{"id":"https://openalex.org/W2108723491","doi":"https://doi.org/10.1093/nar/gkr1126","title":"Rhea\u2014a manually curated resource of biochemical reactions","display_name":"Rhea\u2014a manually curated resource of biochemical reactions","publication_year":2011,"publication_date":"2011-11-30","ids":{"openalex":"https://openalex.org/W2108723491","doi":"https://doi.org/10.1093/nar/gkr1126","mag":"2108723491","pmid":"https://pubmed.ncbi.nlm.nih.gov/22135291"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkr1126","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr1126","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D754/16954810/gkr1126.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/40/D1/D754/16954810/gkr1126.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084595579","display_name":"Rafael Alc\u00e1ntara","orcid":"https://orcid.org/0000-0001-5152-9922"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["CH","GB"],"is_corresponding":false,"raw_author_name":"Rafael Alc\u00e1ntara","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK. rafael.alcantara@ebi.ac.uk","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK. rafael.alcantara@ebi.ac.uk","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077863600","display_name":"Kristian B. Axelsen","orcid":"https://orcid.org/0000-0003-3889-2879"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Kristian B. Axelsen","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091324355","display_name":"Anne Morgat","orcid":"https://orcid.org/0000-0002-1216-2969"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Anne Morgat","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","BAMBOO - An algorithmic view on genomes, cells, and environments (Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive. UMR CNRS 5558 Campus de La Doua - Universit\u00e9 Claude Bernard - Lyon 1 B\u00e2timent Gr\u00e9goire Mendel - 16 rue Raphael Dubois 69 100 Villeurbanne -- INRIA Grenoble - Rh\u00f4ne-Alpes Inovall\u00e9e 655 avenue de l'Europe -Montbonnot 38 334 Saint Ismier Cedex France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"BAMBOO - An algorithmic view on genomes, cells, and environments (Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive. UMR CNRS 5558 Campus de La Doua - Universit\u00e9 Claude Bernard - Lyon 1 B\u00e2timent Gr\u00e9goire Mendel - 16 rue Raphael Dubois 69 100 Villeurbanne -- INRIA Grenoble - Rh\u00f4ne-Alpes Inovall\u00e9e 655 avenue de l'Europe -Montbonnot 38 334 Saint Ismier Cedex France - France)","institution_ids":["https://openalex.org/I4210135640","https://openalex.org/I1326498283","https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056937785","display_name":"Eugeni Belda","orcid":"https://orcid.org/0000-0003-4307-5072"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Eugeni Belda","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089027967","display_name":"Elisabeth Coudert","orcid":"https://orcid.org/0000-0001-8314-404X"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Elisabeth Coudert","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090916579","display_name":"Alan Bridge","orcid":"https://orcid.org/0000-0003-2148-9135"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Alan Bridge","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101971891","display_name":"Hong Cao","orcid":"https://orcid.org/0000-0002-3793-6844"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Hong Cao","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064115359","display_name":"Paula de Matos","orcid":null},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Paula de Matos","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002211213","display_name":"Marcus Ennis","orcid":"https://orcid.org/0000-0002-6580-6297"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Marcus Ennis","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023586294","display_name":"Steve Turner","orcid":"https://orcid.org/0000-0001-8393-5060"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Steve Turner","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","Department of Clinical Biochemistry (SAS Laboratory Department of Clinical Biochemistry Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP - United Kingdom)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Department of Clinical Biochemistry (SAS Laboratory Department of Clinical Biochemistry Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP - United Kingdom)","institution_ids":["https://openalex.org/I2800516725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031305148","display_name":"Gareth Owen","orcid":"https://orcid.org/0000-0001-7265-5776"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Gareth Owen","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064539883","display_name":"Lydie Bougueleret","orcid":null},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Lydie Bougueleret","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065825020","display_name":"Ioannis X\u00e9narios","orcid":"https://orcid.org/0000-0002-3413-6841"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Ioannis Xenarios","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040194803","display_name":"Christoph Steinbeck","orcid":"https://orcid.org/0000-0001-6966-0814"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I3020098449","display_name":"CEA Grenoble","ror":"https://ror.org/02mg6n827","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I3020098449"]}],"countries":["CH","FR","GB"],"is_corresponding":false,"raw_author_name":"Christoph Steinbeck","raw_affiliation_strings":["Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemoinformatics and Metabolism Team, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland, 3Equipe BAMBOO, INRIA Grenoble Rh\u00f4ne-Alpes, 655 avenue de l'Europe, F-38330 Montbonnot Saint-Martin, France, 4Genoscope\u2014LABGeM, CEA, 2 Rue Gaston Cr\u00e9mieux, CP 5706, F-91057 Evry, France and 5Vital-IT, Swiss Institute of Bioinformatics, Quartier Sorge, B\u00e2timent