{"id":"https://openalex.org/W2116423958","doi":"https://doi.org/10.1093/nar/gkn785","title":"InterPro: the integrative protein signature database","display_name":"InterPro: the integrative protein signature database","publication_year":2008,"publication_date":"2008-10-21","ids":{"openalex":"https://openalex.org/W2116423958","doi":"https://doi.org/10.1093/nar/gkn785","mag":"2116423958","pmid":"https://pubmed.ncbi.nlm.nih.gov/18940856"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkn785","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn785","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D211/3287888/gkn785.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D211/3287888/gkn785.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035016058","display_name":"Sarah Hunter","orcid":"https://orcid.org/0000-0003-2453-0770"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":true,"raw_author_name":"S. Hunter","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. hunter@ebi.ac.uk","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. hunter@ebi.ac.uk","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066667859","display_name":"Rolf Apweiler","orcid":"https://orcid.org/0000-0001-7078-200X"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"R. Apweiler","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016694329","display_name":"Teresa K. Attwood","orcid":"https://orcid.org/0000-0003-2409-4235"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"T. K. Attwood","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069843378","display_name":"Amos Bairoch","orcid":"https://orcid.org/0000-0003-2826-6444"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"A. Bairoch","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059430118","display_name":"Alex Bateman","orcid":"https://orcid.org/0000-0002-6982-4660"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"A. Bateman","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004738893","display_name":"David Binns","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"D. Binns","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074309419","display_name":"Peer Bork","orcid":"https://orcid.org/0000-0002-2627-833X"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"P. Bork","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078238468","display_name":"Ujjwal Das","orcid":"https://orcid.org/0000-0001-9276-9068"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"U. Das","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024088874","display_name":"Louise C. Daugherty","orcid":"https://orcid.org/0000-0003-4546-6667"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"L. Daugherty","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033282810","display_name":"L. Duquenne","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"L. Duquenne","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104045098","display_name":"ROBERT FINN","orcid":"https://orcid.org/0000-0001-8626-2148"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"R. D. Finn","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064008781","display_name":"Julian Gough","orcid":"https://orcid.org/0000-0002-1965-4982"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"J. Gough","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027242690","display_name":"Daniel H. Haft","orcid":"https://orcid.org/0000-0001-8101-4938"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"D. Haft","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058665636","display_name":"Nicolas Hulo","orcid":"https://orcid.org/0000-0003-2640-636X"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"N. Hulo","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107849358","display_name":"Daniel Kahn","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"D. Kahn","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039796140","display_name":"Elizabeth A. Kelly","orcid":"https://orcid.org/0000-0001-7335-6698"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"E. Kelly","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032302491","display_name":"Aur\u00e9lie Laugraud","orcid":"https://orcid.org/0000-0002-5606-3428"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"A. Laugraud","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072645674","display_name":"Ivica Letuni\u0107","orcid":"https://orcid.org/0000-0003-3560-4288"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"I. Letunic","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077102508","display_name":"D. Lonsdale","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"D. Lonsdale","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018972787","display_name":"Rodrigo L\u00f3pez","orcid":"https://orcid.org/0000-0003-1256-7306"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"R. Lopez","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065747942","display_name":"Martin Madera","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"M. Madera","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007876912","display_name":"John Maslen","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"J. Maslen","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039756477","display_name":"Craig