{"id":"https://openalex.org/W2102687634","doi":"https://doi.org/10.1093/nar/gkq1100","title":"PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins","display_name":"PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins","publication_year":2010,"publication_date":"2010-11-08","ids":{"openalex":"https://openalex.org/W2102687634","doi":"https://doi.org/10.1093/nar/gkq1100","mag":"2102687634","pmid":"https://pubmed.ncbi.nlm.nih.gov/21059684"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkq1100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq1100","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkq1100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109191910","display_name":"Abel L. Robertson","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. L. Robertson","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091107125","display_name":"Mark A. Bate","orcid":null},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. A. Bate","raw_affiliation_strings":["The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia"],"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082930735","display_name":"George Androulakis","orcid":"https://orcid.org/0000-0001-6369-2348"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. G. Androulakis","raw_affiliation_strings":["The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia"],"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088390473","display_name":"Stephen Bottomley","orcid":null},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. P. Bottomley","raw_affiliation_strings":["The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia"],"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031275115","display_name":"Ashley M. Buckle","orcid":"https://orcid.org/0000-0003-2943-9044"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. M. Buckle","raw_affiliation_strings":["The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia"],"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences and 2 Monash eResearch Centre, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5109191910"],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.0611,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.73600254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"39","issue":"Database","first_page":"D272","last_page":"D276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8149586915969849},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.7295910716056824},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.560443639755249},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5363176465034485},{"id":"https://openalex.org/keywords/architecture-domain","display_name":"Architecture domain","score":0.5042904615402222},{"id":"https://openalex.org/keywords/glutamine","display_name":"Glutamine","score":0.4634115397930145},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.4513224959373474},{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.4507078528404236},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4490151107311249},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44142961502075195},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.41750872135162354},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4172728955745697},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.27343133091926575},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2616775631904602},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17546123266220093}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8149586915969849},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7295910716056824},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.560443639755249},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5363176465034485},{"id":"https://openalex.org/C194167682","wikidata":"https://www.wikidata.org/wiki/Q4787088","display_name":"Architecture domain","level":5,"score":0.5042904615402222},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.4634115397930145},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4513224959373474},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.4507078528404236},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4490151107311249},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44142961502075195},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.41750872135162354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4172728955745697},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.27343133091926575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2616775631904602},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17546123266220093},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C163352659","wikidata":"https://www.wikidata.org/wiki/Q5380367","display_name":"Enterprise architecture management","level":4,"score":0.0},{"id":"https://openalex.org/C10590034","wikidata":"https://www.wikidata.org/wiki/Q1048431","display_name":"Enterprise architecture","level":3,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gkq1100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq1100","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:21059684","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21059684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.292.4973","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.4973","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ed/2c/Nucleic_Acids_Res_2011_Jan_8_39(Database_issue)_D272-D276.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.860.9205","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.860.9205","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/39/suppl_1/D272.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.862.26","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.862.26","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2010/11/07/nar.gkq1100.full.pdf","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3013692","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3013692","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkq1100","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq1100","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1978124503","https://openalex.org/W1985474993","https://openalex.org/W1986075313","https://openalex.org/W1988110501","https://openalex.org/W2015324688","https://openalex.org/W2030985020","https://openalex.org/W2032255653","https://openalex.org/W2037126504","https://openalex.org/W2041376177","https://openalex.org/W2053780937","https://openalex.org/W2055043387","https://openalex.org/W2070682368","https://openalex.org/W2073156864","https://openalex.org/W2077449710","https://openalex.org/W2079771002","https://openalex.org/W2085707879","https://openalex.org/W2088661320","https://openalex.org/W2091028658","https://openalex.org/W2097704427","https://openalex.org/W2115396351","https://openalex.org/W2120717592","https://openalex.org/W2124166542","https://openalex.org/W2128653811","https://openalex.org/W2130479394","https://openalex.org/W2141885858","https://openalex.org/W2163895365","https://openalex.org/W4210623056","https://openalex.org/W4236236547"],"related_works":["https://openalex.org/W24553703","https://openalex.org/W4211000692","https://openalex.org/W4212920271","https://openalex.org/W4211054902","https://openalex.org/W2612240612","https://openalex.org/W2068850418","https://openalex.org/W2079036660","https://openalex.org/W1984316389","https://openalex.org/W2102856132","https://openalex.org/W1696121626"],"abstract_inverted_index":{"The":[0],"polyglutamine":[1,111],"diseases":[2],"are":[3],"caused":[4],"in":[5,20,113],"part":[6],"by":[7],"a":[8,73],"gain-of-function":[9],"mechanism":[10,35],"of":[11,25,41,51,65,68,82,88,110],"neuronal":[12],"toxicity":[13],"involving":[14],"protein":[15],"conformational":[16],"changes":[17],"that":[18,32,39,106],"result":[19],"the":[21,33,42,46,52,62,66,80,107],"formation":[22],"and":[23,38,49,94,115],"deposition":[24],"\u03b2-sheet":[26],"rich":[27],"aggregates.":[28],"Recent":[29],"evidence":[30],"suggests":[31],"misfolding":[34],"is":[36],"context-dependent,":[37],"properties":[40],"host":[43],"protein,":[44],"including":[45],"domain":[47,99],"architecture":[48],"location":[50],"repeat":[53],"tract,":[54],"can":[55,102,119],"modulate":[56],"aggregation.":[57],"In":[58],"order":[59],"to":[60],"allow":[61],"bioinformatic":[63],"investigation":[64],"context":[67,109],"polyglutamines,":[69],"we":[70],"have":[71,78],"constructed":[72],"database,":[74],"PolyQ":[75,101],"(http://pxgrid.med.monash.edu.au/polyq).":[76],"We":[77],"collected":[79],"sequences":[81,97],"all":[83],"human":[84],"proteins":[85,118],"containing":[86],"runs":[87],"seven":[89],"or":[90],"more":[91],"glutamine":[92],"residues":[93],"annotated":[95],"their":[96],"with":[98],"information.":[100],"be":[103,120],"interrogated":[104],"such":[105],"sequence":[108],"repeats":[112],"disease":[114],"non-disease":[116],"associated":[117],"investigated.":[121]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}