{"id":"https://openalex.org/W2149664004","doi":"https://doi.org/10.1093/nar/gkn817","title":"siRecords: a database of mammalian RNAi experiments and efficacies","display_name":"siRecords: a database of mammalian RNAi experiments and efficacies","publication_year":2008,"publication_date":"2008-11-08","ids":{"openalex":"https://openalex.org/W2149664004","doi":"https://doi.org/10.1093/nar/gkn817","mag":"2149664004","pmid":"https://pubmed.ncbi.nlm.nih.gov/18996894"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkn817","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn817","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D146/3299643/gkn817.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D146/3299643/gkn817.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078344464","display_name":"Yukun Ren","orcid":"https://orcid.org/0000-0002-0167-1274"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Ren","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037567740","display_name":"Wenbin Gong","orcid":"https://orcid.org/0000-0002-1699-9213"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Gong","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077384845","display_name":"Haiyan Zhou","orcid":"https://orcid.org/0000-0003-1569-532X"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Zhou","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371993","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0002-1211-2822"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Wang","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086844078","display_name":"Feifei Xiao","orcid":"https://orcid.org/0000-0002-1597-4719"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Xiao","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028227024","display_name":"T. Li","orcid":"https://orcid.org/0009-0005-2104-8235"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. Li","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028227024"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.1229,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.77649506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"37","issue":"Database","first_page":"D146","last_page":"D149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9534375071525574},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.6367233395576477},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46481049060821533},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4006458520889282},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.39986109733581543},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1808163821697235},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.16288131475448608},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07354146242141724}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9534375071525574},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6367233395576477},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46481049060821533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4006458520889282},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.39986109733581543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1808163821697235},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16288131475448608},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07354146242141724}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkn817","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn817","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D146/3299643/gkn817.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:18996894","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18996894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.614.7808","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.614.7808","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/37/suppl_1/D146.full-text-lowres.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.5285","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.5285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4c/6a/gkn817.PMC2686443.pdf","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2686443","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2686443","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkn817","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn817","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D146/3299643/gkn817.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1647075334","https://openalex.org/W1862697881","https://openalex.org/W1966759115","https://openalex.org/W1976060898","https://openalex.org/W1982304115","https://openalex.org/W1984006325","https://openalex.org/W1985486355","https://openalex.org/W1986687961","https://openalex.org/W1990252238","https://openalex.org/W1996164865","https://openalex.org/W2003507585","https://openalex.org/W2003722342","https://openalex.org/W2004981153","https://openalex.org/W2012188597","https://openalex.org/W2021310770","https://openalex.org/W2024399959","https://openalex.org/W2029052373","https://openalex.org/W2058627189","https://openalex.org/W2068205681","https://openalex.org/W2071596792","https://openalex.org/W2078187809","https://openalex.org/W2081570141","https://openalex.org/W2086579410","https://openalex.org/W2097261962","https://openalex.org/W2106082032","https://openalex.org/W2107235611","https://openalex.org/W2109609799","https://openalex.org/W2110455072","https://openalex.org/W2134653938","https://openalex.org/W2138386457","https://openalex.org/W2151392603","https://openalex.org/W2151432781","https://openalex.org/W2156061695","https://openalex.org/W2156293062","https://openalex.org/W2157078151","https://openalex.org/W2159268893","https://openalex.org/W2166802510","https://openalex.org/W2166915947","https://openalex.org/W2418464975"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2117258802","https://openalex.org/W4234157524"],"abstract_inverted_index":{"RNAi-based":[0],"gene-silencing":[1],"techniques":[2,32],"offer":[3],"a":[4,43,78],"fast":[5],"and":[6,37,54,80,96,126,134],"cost-effective":[7],"way":[8],"of":[9,30,62,83,140,146,151],"knocking":[10],"down":[11],"genes'":[12],"functions":[13],"in":[14,24,27,33],"an":[15,59],"easily":[16],"regulated":[17],"manner.":[18],"Exciting":[19],"progress":[20],"has":[21],"been":[22],"made":[23],"recent":[25],"years":[26],"the":[28,90,107,113,124,130,138,149],"application":[29],"these":[31],"basic":[34],"biomedical":[35],"research":[36],"therapeutic":[38],"development.":[39],"However,":[40],"it":[41,76],"remains":[42],"difficult":[44],"task":[45],"to":[46,103],"design":[47,101],"effective":[48],"siRNA":[49,84,100],"experiments":[50,65,132,154],"with":[51,66,106,123],"high":[52],"efficacy":[53,68,125],"specificity.":[55],"We":[56],"present":[57],"siRecords,":[58],"extensive":[60],"database":[61,71,114],"mammalian":[63],"RNAi":[64,93,117,153],"consistent":[67],"ratings.":[69],"This":[70,86],"serves":[72],"two":[73],"purposes.":[74],"First,":[75],"provides":[77],"large":[79],"diverse":[81,92],"dataset":[82,87],"experiments.":[85],"faithfully":[88],"represents":[89],"general,":[91],"experimental":[94,116],"practice,":[95],"allows":[97],"more":[98],"reliable":[99],"tools":[102],"be":[104],"developed":[105],"overfitting":[108],"problem":[109],"well":[110],"curbed.":[111],"Second,":[112],"helps":[115],"researchers":[118],"directly":[119],"by":[120],"providing":[121],"them":[122],"other":[127],"information":[128],"about":[129],"siRNAs":[131],"designed":[133],"conducted":[135],"previously":[136],"against":[137],"genes":[139],"their":[141],"interest.":[142],"The":[143],"current":[144],"release":[145],"siRecords":[147],"contains":[148],"records":[150],"17,192":[152],"targeting":[155],"5086":[156],"genes.":[157]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-05-19T21:40:30.786675","created_date":"2025-10-10T00:00:00"}