{"id":"https://openalex.org/W2082899043","doi":"https://doi.org/10.1093/nar/gkp312","title":"SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical\u2013protein interactome","display_name":"SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical\u2013protein interactome","publication_year":2009,"publication_date":"2009-05-05","ids":{"openalex":"https://openalex.org/W2082899043","doi":"https://doi.org/10.1093/nar/gkp312","mag":"2082899043","pmid":"https://pubmed.ncbi.nlm.nih.gov/19417066"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkp312","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkp312","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_2/W406/16757869/gkp312.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/37/suppl_2/W406/16757869/gkp312.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102084645","display_name":"Lun Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lun Yang","raw_affiliation_strings":["Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China. lunyang@gmail.com","Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China"],"affiliations":[{"raw_affiliation_string":"Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China. lunyang@gmail.com","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047001057","display_name":"Heng Luo","orcid":"https://orcid.org/0000-0001-5192-8878"},"institutions":[{"id":"https://openalex.org/I4210123333","display_name":"Ministry of Education","ror":"https://ror.org/036nq5137","country_code":"TH","type":"government","lineage":["https://openalex.org/I4210123333"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN","TH"],"is_corresponding":false,"raw_author_name":"Heng Luo","raw_affiliation_strings":["Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030,","Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030,","institution_ids":["https://openalex.org/I4210123333"]},{"raw_affiliation_string":"Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326426","display_name":"Jian Chen","orcid":"https://orcid.org/0000-0002-0230-824X"},"institutions":[{"id":"https://openalex.org/I4210123333","display_name":"Ministry of Education","ror":"https://ror.org/036nq5137","country_code":"TH","type":"government","lineage":["https://openalex.org/I4210123333"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN","TH"],"is_corresponding":false,"raw_author_name":"Jian Chen","raw_affiliation_strings":["Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030,","Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032 and","Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030,","institution_ids":["https://openalex.org/I4210123333"]},{"raw_affiliation_string":"Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032 and","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004515455","display_name":"Qinghe Xing","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghe Xing","raw_affiliation_strings":["Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032 and","Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032 and","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102798483","display_name":"Lin He","orcid":"https://orcid.org/0000-0003-1079-1195"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin He","raw_affiliation_strings":["Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, PR China","Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032 and","Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, PR China","institution_ids":["https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032 and","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102084645"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":6.0345,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.96635623,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"37","issue":"suppl_2","first_page":"W406","last_page":"W412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.9491606950759888},{"id":"https://openalex.org/keywords/dock","display_name":"DOCK","score":0.7826874256134033},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7249027490615845},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6689077019691467},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.6319434642791748},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5106156468391418},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.49816036224365234},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.47889772057533264},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.47275716066360474},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.4610236585140228},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3920769989490509},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.322903037071228},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3069687485694885},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30307191610336304},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.18969368934631348},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.18712499737739563},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1765064299106598},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08901211619377136}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.9491606950759888},{"id":"https://openalex.org/C93073132","wikidata":"https://www.wikidata.org/wiki/Q24726581","display_name":"DOCK","level":2,"score":0.7826874256134033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7249027490615845},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6689077019691467},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.6319434642791748},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5106156468391418},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