{"id":"https://openalex.org/W2152124140","doi":"https://doi.org/10.1093/nar/gks1198","title":"The TissueNet database of human tissue protein\u2013protein interactions","display_name":"The TissueNet database of human tissue protein\u2013protein interactions","publication_year":2012,"publication_date":"2012-11-26","ids":{"openalex":"https://openalex.org/W2152124140","doi":"https://doi.org/10.1093/nar/gks1198","mag":"2152124140","pmid":"https://pubmed.ncbi.nlm.nih.gov/23193266"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gks1198","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks1198","pdf_url":"https://academic.oup.com/nar/article-pdf/41/D1/D841/18788663/gks1198.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/41/D1/D841/18788663/gks1198.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087751046","display_name":"Ruth Barshir","orcid":"https://orcid.org/0000-0003-0776-9587"},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ruth Barshir","raw_affiliation_strings":["Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel","Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016467381","display_name":"Omer Basha","orcid":"https://orcid.org/0000-0002-5764-1066"},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Omer Basha","raw_affiliation_strings":["Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011017408","display_name":"Amir Eluk","orcid":null},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amir Eluk","raw_affiliation_strings":["Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066757146","display_name":"Ilan Smoly","orcid":"https://orcid.org/0000-0002-5270-0266"},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ilan Y. Smoly","raw_affiliation_strings":["Department of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel and"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel and","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068562490","display_name":"Alexander Lan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Lan","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059198564","display_name":"Esti Yeger\u2010Lotem","orcid":"https://orcid.org/0000-0002-8279-7898"},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Esti Yeger-Lotem","raw_affiliation_strings":["Department of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel and","Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,","National Center for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel and","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel,","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"National Center for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel","institution_ids":["https://openalex.org/I124227911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5059198564"],"corresponding_institution_ids":["https://openalex.org/I124227911"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.2271,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.92798984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"41","issue":"D1","first_page":"D841","last_page":"D844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9237569570541382},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.431233286857605}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9237569570541382},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.431233286857605}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gks1198","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks1198","pdf_url":"https://academic.oup.com/nar/article-pdf/41/D1/D841/18788663/gks1198.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:23193266","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23193266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.790.4075","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.790.4075","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/63/db/gks1198.PMC3531115.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.964.3383","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.964.3383","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2012/11/26/nar.gks1198.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.965.3496","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.965.3496","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/41/D1/D841.full.pdf","raw_type":"text"},{"id":"pmh:oai:europepmc.org:2536447","is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3531115","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3531115","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3531115","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gks1198","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gks1198","pdf_url":"https://academic.oup.com/nar/article-pdf/41/D1/D841/18788663/gks1198.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2493519717","display_name":"A Computational Systems Biology Approach to Reveal the Molecular Basis of Complex Diseases","funder_award_id":"256360","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338368","display_name":"FP7 People: Marie-Curie Actions","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152124140.pdf","grobid_xml":"https://content.openalex.org/works/W2152124140.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1970263201","https://openalex.org/W2009405916","https://openalex.org/W2016763316","https://openalex.org/W2018740272","https://openalex.org/W2037442572","https://openalex.org/W2098174226","https://openalex.org/W2098979213","https://openalex.org/W2100488300","https://openalex.org/W2103017472","https://openalex.org/W2107249189","https://openalex.org/W2109108939","https://openalex.org/W2128900650","https://openalex.org/W2130687290","https://openalex.org/W2130925862","https://openalex.org/W2146980885","https://openalex.org/W2149671003","https://openalex.org/W2156201868","https://openalex.org/W2158948118","https://openalex.org/W2164683872","https://openalex.org/W2915108429","https://openalex.org/W2916767477","https://openalex.org/W2917375902"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W2013243191","https://openalex.org/W2117258802"],"abstract_inverted_index":{"Knowledge":[0],"of":[1,11,22,49,72,79,118,136],"protein-protein":[2],"interactions":[3,141],"(PPIs)":[4],"is":[5],"important":[6],"for":[7,132],"identifying":[8],"the":[9,14,37,109,119,134],"functions":[10],"proteins":[12,138],"and":[13,81,96,107,123,139],"processes":[15],"they":[16],"are":[17,25],"involved":[18],"in.":[19],"Although":[20],"data":[21,71,78],"human":[23,38,50,58,87,137],"PPIs":[24,43,52,75],"easily":[26],"accessible":[27],"through":[28],"several":[29],"public":[30],"databases,":[31],"these":[32,42],"databases":[33],"do":[34],"not":[35],"specify":[36],"tissues":[39,59,110],"in":[40],"which":[41],"take":[44],"place.":[45],"The":[46,115],"TissueNet":[47,92,127],"database":[48],"tissue":[51],"(http://netbio.bgu.ac.il/tissuenet/)":[53],"associates":[54],"each":[55],"interaction":[56],"with":[57,76],"that":[60],"express":[61],"both":[62,112],"pair":[63,113],"mates.":[64,114],"This":[65],"was":[66],"achieved":[67],"by":[68],"integrating":[69],"current":[70],"experimentally":[73],"detected":[74],"extensive":[77],"gene":[80],"protein":[82,95],"expression":[83],"across":[84,142],"16":[85],"main":[86],"tissues.":[88,143],"Users":[89],"can":[90],"query":[91],"using":[93,104],"a":[94,105,129],"retrieve":[97,108],"its":[98],"PPI":[99,106],"partners":[100],"per":[101],"tissue,":[102],"or":[103],"expressing":[111],"graphical":[116],"representation":[117],"output":[120],"highlights":[121],"tissue-specific":[122],"tissue-wide":[124],"PPIs.":[125],"Thus,":[126],"provides":[128],"unique":[130],"platform":[131],"assessing":[133],"roles":[135],"their":[140]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
