{"id":"https://openalex.org/W2000982014","doi":"https://doi.org/10.1093/nar/gkr1149","title":"A comprehensive manually curated protein\u2013protein interaction database for the Death Domain superfamily","display_name":"A comprehensive manually curated protein\u2013protein interaction database for the Death Domain superfamily","publication_year":2011,"publication_date":"2011-11-30","ids":{"openalex":"https://openalex.org/W2000982014","doi":"https://doi.org/10.1093/nar/gkr1149","mag":"2000982014","pmid":"https://pubmed.ncbi.nlm.nih.gov/22135292"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkr1149","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr1149","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D331/16955152/gkr1149.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/40/D1/D331/16955152/gkr1149.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091215067","display_name":"Dongseop Kwon","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dongseop Kwon","raw_affiliation_strings":["Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113566471","display_name":"Jong Hwan Yoon","orcid":null},"institutions":[{"id":"https://openalex.org/I116631150","display_name":"Ulsan College","ror":"https://ror.org/02tec3785","country_code":"KR","type":"education","lineage":["https://openalex.org/I116631150"]},{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Hwan Yoon","raw_affiliation_strings":["Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","University of Ulsan, Ulsan, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I139264467","https://openalex.org/I116631150","https://openalex.org/I89440247"]},{"raw_affiliation_string":"University of Ulsan, Ulsan, South Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009019474","display_name":"Soo-Yong Shin","orcid":"https://orcid.org/0000-0002-2410-6120"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]},{"id":"https://openalex.org/I116631150","display_name":"Ulsan College","ror":"https://ror.org/02tec3785","country_code":"KR","type":"education","lineage":["https://openalex.org/I116631150"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Yong Shin","raw_affiliation_strings":["Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","University of Ulsan, Ulsan, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I139264467","https://openalex.org/I116631150","https://openalex.org/I89440247"]},{"raw_affiliation_string":"University of Ulsan, Ulsan, South Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062403991","display_name":"Taeho Jang","orcid":null},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I116631150","display_name":"Ulsan College","ror":"https://ror.org/02tec3785","country_code":"KR","type":"education","lineage":["https://openalex.org/I116631150"]},{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Ho Jang","raw_affiliation_strings":["Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","University of Ulsan, Ulsan, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I139264467","https://openalex.org/I116631150","https://openalex.org/I89440247"]},{"raw_affiliation_string":"University of Ulsan, Ulsan, South Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058110900","display_name":"Hong\u2010Gee Kim","orcid":"https://orcid.org/0000-0002-2610-4321"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I116631150","display_name":"Ulsan College","ror":"https://ror.org/02tec3785","country_code":"KR","type":"education","lineage":["https://openalex.org/I116631150"]},{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hong-Gee Kim","raw_affiliation_strings":["Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","University of Ulsan, Ulsan, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I139264467","https://openalex.org/I116631150","https://openalex.org/I89440247"]},{"raw_affiliation_string":"University of Ulsan, Ulsan, South Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077653549","display_name":"Insuk So","orcid":"https://orcid.org/0000-0003-2294-2050"},"institutions":[{"id":"https://openalex.org/I116631150","display_name":"Ulsan College","ror":"https://ror.org/02tec3785","country_code":"KR","type":"education","lineage":["https://openalex.org/I116631150"]},{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Insuk So","raw_affiliation_strings":["Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","University of Ulsan, Ulsan, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Myongji University, Gyeonggi-do 449-728, 2Department of Biotechnology, Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, 712-749, 3Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine and Asan Medical Center, Seoul 135-798, 4Biomedical Knowledge Engineering Laboratory, Seoul National University and 5Department of Physiology, Seoul National University College of Medicine, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, 110-799, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001","https://openalex.org/I139264467","https://openalex.org/I116631150","https://openalex.org/I89440247"]},{"raw_affiliation_string":"University of Ulsan, Ulsan, South Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023662947","display_name":"Ju\u2010Hong Jeon","orcid":"https://orcid.org/0000-0002-5603-2955"},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju-Hong Jeon","raw_affiliation_strings":["University of Ulsan, Ulsan, South Korea"],"affiliations":[{"raw_affiliation_string":"University of Ulsan, Ulsan, South Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022716093","display_name":"Hyun Ho Park","orcid":"https://orcid.org/0000-0001-9928-0847"},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Ho Park","raw_affiliation_strings":["University of Ulsan, Ulsan, South Korea"],"affiliations":[{"raw_affiliation_string":"University of Ulsan, Ulsan, South Korea","institution_ids":["https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5091215067"],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.4675,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.80728686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"40","issue":"D1","first_page":"D331","last_page":"D336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7633540630340576},{"id":"https://openalex.org/keywords/superfamily","display_name":"SUPERFAMILY","score":0.7379067540168762},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.5995968580245972},{"id":"https://openalex.org/keywords/immunoglobulin-superfamily","display_name":"Immunoglobulin