49816036224365234},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47889772057533264},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.47275716066360474},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.4610236585140228},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3920769989490509},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.322903037071228},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3069687485694885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30307191610336304},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.18969368934631348},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.18712499737739563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1765064299106598},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08901211619377136},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkp312","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkp312","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_2/W406/16757869/gkp312.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:19417066","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19417066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2703957","is_oa":true,"landing_page_url":"http://doi.org/10.1093/nar/gkp312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkp312","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkp312","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_2/W406/16757869/gkp312.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082899043.pdf","grobid_xml":"https://content.openalex.org/works/W2082899043.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1592950931","https://openalex.org/W1604013791","https://openalex.org/W1969130336","https://openalex.org/W1973174482","https://openalex.org/W1979947684","https://openalex.org/W1995968109","https://openalex.org/W1999614615","https://openalex.org/W2003984225","https://openalex.org/W2011787625","https://openalex.org/W2017701241","https://openalex.org/W2021077280","https://openalex.org/W2023889019","https://openalex.org/W2043696829","https://openalex.org/W2055147198","https://openalex.org/W2065954013","https://openalex.org/W2067304863","https://openalex.org/W2075455619","https://openalex.org/W2078653892","https://openalex.org/W2101661766","https://openalex.org/W2120289139","https://openalex.org/W2127125241","https://openalex.org/W2132629607","https://openalex.org/W2136144366","https://openalex.org/W2146404049","https://openalex.org/W2150043676","https://openalex.org/W2161062388","https://openalex.org/W2161821474","https://openalex.org/W2405309425","https://openalex.org/W2415618143","https://openalex.org/W2608516693","https://openalex.org/W4211000692","https://openalex.org/W4285719527","https://openalex.org/W6716521224"],"related_works":["https://openalex.org/W4282913408","https://openalex.org/W2100436540","https://openalex.org/W2300502530","https://openalex.org/W3201417569","https://openalex.org/W3033824302","https://openalex.org/W2070163817","https://openalex.org/W2091429460","https://openalex.org/W2102475066","https://openalex.org/W2395175315","https://openalex.org/W1938743025"],"abstract_inverted_index":{"Serious":[0],"adverse":[1],"drug":[2,41,90,200],"reactions":[3],"(SADRs)":[4],"are":[5,30],"caused":[6],"by":[7,61,162],"unexpected":[8],"drug-human":[9],"protein":[10],"interactions,":[11],"and":[12,51,164],"some":[13],"polymorphisms":[14,23],"within":[15],"binding":[16,152,172],"pockets":[17],"make":[18],"the":[19,62,77,83,94,106,119,126,151,155,171,174,185,195],"population":[20],"carrying":[21],"these":[22],"susceptible":[24,34],"to":[25,32,35,48,193],"SADR.":[26],"Predicting":[27],"which":[28,117],"populations":[29,181],"likely":[31],"be":[33,189],"SADR":[36,86,139],"will":[37,44,188],"not":[38],"only":[39],"strengthen":[40],"safety,":[42],"but":[43],"also":[45,149],"assist":[46],"enterprises":[47],"adjust":[49],"R&D":[50],"marketing":[52],"strategies.":[53],"Making":[54],"such":[55],"predictions":[56],"has":[57,72],"recently":[58],"been":[59],"facilitated":[60],"introduction":[63],"of":[64,76,80,96,129,154,184,198],"a":[65,73,89,112,130],"web":[66],"server":[67,71,110,148,203],"named":[68],"SePreSA.":[69],"The":[70,109,147,202],"comprehensive":[74],"collection":[75],"structural":[78],"models":[79],"nearly":[81],"all":[82],"well":[84],"known":[85],"targets.":[87],"Once":[88],"molecule":[91],"is":[92,103,204],"submitted,":[93],"scale":[95],"its":[97],"potential":[98],"interaction":[99,122],"with":[100],"multi-SADR":[101],"targets":[102,140],"calculated":[104],"using":[105,143],"DOCK":[107],"program.":[108],"utilizes":[111],"2-directional":[113],"Z-transformation":[114],"scoring":[115,145],"algorithm,":[116],"computes":[118],"relative":[120],"drug-protein":[121],"strength":[123],"based":[124],"on":[125,173],"docking-score":[127],"matrix":[128],"chemical-protein":[131],"interactome,":[132],"thus":[133],"achieve":[134],"greater":[135],"accuracy":[136],"in":[137,170],"prioritizing":[138],"than":[141],"simply":[142],"dock":[144],"functions.":[146],"suggests":[150],"pattern":[153],"lowest":[156],"docking":[157],"score":[158],"through":[159],"3D":[160],"visualization,":[161],"highlighting":[163],"visualizing":[165],"amino":[166],"acid":[167],"residues":[168,187],"involved":[169],"customer's":[175],"browser.":[176],"Polymorphism":[177],"information":[178],"for":[179,182],"different":[180],"each":[183],"interactive":[186],"displayed,":[190],"helping":[191],"users":[192],"deduce":[194],"population-specific":[196],"susceptibility":[197],"their":[199],"molecule.":[201],"freely":[205],"available":[206],"at":[207],"http://SePreSA.Bio-X.cn/.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}