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:2943118","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3964982","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkt1176","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkt1176","pdf_url":"https://academic.oup.com/nar/article-pdf/42/D1/D1107/3615080/gkt1176.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1898835919","https://openalex.org/W1967930702","https://openalex.org/W1972811533","https://openalex.org/W1973230452","https://openalex.org/W1975172985","https://openalex.org/W1978984215","https://openalex.org/W1995361060","https://openalex.org/W1999069112","https://openalex.org/W2004813038","https://openalex.org/W2012968975","https://openalex.org/W2013711061","https://openalex.org/W2026148117","https://openalex.org/W2026749563","https://openalex.org/W2035796122","https://openalex.org/W2046154655","https://openalex.org/W2051183684","https://openalex.org/W2065233304","https://openalex.org/W2069309953","https://openalex.org/W2073606727","https://openalex.org/W2074473216","https://openalex.org/W2080886752","https://openalex.org/W2093343039","https://openalex.org/W2096864392","https://openalex.org/W2104216897","https://openalex.org/W2108579966","https://openalex.org/W2115893714","https://openalex.org/W2134815007","https://openalex.org/W2135567029","https://openalex.org/W2144195410","https://openalex.org/W2147196890","https://openalex.org/W2148159408","https://openalex.org/W2150556577","https://openalex.org/W2155283661","https://openalex.org/W2164998622","https://openalex.org/W2168881222","https://openalex.org/W2170161289","https://openalex.org/W2170638943","https://openalex.org/W2272113778"],"related_works":["https://openalex.org/W4381158434","https://openalex.org/W231299636","https://openalex.org/W2184590647","https://openalex.org/W1542157645","https://openalex.org/W2152585394","https://openalex.org/W2051613742","https://openalex.org/W8184359","https://openalex.org/W2232969135","https://openalex.org/W2084064882","https://openalex.org/W2028264226"],"abstract_inverted_index":{"Pain":[0],"is":[1,16,35,51],"more":[2,44],"than":[3],"an":[4],"unpleasant":[5],"sensory":[6],"experience":[7],"associated":[8],"with":[9],"actual":[10],"or":[11,62],"potential":[12],"tissue":[13],"damage:":[14],"it":[15],"the":[17,72,78,118,140,158],"most":[18],"common":[19],"reason":[20],"for":[21,43,55,139],"physician":[22],"consultation":[23],"and":[24,38,46,57,92,125,132],"often":[25,36],"dramatically":[26],"affects":[27],"quality":[28],"of":[29,33,74,99,123,142,154],"life.":[30],"The":[31,96],"management":[32],"pain":[34,75],"difficult":[37],"new":[39,143],"targets":[40],"are":[41,69,103,115],"required":[42],"effective":[45],"specific":[47],"treatment.":[48],"SuperPain":[49],"(http://bioinformatics.charite.de/superpain/)":[50],"freely":[52],"available":[53],"database":[54,97,119],"pain-stimulating":[56],"pain-relieving":[58],"compounds,":[59],"which":[60,102],"bind":[61,64],"potentially":[63],"to":[65,77],"ion":[66],"channels":[67],"that":[68],"involved":[70],"in":[71],"transmission":[73],"signals":[76],"central":[79],"nervous":[80],"system,":[81],"such":[82],"as":[83],"TRPV1,":[84],"TRPM8,":[85],"TRPA1,":[86],"TREK1,":[87],"TRESK,":[88],"hERG,":[89],"ASIC,":[90],"P2X":[91],"voltage-gated":[93],"sodium":[94],"channels.":[95],"consists":[98],"\u223c8700":[100],"ligands,":[101],"characterized":[104],"by":[105],"experimentally":[106],"measured":[107],"binding":[108,130],"affinities.":[109],"Additionally,":[110],"100":[111],"000":[112],"putative":[113],"ligands":[114,155],"included.":[116],"Moreover,":[117],"provides":[120],"3D":[121],"structures":[122],"receptors":[124],"predicted":[126],"ligand-binding":[127],"poses.":[128],"These":[129],"poses":[131],"a":[133],"structural":[134],"classification":[135],"scheme":[136],"provide":[137],"hints":[138],"design":[141],"analgesic":[144],"compounds.":[145],"A":[146],"user-friendly":[147],"graphical":[148],"interface":[149],"allows":[150],"similarity":[151],"searching,":[152],"visualization":[153],"docked":[156],"into":[157],"receptor,":[159],"etc.":[160]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}