superfamily","score":0.5789652466773987},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4770497679710388},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.448230504989624},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.43829208612442017},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3044728934764862},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.17235922813415527},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16216972470283508}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7633540630340576},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.7379067540168762},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.5995968580245972},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.5789652466773987},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4770497679710388},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.448230504989624},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.43829208612442017},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3044728934764862},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17235922813415527},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16216972470283508}],"mesh":[{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053418","descriptor_name":"Death Domain Receptor Signaling Adaptor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053418","descriptor_name":"Death Domain Receptor Signaling Adaptor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053418","descriptor_name":"Death Domain Receptor Signaling Adaptor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053418","descriptor_name":"Death Domain Receptor Signaling Adaptor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053418","descriptor_name":"Death Domain Receptor Signaling Adaptor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053418","descriptor_name":"Death Domain Receptor Signaling Adaptor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkr1149","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr1149","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D331/16955152/gkr1149.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:22135292","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22135292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:nar:40/D1/D331","is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/40/D1/D331","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:3245059","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245059","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkr1149","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr1149","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D331/16955152/gkr1149.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000982014.pdf","grobid_xml":"https://content.openalex.org/works/W2000982014.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W168574213","https://openalex.org/W1529674879","https://openalex.org/W1573146315","https://openalex.org/W1965971815","https://openalex.org/W1986308149","https://openalex.org/W1993211211","https://openalex.org/W1997637712","https://openalex.org/W2001969264","https://openalex.org/W2006929002","https://openalex.org/W2008515134","https://openalex.org/W2012453730","https://openalex.org/W2013052118","https://openalex.org/W2016088798","https://openalex.org/W2022569128","https://openalex.org/W2056169996","https://openalex.org/W2057545775","https://openalex.org/W2067230454","https://openalex.org/W2078369696","https://openalex.org/W2106391842","https://openalex.org/W2107580398","https://openalex.org/W2130687290","https://openalex.org/W2131653304","https://openalex.org/W2132262177","https://openalex.org/W2167340762","https://openalex.org/W2772934464","https://openalex.org/W2916767477","https://openalex.org/W2917375902","https://openalex.org/W4211208250"],"related_works":["https://openalex.org/W2016714431","https://openalex.org/W2080549723","https://openalex.org/W2219408394","https://openalex.org/W4230567045","https://openalex.org/W1982442998","https://openalex.org/W2023430158","https://openalex.org/W2060687897","https://openalex.org/W4239797724","https://openalex.org/W2975240829","https://openalex.org/W2055148632"],"abstract_inverted_index":{"The":[0,108,138],"Death":[1],"Domain":[2],"(DD)":[3],"superfamily,":[4],"which":[5,72],"is":[6,76,160,191],"one":[7],"of":[8,12,57,67,104,145],"the":[9,51,65,68,73,86,105,123,125,133,146,163,187,194],"largest":[10],"classes":[11],"protein":[13],"interaction":[14],"modules,":[15],"plays":[16],"a":[17,90,142,177],"pivotal":[18],"role":[19],"in":[20,53,122,162,185],"apoptosis,":[21],"inflammation,":[22],"necrosis":[23],"and":[24,48,60,80,150,171,179],"immune":[25],"cell":[26],"signaling":[27,35,188],"pathways.":[28],"Because":[29],"aberrant":[30],"or":[31],"inappropriate":[32],"DD":[33,74,87,106,109,135,139,147,195],"superfamily-mediated":[34],"events":[36],"are":[37,56],"associated":[38,77],"with":[39,78],"various":[40],"human":[41],"diseases,":[42],"such":[43],"as":[44],"cancers,":[45],"neurodegenerative":[46],"diseases":[47],"immunological":[49],"disorders,":[50],"studies":[52,118],"these":[54],"fields":[55],"great":[58],"biological":[59,79],"clinical":[61],"importance.":[62],"To":[63],"facilitate":[64],"understanding":[66,186],"molecular":[69],"mechanisms":[70],"by":[71,113,193],"superfamily":[75,136,148],"disease":[81],"processes,":[82],"we":[83],"have":[84],"developed":[85],"database":[88,93,110,140,175],"(http://www.deathdomain.org),":[89],"manually":[91,114],"curated":[92],"that":[94,119,159,182,190],"aims":[95],"to":[96],"offer":[97],"comprehensive":[98],"information":[99,158],"on":[100,165],"protein-protein":[101],"interactions":[102],"(PPIs)":[103],"superfamily.":[107,196],"was":[111],"created":[112],"curating":[115],"295":[116],"peer-reviewed":[117],"were":[120],"published":[121],"literature;":[124],"current":[126],"version":[127],"documents":[128],"175":[129],"PPI":[130,152],"pairs":[131],"among":[132],"99":[134],"proteins.":[137],"provides":[141,176],"detailed":[143],"summary":[144],"proteins":[149],"their":[151],"data.":[153],"Users":[154],"can":[155],"find":[156],"in-depth":[157],"specified":[161],"literature":[164],"relevant":[166],"analytical":[167],"methods,":[168],"experimental":[169],"resources":[170],"domain":[172],"structures.":[173],"Our":[174],"definitive":[178],"valuable":[180],"tool":[181],"assists":[183],"researchers":[184],"network":[189],"mediated":[192]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}