McAnulla","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"C. McAnulla","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076374033","display_name":"J. McDowall","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"J. McDowall","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024885643","display_name":"Jaina Mistry","orcid":"https://orcid.org/0000-0003-2479-5322"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"J. Mistry","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083616654","display_name":"Alex Mitchell","orcid":"https://orcid.org/0000-0001-8655-7966"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"A. Mitchell","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080377820","display_name":"Nicola Mulder","orcid":"https://orcid.org/0000-0003-4905-0941"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"N. Mulder","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005555412","display_name":"Darren A. Natale","orcid":"https://orcid.org/0000-0001-5809-9523"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"D. Natale","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005187760","display_name":"C. Orengo","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"C. Orengo","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076535941","display_name":"A. F. Quinn","orcid":"https://orcid.org/0000-0002-0596-7638"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"A. F. Quinn","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088953398","display_name":"J. D. Selengut","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"J. D. Selengut","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057507337","display_name":"Christian J A Sigrist","orcid":"https://orcid.org/0000-0002-4348-0070"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"C. J. A. Sigrist","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030007324","display_name":"Manjula Thimma","orcid":"https://orcid.org/0000-0002-1703-8780"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"M. Thimma","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016853551","display_name":"Paul D. Thomas","orcid":"https://orcid.org/0000-0002-9074-3507"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"P. D. Thomas","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002029117","display_name":"F. Valentin","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"F. Valentin","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067726490","display_name":"Derek A. Wilson","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"D. Wilson","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053761444","display_name":"Cathy Wu","orcid":"https://orcid.org/0000-0001-6379-8601"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"C. H. Wu","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070093541","display_name":"Corin Yeats","orcid":"https://orcid.org/0000-0003-0080-6242"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["CH","DE","FR","GB","US"],"is_corresponding":false,"raw_author_name":"C. Yeats","raw_affiliation_strings":["EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2 Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3 Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5 European Molecular Laboratory (EMBL), Heidelberg, Germany, 6 Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7 Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8 J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9 Computational Biology Unit, University of Cape Town, South Africa, 10 Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11 Department of Structural and Molecular Biology, University College London, London, UK, 12 Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13 MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I45129253"]},{"raw_affiliation_string":"EMBL Outstation European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, 2Faculty of Life Science and School of Computer Science, The University of Manchester, Manchester, UK, 3Swiss Institute of Bioinformatics (SIB), Geneva, Switzerland, 4The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 5European Molecular Laboratory (EMBL), Heidelberg, Germany, 6Pole Rhone-Alpins de BioInformatique (PRABI) and Laboratoire de Biom\u00e9trie et Biologie Evolutive, CNRS, INRIA, Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, Villeurbanne, France, 7Department of Computer Science, University of Bristol, Woodland Road, Bristol, UK, 8J. Craig Venter Institute (JCVI), Rockville, MD, 20850, USA, 9Computational Biology Unit, University of Cape Town, South Africa, 10Protein Information Resource (PIR), Georgetown University Medical Center, Washington, DC, USA, 11Department of Structural and Molecular Biology, University College London, London, UK, 12Evolutionary Systems Biology, SRI International, Menlo Park, CA, 94025-3493, USA and 13MRC Laboratory of Molecular