{"id":"https://openalex.org/W2145661853","doi":"https://doi.org/10.1093/nar/gkr799","title":"MACiE: exploring the diversity of biochemical reactions","display_name":"MACiE: exploring the diversity of biochemical reactions","publication_year":2011,"publication_date":"2011-11-03","ids":{"openalex":"https://openalex.org/W2145661853","doi":"https://doi.org/10.1093/nar/gkr799","mag":"2145661853","pmid":"https://pubmed.ncbi.nlm.nih.gov/22058127"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkr799","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr799","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D783/16955986/gkr799.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/40/D1/D783/16955986/gkr799.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087551864","display_name":"Gemma L. Holliday","orcid":"https://orcid.org/0000-0002-6731-6398"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gemma L. Holliday","raw_affiliation_strings":["EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. gemma@ebi.ac.uk","EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. gemma@ebi.ac.uk","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079457434","display_name":"Claudia Andreini","orcid":"https://orcid.org/0000-0003-4329-8225"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Claudia Andreini","raw_affiliation_strings":["EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011855731","display_name":"Julia D. Fischer","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Julia D. Fischer","raw_affiliation_strings":["EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012394374","display_name":"Syed Asad Rahman","orcid":"https://orcid.org/0000-0002-7602-6675"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Syed Asad Rahman","raw_affiliation_strings":["EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006111780","display_name":"Daniel E. Almonacid","orcid":"https://orcid.org/0000-0002-1788-2084"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Daniel E. Almonacid","raw_affiliation_strings":["EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006170697","display_name":"Sophie Williams","orcid":"https://orcid.org/0000-0002-5843-0295"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Sophie T. Williams","raw_affiliation_strings":["EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073334733","display_name":"William R. Pearson","orcid":"https://orcid.org/0000-0002-0727-3680"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"William R. Pearson","raw_affiliation_strings":["EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","University of California, San Francisco, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, 2 Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 3 Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy, 4 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158 and 5 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, United States","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087551864"],"corresponding_institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.6465,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.94211133,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"40","issue":"D1","first_page":"D783","last_page":"D789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perl","display_name":"Perl","score":0.9058001637458801},{"id":"https://openalex.org/keywords/scripting-language","display_name":"Scripting language","score":0.810964047908783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7424942851066589},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.6578493118286133},{"id":"https://openalex.org/keywords/diversity","display_name":"Diversity (politics)","score":0.4833535850048065},{"id":"https://openalex.org/keywords/chemical-space","display_name":"Chemical space","score":0.4217255413532257},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41941362619400024},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3453344404697418},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.33588355779647827},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.29736989736557007},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2816023826599121},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.23097515106201172},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.15515318512916565},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.0737234354019165}],"concepts":[{"id":"https://openalex.org/C2777002779","wikidata":"https://www.wikidata.org/wiki/Q42478","display_name":"Perl","level":2,"score":0.9058001637458801},{"id":"https://openalex.org/C61423126","wikidata":"https://www.wikidata.org/wiki/Q187432","display_name":"Scripting language","level":2,"score":0.810964047908783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7424942851066589},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.6578493118286133},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.4833535850048065},{"id":"https://openalex.org/C99726746","wikidata":"https://www.wikidata.org/wiki/Q906396","display_name":"Chemical space","level":3,"score":0.4217255413532257},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41941362619400024},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3453344404697418},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.33588355779647827},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29736989736557007},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2816023826599121},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.23097515106201172},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.15515318512916565},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.0737234354019165},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gkr799","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr799","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D783/16955986/gkr799.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3244993","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3244993","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:22058127","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22058127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.813.3068","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.813.3068","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/be/51/gkr799.PMC3244993.pdf","raw_type":"text"},{"id":"pmh:oai:flore.unifi.it:2158/777944","is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/777944","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:nar:40/D1/D783","is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/40/D1/D783","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/nar/gkr799","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr799","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D783/16955986/gkr799.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2534279603","display_name":null,"funder_award_id":"R01GM60595","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2939729635","display_name":"Laying the Foundation of Genomic Enzymology","funder_award_id":"5r01gm060595-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G712632771","display_name":null,"funder_award_id":"LM04969","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314023","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145661853.pdf","grobid_xml":"https://content.openalex.org/works/W2145661853.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1532171086","https://openalex.org/W1964640688","https://openalex.org/W1972718882","https://openalex.org/W1990598130","https://openalex.org/W1995413875","https://openalex.org/W1995808589","https://openalex.org/W1998532197","https://openalex.org/W2002635898","https://openalex.org/W2031969781","https://openalex.org/W2043799214","https://openalex.org/W2043886357","https://openalex.org/W2051628563","https://openalex.org/W2052498582","https://openalex.org/W2078880021","https://openalex.org/W2082593499","https://openalex.org/W2096729078","https://openalex.org/W2097613730","https://openalex.org/W2098770192","https://openalex.org/W2099389777","https://openalex.org/W2103017472","https://openalex.org/W2104295259","https://openalex.org/W2110679449","https://openalex.org/W2112457863","https://openalex.org/W2113723577","https://openalex.org/W2140808721","https://openalex.org/W2152500739","https://openalex.org/W2155260111","https://openalex.org/W2171437346","https://openalex.org/W2612240612","https://openalex.org/W6631996847"],"related_works":["https://openalex.org/W2331989206","https://openalex.org/W2008612003","https://openalex.org/W3173828731","https://openalex.org/W45658120","https://openalex.org/W4205178530","https://openalex.org/W613088223","https://openalex.org/W2739025131","https://openalex.org/W2606876474","https://openalex.org/W1974405519","https://openalex.org/W4287121746"],"abstract_inverted_index":{"MACiE":[0,65,111],"(which":[1],"stands":[2],"for":[3,71,106],"Mechanism,":[4],"Annotation":[5],"and":[6,17,59,90,112,123],"Classification":[7],"in":[8,69,110],"Enzymes)":[9],"is":[10],"a":[11,49,67,93],"database":[12],"of":[13,28,31,44,64,85,100,120,127],"enzyme":[14],"reaction":[15,79],"mechanisms,":[16],"can":[18,129],"be":[19,131],"accessed":[20,132],"from":[21,74],"http://www.ebi.ac.uk/thornton-srv/databases/MACiE/.":[22],"This":[23,62],"article":[24],"presents":[25],"the":[26,37,45,97,108,121],"release":[27],"Version":[29],"3":[30],"MACiE,":[32],"which":[33,128],"not":[34],"only":[35],"extends":[36],"dataset":[38],"to":[39,81,87,95],"335":[40],"entries,":[41,73],"covering":[42,77],"182":[43],"EC":[46,78],"sub-subclasses":[47],"with":[48,83,92],"crystal":[50],"structure":[51],"available":[52],"(~90%),":[53],"but":[54],"also":[55],"incorporates":[56],"greater":[57],"chemical":[58,98],"structural":[60],"detail.":[61],"version":[63],"represents":[66],"shift":[68],"emphasis":[70],"new":[72,104,118,124],"non-homologous":[75],"representatives":[76],"space":[80],"enzymes":[82],"mechanisms":[84],"interest":[86],"our":[88],"users":[89],"collaborators":[91],"view":[94],"exploring":[96,107],"diversity":[99],"life.":[101],"We":[102],"present":[103],"tools":[105],"data":[109,122],"comparing":[113],"entries":[114],"as":[115,117],"well":[116],"analyses":[119],"searches,":[125],"many":[126],"now":[130],"via":[133],"dedicated":[134],"Perl":[135],"scripts.":[136]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
