{"id":"https://openalex.org/W2143340639","doi":"https://doi.org/10.1093/nar/gkr374","title":"miRvestigator: web application to identify miRNAs responsible for co-regulated gene expression patterns discovered through transcriptome profiling","display_name":"miRvestigator: web application to identify miRNAs responsible for co-regulated gene expression patterns discovered through transcriptome profiling","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2143340639","doi":"https://doi.org/10.1093/nar/gkr374","mag":"2143340639","pmid":"https://pubmed.ncbi.nlm.nih.gov/21602264"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkr374","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr374","pdf_url":"https://academic.oup.com/nar/article-pdf/39/suppl_2/W125/7628306/gkr374.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/39/suppl_2/W125/7628306/gkr374.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074006758","display_name":"Christopher Plaisier","orcid":"https://orcid.org/0000-0003-3273-5717"},"institutions":[{"id":"https://openalex.org/I175704753","display_name":"North Seattle College","ror":"https://ror.org/02d7rnk16","country_code":"US","type":"education","lineage":["https://openalex.org/I175704753"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. L. Plaisier","raw_affiliation_strings":["Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I175704753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053723733","display_name":"J Christopher Bare","orcid":"https://orcid.org/0000-0003-1006-1491"},"institutions":[{"id":"https://openalex.org/I175704753","display_name":"North Seattle College","ror":"https://ror.org/02d7rnk16","country_code":"US","type":"education","lineage":["https://openalex.org/I175704753"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Bare","raw_affiliation_strings":["Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I175704753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005287667","display_name":"Nitin S. Baliga","orcid":"https://orcid.org/0000-0001-9157-5974"},"institutions":[{"id":"https://openalex.org/I175704753","display_name":"North Seattle College","ror":"https://ror.org/02d7rnk16","country_code":"US","type":"education","lineage":["https://openalex.org/I175704753"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. S. Baliga","raw_affiliation_strings":["Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I175704753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074006758"],"corresponding_institution_ids":["https://openalex.org/I175704753","https://openalex.org/I3148997608"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.3885,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.82326985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"39","issue":"suppl","first_page":"W125","last_page":"W131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9460039138793945},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7992914915084839},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.7210744619369507},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.641148567199707},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6309974193572998},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5381845235824585},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5339412093162537},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5247828364372253},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5159602761268616},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3462103307247162}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9460039138793945},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7992914915084839},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.7210744619369507},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.641148567199707},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6309974193572998},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5381845235824585},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5339412093162537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5247828364372253},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5159602761268616},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3462103307247162},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkr374","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr374","pdf_url":"https://academic.oup.com/nar/article-pdf/39/suppl_2/W125/7628306/gkr374.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:21602264","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21602264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:osti.gov:1797410","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1797410","pdf_url":"https://www.osti.gov/servlets/purl/1797410","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3125776","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3125776","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkr374","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr374","pdf_url":"https://academic.oup.com/nar/article-pdf/39/suppl_2/W125/7628306/gkr374.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3298729951","display_name":"Design and Implementation of Effective Solutions for Archiving and Processing Systems Biology Data:  Research Integrated with an Ongoing High School Education Program.","funder_award_id":"0640950","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4547400151","display_name":null,"funder_award_id":"GM0773","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G488925784","display_name":null,"funder_award_id":"GM07739","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5403153754","display_name":null,"funder_award_id":"P50GM076547","funder_id":"https://openalex.org/F4320310700","funder_display_name":"Universit\u00e9 du Luxembourg"},{"id":"https://openalex.org/G8042984406","display_name":null,"funder_award_id":"P50GM076547","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310700","display_name":"Universit\u00e9 du Luxembourg","ror":"https://ror.org/036x5ad56"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143340639.pdf","grobid_xml":"https://content.openalex.org/works/W2143340639.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1993799748","https://openalex.org/W2007013450","https://openalex.org/W2026570544","https://openalex.org/W2028324150","https://openalex.org/W2035459770","https://openalex.org/W2044832480","https://openalex.org/W2070571588","https://openalex.org/W2113117122","https://openalex.org/W2119804413","https://openalex.org/W2123143148","https://openalex.org/W2127640118","https://openalex.org/W2148208043","https://openalex.org/W2149785901","https://openalex.org/W2150660819","https://openalex.org/W2158217645","https://openalex.org/W2161693225","https://openalex.org/W2161732139","https://openalex.org/W2162674813"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2028462563","https://openalex.org/W2942994004","https://openalex.org/W2982720988","https://openalex.org/W3150324899","https://openalex.org/W2073305407","https://openalex.org/W2057742104","https://openalex.org/W4283692078","https://openalex.org/W1980329767"],"abstract_inverted_index":{"Transcriptome":[0],"profiling":[1],"studies":[2],"have":[3,121],"produced":[4],"staggering":[5],"numbers":[6],"of":[7,14,20,39,79,116,144,165,172,180],"gene":[8],"co-expression":[9],"signatures":[10,22],"for":[11,96,140],"a":[12,93,137,153,163],"variety":[13],"biological":[15],"systems.":[16],"A":[17],"significant":[18],"fraction":[19],"these":[21,150],"will":[23],"be":[24],"partially":[25],"or":[26,53],"fully":[27],"explained":[28],"by":[29,131],"miRNA-mediated":[30],"targeted":[31],"transcript":[32],"degradation.":[33],"miRvestigator":[34,84,158,184],"takes":[35],"as":[36],"input":[37],"lists":[38],"co-expressed":[40],"genes":[41],"from":[42,102],"Caenorhabditis":[43],"elegans,":[44],"Drosophila":[45],"melanogaster,":[46],"G.":[47],"gallus,":[48],"Homo":[49],"sapiens,":[50],"Mus":[51],"musculus":[52],"Rattus":[54],"norvegicus":[55],"and":[56,148],"identifies":[57],"the":[58,74,83,103,114,117,129,157,173,178],"specific":[59],"miRNAs":[60],"that":[61],"are":[62],"likely":[63],"to":[64,66,72,107,128,176],"bind":[65],"3'":[67],"un-translated":[68],"region":[69],"(UTR)":[70],"sequences":[71,147],"mediate":[73],"observed":[75],"co-regulation.":[76],"The":[77,183],"novelty":[78],"our":[80,133],"approach":[81],"is":[82,185],"hidden":[85],"Markov":[86],"model":[87],"(HMM)":[88],"algorithm":[89,135,139],"which":[90],"systematically":[91],"computes":[92],"similarity":[94],"P-value":[95],"each":[97],"unique":[98],"miRNA":[99,104,124,145,167],"seed":[100,146],"sequence":[101,110],"database":[105],"miRBase":[106],"an":[108],"overrepresented":[109],"motif":[111],"identified":[112],"within":[113,170],"3'-UTR":[115],"query":[118,174],"genes.":[119],"We":[120],"made":[122],"this":[123],"discovery":[125,143],"tool":[126],"accessible":[127],"community":[130],"integrating":[132],"HMM":[134],"with":[136],"proven":[138],"de":[141],"novo":[142],"wrapping":[149],"algorithms":[151],"into":[152],"user-friendly":[154],"interface.":[155],"Additionally,":[156],"web":[159],"server":[160],"also":[161],"produces":[162],"list":[164],"putative":[166],"binding":[168],"sites":[169],"3'-UTRs":[171],"transcripts":[175],"facilitate":[177],"design":[179],"validation":[181],"experiments.":[182],"freely":[186],"available":[187],"at":[188],"http://mirvestigator.systemsbiology.net.":[189]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}