G\u00e9nopode, CH-1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1303153112","https://openalex.org/I3020098449","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.5927,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.93730404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"40","issue":"D1","first_page":"D754","last_page":"D760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7448064088821411},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.632375955581665},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5258890986442566},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.4832397401332855},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.44148558378219604},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.41542863845825195},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34014928340911865},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09743908047676086}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7448064088821411},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.632375955581665},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5258890986442566},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.4832397401332855},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.44148558378219604},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.41542863845825195},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34014928340911865},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09743908047676086},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gkr1126","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr1126","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D754/16954810/gkr1126.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:22135291","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22135291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:serval.unil.ch:BIB_E9A04015506E","is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_E9A04015506E","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research, vol. 40, no. Database issue, pp. D754-D760","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:iris.unil.ch:iris/243043","is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/243043","pdf_url":"https://iris.unil.ch/bitstreams/3f59ebbb-2650-429b-9e19-fe4dc86bab93/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:HAL:hal-00746861v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-00746861","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Research, 2012, 40 (Database issue), pp.D754-60. ⟨10.1093/nar/gkr1126⟩","raw_type":"Journal articles"},{"id":"pmh:oai:open-archive.highwire.org:nar:40/D1/D754","is_oa":false,"landing_page_url":"http://nar.oxfordjournals.org/cgi/content/short/40/D1/D754","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:3245052","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245052","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkr1126","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkr1126","pdf_url":"https://academic.oup.com/nar/article-pdf/40/D1/D754/16954810/gkr1126.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2618860244","display_name":null,"funder_award_id":"226073","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7257051450","display_name":"The Microme Project: A Knowledge-Based Bioinformatics Framework for Microbial Pathway Genomics","funder_award_id":"222886","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320313288","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52"},{"id":"https://openalex.org/F4320314023","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108723491.pdf"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W138570049","https://openalex.org/W603324113","https://openalex.org/W1806297117","https://openalex.org/W1946933859","https://openalex.org/W1969709265","https://openalex.org/W1984602113","https://openalex.org/W1985512202","https://openalex.org/W1995860742","https://openalex.org/W2002635898","https://openalex.org/W2029657049","https://openalex.org/W2034504949","https://openalex.org/W2051810242","https://openalex.org/W2058673890","https://openalex.org/W2068526246","https://openalex.org/W2085945924","https://openalex.org/W2098609989","https://openalex.org/W2099389777","https://openalex.org/W2104295259","https://openalex.org/W2110679449","https://openalex.org/W2111973517","https://openalex.org/W2125904022","https://openalex.org/W2126175129","https://openalex.org/W2128601422","https://openalex.org/W2139915240","https://openalex.org/W2140808721","https://openalex.org/W2171437346","https://openalex.org/W2612240612","https://openalex.org/W4229667908","https://openalex.org/W4233060585","https://openalex.org/W4244806755","https://openalex.org/W4251203608","https://openalex.org/W6637986004"],"related_works":["https://openalex.org/W2003333417","https://openalex.org/W2055243143","https://openalex.org/W2378862226","https://openalex.org/W118236634","https://openalex.org/W2355326633","https://openalex.org/W2804669904","https://openalex.org/W2149777447","https://openalex.org/W2171305205","https://openalex.org/W2786774244","https://openalex.org/W2005673176"],"abstract_inverted_index":{"Rhea":[0,10,33,49],"(http://www.ebi.ac.uk/rhea)":[1],"is":[2,110],"a":[3,12,21,111],"comprehensive":[4],"resource":[5],"of":[6,15,24,60,101,118],"expert-curated":[7],"biochemical":[8],"reactions.":[9,48],"provides":[11],"non-redundant":[13],"set":[14],"chemical":[16,54],"transformations":[17],"for":[18,69],"use":[19],"in":[20,115],"broad":[22],"spectrum":[23],"applications,":[25],"including":[26,89],"metabolic":[27,121],"network":[28],"reconstruction":[29,117],"and":[30,45,65,71,83,91,99,104,123],"pathway":[31,92],"inference.":[32],"includes":[34],"enzyme-catalyzed":[35],"reactions":[36,44,50,103],"(covering":[37],"the":[38,57,97,116],"IUBMB":[39],"Enzyme":[40],"Nomenclature":[41],"list),":[42],"transport":[43],"spontaneously":[46],"occurring":[47],"are":[51,66,74],"described":[52],"using":[53],"species":[55],"from":[56],"Chemical":[58],"Entities":[59],"Biological":[61],"Interest":[62],"ontology":[63],"(ChEBI)":[64],"stoichiometrically":[67],"balanced":[68],"mass":[70],"charge.":[72],"They":[73],"extensively":[75],"manually":[76],"curated":[77],"with":[78],"links":[79],"to":[80],"source":[81],"literature":[82],"other":[84],"public":[85],"resources":[86],"on":[87],"metabolism":[88],"enzyme":[90],"databases.":[93],"This":[94],"cross-referencing":[95],"facilitates":[96],"mapping":[98],"reconciliation":[100],"common":[102,112],"compounds":[105],"between":[106],"distinct":[107],"resources,":[108],"which":[109],"first":[113],"step":[114],"genome":[119],"scale":[120],"networks":[122],"models.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}