{"id":"https://openalex.org/W2009081245","doi":"https://doi.org/10.1093/nar/gkq1037","title":"PROMISCUOUS: a database for network-based drug-repositioning","display_name":"PROMISCUOUS: a database for network-based drug-repositioning","publication_year":2010,"publication_date":"2010-11-10","ids":{"openalex":"https://openalex.org/W2009081245","doi":"https://doi.org/10.1093/nar/gkq1037","mag":"2009081245"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkq1037","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq1037","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkq1037","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011094483","display_name":"Joachim von Eichborn","orcid":null},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. von Eichborn","raw_affiliation_strings":["University of Montana, Missoula, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montana, Missoula, United States","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012962252","display_name":"Manuela S. Murgueitio","orcid":null},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. S. Murgueitio","raw_affiliation_strings":["University of Montana, Missoula, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montana, Missoula, United States","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090164972","display_name":"Mathias Dunkel","orcid":"https://orcid.org/0000-0002-6642-483X"},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Dunkel","raw_affiliation_strings":["University of Montana, Missoula, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montana, Missoula, United States","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029624778","display_name":"S. Koerner","orcid":null},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Koerner","raw_affiliation_strings":["University of Montana, Missoula, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montana, Missoula, United States","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075833022","display_name":"Philip E. Bourne","orcid":"https://orcid.org/0000-0002-7618-7292"},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. E. Bourne","raw_affiliation_strings":["University of Montana, Missoula, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montana, Missoula, United States","institution_ids":["https://openalex.org/I6750721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043414157","display_name":"Robert Prei\u00dfner","orcid":"https://orcid.org/0000-0002-2407-1087"},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Preissner","raw_affiliation_strings":["University of Montana, Missoula, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Montana, Missoula, United States","institution_ids":["https://openalex.org/I6750721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":19.9254,"has_fulltext":false,"cited_by_count":227,"citation_normalized_percentile":{"value":0.99626548,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"39","issue":"Database","first_page":"D1060","last_page":"D1066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.7607229948043823},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6550440788269043},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5602662563323975},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4995577335357666},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4610542356967926},{"id":"https://openalex.org/keywords/data-curation","display_name":"Data curation","score":0.4555247724056244},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.44286757707595825},{"id":"https://openalex.org/keywords/approved-drug","display_name":"Approved drug","score":0.4272226095199585},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.368476927280426},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3413093090057373},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3406539857387543},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.33807671070098877},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2059262990951538}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.7607229948043823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6550440788269043},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5602662563323975},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4995577335357666},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4610542356967926},{"id":"https://openalex.org/C91632574","wikidata":"https://www.wikidata.org/wiki/Q15088675","display_name":"Data curation","level":2,"score":0.4555247724056244},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.44286757707595825},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.4272226095199585},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.368476927280426},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3413093090057373},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3406539857387543},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.33807671070098877},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2059262990951538},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkq1037","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq1037","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.986.8653","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.986.8653","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/early/2010/11/10/nar.gkq1037.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.992.8655","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.992.8655","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/39/suppl_1/D1060.full.pdf","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3013657","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3013657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkq1037","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq1037","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1480355062","https://openalex.org/W1504533062","https://openalex.org/W1527781663","https://openalex.org/W1895993106","https://openalex.org/W2002915579","https://openalex.org/W2009313526","https://openalex.org/W2062941476","https://openalex.org/W2074192927","https://openalex.org/W2076764146","https://openalex.org/W2098767742","https://openalex.org/W2108069034","https://openalex.org/W2130479394","https://openalex.org/W2138512826","https://openalex.org/W2139694010","https://openalex.org/W2140049079","https://openalex.org/W2142572836","https://openalex.org/W2147405665","https://openalex.org/W2147706313","https://openalex.org/W2148043260","https://openalex.org/W2150065588","https://openalex.org/W2150700412","https://openalex.org/W2151014102","https://openalex.org/W2154896031","https://openalex.org/W2156779720","https://openalex.org/W2159675211","https://openalex.org/W2165674132","https://openalex.org/W2166209362","https://openalex.org/W2269084602","https://openalex.org/W2408940827","https://openalex.org/W2469884426","https://openalex.org/W2772934464","https://openalex.org/W4211208250","https://openalex.org/W4243885716"],"related_works":["https://openalex.org/W4220885170","https://openalex.org/W4285506882","https://openalex.org/W3044296243","https://openalex.org/W3134564766","https://openalex.org/W2561827752","https://openalex.org/W4281726759","https://openalex.org/W4376478588","https://openalex.org/W2299074827","https://openalex.org/W4318481850","https://openalex.org/W3159848998"],"abstract_inverted_index":{"The":[0],"procedure":[1],"of":[2,14,32,45,56,65,96],"drug":[3],"approval":[4],"is":[5,37,132],"time-consuming,":[6],"costly":[7],"and":[8,43,77,89,115],"risky.":[9],"Accidental":[10],"findings":[11],"regarding":[12],"multi-specificity":[13],"approved":[15],"drugs":[16,36,66,100],"led":[17],"to":[18,53,110,113],"block-busters":[19],"in":[20,27],"new":[21,30],"indication":[22],"areas.":[23],"Therefore,":[24],"the":[25,40,54],"interest":[26],"systematically":[28],"elucidating":[29],"areas":[31],"application":[33],"for":[34,99,119,129],"known":[35,104],"rising.":[38],"Furthermore,":[39],"know-ledge,":[41],"understanding":[42,55],"prediction":[44],"so-called":[46],"off-target":[47],"effects":[48],"allow":[49],"a":[50,126],"rational":[51],"approach":[52,123],"side-effects.":[57],"With":[58],"PROMISCUOUS":[59,131],"we":[60],"provide":[61,125],"an":[62],"exhaustive":[63],"set":[64],"(25":[67],"000),":[68],"including":[69,92],"withdrawn":[70],"or":[71],"experimental":[72],"drugs,":[73],"anno-tated":[74],"with":[75],"drug\u2013protein":[76],"protein\u2013protein":[78,111],"rela-tionships":[79],"(21":[80],"500/104":[81],"000)":[82],"compiled":[83],"from":[84],"public":[85],"resources":[86],"via":[87],"text":[88],"data":[90],"mining":[91],"manual":[93],"curation.":[94],"Measures":[95],"structural":[97],"similarity":[98],"as":[101,103],"well":[102],"side-effects":[105],"can":[106,124],"be":[107],"easily":[108],"connected":[109],"interactions":[112],"establish":[114],"analyse":[116],"networks":[117],"responsible":[118],"multi-pharmacology.":[120],"This":[121],"network-based":[122],"starting":[127],"point":[128],"drug-repositioning.":[130],"publicly":[133],"available":[134],"at":[135]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":22}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}