Biology, Cambridge","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5035016058"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I12708293","https://openalex.org/I1294671590","https://openalex.org/I1303153112","https://openalex.org/I184565670","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I2802476451","https://openalex.org/I45129253"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":69.8997,"has_fulltext":true,"cited_by_count":2171,"citation_normalized_percentile":{"value":0.99979799,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"37","issue":"Database","first_page":"D211","last_page":"D215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.9340150952339172},{"id":"https://openalex.org/keywords/xml","display_name":"XML","score":0.680899977684021},{"id":"https://openalex.org/keywords/upload","display_name":"Upload","score":0.6341845393180847},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5067070126533508},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.503955066204071},{"id":"https://openalex.org/keywords/user-interface","display_name":"User interface","score":0.4788541793823242},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.4575147032737732},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.43152546882629395},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42714935541152954},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3276645243167877},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09925734996795654}],"concepts":[{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.9340150952339172},{"id":"https://openalex.org/C8797682","wikidata":"https://www.wikidata.org/wiki/Q2115","display_name":"XML","level":2,"score":0.680899977684021},{"id":"https://openalex.org/C71901391","wikidata":"https://www.wikidata.org/wiki/Q7126699","display_name":"Upload","level":2,"score":0.6341845393180847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5067070126533508},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.503955066204071},{"id":"https://openalex.org/C89505385","wikidata":"https://www.wikidata.org/wiki/Q47146","display_name":"User interface","level":2,"score":0.4788541793823242},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.4575147032737732},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.43152546882629395},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42714935541152954},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3276645243167877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09925734996795654},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55352822","wikidata":"https://www.wikidata.org/wiki/Q5558978","display_name":"Gibbs isotherm","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1093/nar/gkn785","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn785","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D211/3287888/gkn785.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:18940856","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18940856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:unige.ch:unige:19865","is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:19865","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0305-1048","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edoc.mdc-berlin.de:9777","is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/9777/1/9777oa.pdf","pdf_url":"http://edoc.mdc-berlin.de/9777/1/9777oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doc.rero.ch:294782","is_oa":false,"landing_page_url":"http://doc.rero.ch/record/294782/files/gkn785.pdf","pdf_url":"http://doc.rero.ch/record/294782/files/gkn785.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.585.3849","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.3849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/37/suppl_1/D211.full.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-01214141v1","is_oa":true,"landing_page_url":"https://hal.science/hal-01214141","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:168499","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/168499/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NUCLEIC ACIDS RES , 37 D211 - D215. (2009)","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/dbffdeb9-0122-43fb-aa3e-a52add00315a","is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/dbffdeb9-0122-43fb-aa3e-a52add00315a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/dbffdeb9-0122-43fb-aa3e-a52add00315a","is_oa":false,"landing_page_url":"https://www.research.manchester.ac.uk/portal/en/publications/interpro-the-integrative-protein-signature-database(dbffdeb9-0122-43fb-aa3e-a52add00315a).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/8264afc7-fd47-45b8-8e37-6cb2889e2288","is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/8264afc7-fd47-45b8-8e37-6cb2889e2288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hunter, S, Apweiler, R, Gough, J, Wilson, D, Daugherty, L, Mandera, M & Mulder, N 2009, 'InterPro: the integrative protein signature database', Nucleic Acids Research, vol. 37, D211-D215. < http://www.cs.bris.ac.uk/Publications/pub_master.jsp?id=2000968 >","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkn785","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn785","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D211/3287888/gkn785.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.5799999833106995}],"awards":[{"id":"https://openalex.org/G1830477443","display_name":null,"funder_award_id":"BB/F010508/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6510465858","display_name":null,"funder_award_id":"GM081084","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6955215639","display_name":null,"funder_award_id":"BB/F010435/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7203045746","display_name":"Embracing new technologies to streamline improve and sustain InterPro and its contributing databases","funder_award_id":"BB/F010508/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7389578636","display_name":"IMproving Protein Annotation and Co-ordination through Technology","funder_award_id":"213037","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8039298099","display_name":"Embracing new technologies to streamline improve and sustain InterPro and its contributing databases","funder_award_id":"BB/F010435/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G822217490","display_name":"Integration of the Pfam database and recent HHMER software developments.","funder_award_id":"087656","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116423958.pdf","grobid_xml":"https://content.openalex.org/works/W2116423958.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1527927437","https://openalex.org/W1982481323","https://openalex.org/W2014719716","https://openalex.org/W2060000061","https://openalex.org/W2086130370","https://openalex.org/W2091448229","https://openalex.org/W2097698606","https://openalex.org/W2097817417","https://openalex.org/W2100990314","https://openalex.org/W2105644689","https://openalex.org/W2109872885","https://openalex.org/W2111373249","https://openalex.org/W2124195867","https://openalex.org/W2124285343","https://openalex.org/W2131736388","https://openalex.org/W2135252110","https://openalex.org/W2139430573","https://openalex.org/W2141885858","https://openalex.org/W2144363281","https://openalex.org/W2147231162","https://openalex.org/W2161062388","https://openalex.org/W2163105490","https://openalex.org/W2164940334","https://openalex.org/W2171097261","https://openalex.org/W2171419407","https://openalex.org/W2914405292","https://openalex.org/W4210323379","https://openalex.org/W4211054902","https://openalex.org/W4238052567","https://openalex.org/W4240921265","https://openalex.org/W4246995357"],"related_works":["https://openalex.org/W24553703","https://openalex.org/W4211000692","https://openalex.org/W4212920271","https://openalex.org/W2612240612","https://openalex.org/W4324018414","https://openalex.org/W4211208250","https://openalex.org/W4211054902","https://openalex.org/W1649706580","https://openalex.org/W3195608031","https://openalex.org/W2026467841"],"abstract_inverted_index":{"The":[0,106,129],"InterPro":[1,54,145],"database":[2,122],"(http://www.ebi.ac.uk/interpro/)":[3],"integrates":[4],"together":[5],"predictive":[6],"models":[7],"or":[8,165],"'signatures'":[9],"representing":[10],"protein":[11],"domains,":[12],"families":[13],"and":[14,31,37,112,123,126,139],"functional":[15],"sites":[16],"from":[17],"multiple,":[18],"diverse":[19],"source":[20,49],"databases:":[21],"Gene3D,":[22],"PANTHER,":[23],"Pfam,":[24],"PIRSF,":[25],"PRINTS,":[26],"ProDom,":[27],"PROSITE,":[28],"SMART,":[29],"SUPERFAMILY":[30],"TIGRFAMs.":[32],"Integration":[33],"is":[34],"performed":[35],"manually":[36],"approximately":[38,43],"half":[39],"of":[40,76,96,136,141],"the":[41,48,63,74,94,101,117,124,152,168],"total":[42],"58,000":[44],"signatures":[45,66],"available":[46],"in":[47,83,100],"databases":[50],"belong":[51],"to":[52,60,116],"an":[53],"entry.":[55],"Recently,":[56],"we":[57],"have":[58],"started":[59],"also":[61],"display":[62],"remaining":[64],"un-integrated":[65],"via":[67,151,156],"our":[68,88],"web":[69,107,153,157],"interface.":[70],"Other":[71],"developments":[72],"include":[73],"provision":[75],"non-signature":[77],"data,":[78,82],"such":[79],"as":[80,91,93],"structural":[81],"new":[84],"XML":[85,104],"files":[86,161],"on":[87],"FTP":[89,164],"site,":[90],"well":[92],"inclusion":[95],"matchless":[97],"UniProtKB":[98,137],"proteins":[99],"existing":[102],"match":[103],"files.":[105],"interface":[108],"has":[109],"been":[110],"extended":[111],"now":[113],"links":[114],"out":[115],"ADAN":[118],"predicted":[119],"protein-protein":[120],"interaction":[121],"SPICE":[125],"Dasty":[127],"viewers.":[128],"latest":[130],"public":[131],"release":[132],"(v18.0)":[133],"covers":[134],"79.8%":[135],"(v14.1)":[138],"consists":[140],"16":[142],"549":[143],"entries.":[144],"data":[146],"may":[147],"be":[148],"accessed":[149],"either":[150],"address":[154],"above,":[155],"services,":[158],"by":[159,162,166],"downloading":[160],"anonymous":[163],"using":[167],"InterProScan":[169],"search":[170],"software":[171],"(http://www.ebi.ac.uk/Tools/InterProScan/).":[172]},"counts_by_year":[{"year":2026,"cited_by_count":46},{"year":2025,"cited_by_count":118},{"year":2024,"cited_by_count":112},{"year":2023,"cited_by_count":111},{"year":2022,"cited_by_count":128},{"year":2021,"cited_by_count":192},{"year":2020,"cited_by_count":121},{"year":2019,"cited_by_count":85},{"year":2018,"cited_by_count":72},{"year":2017,"cited_by_count":80},{"year":2016,"cited_by_count":54},{"year":2015,"cited_by_count":92},{"year":2014,"cited_by_count":80},{"year":2013,"cited_by_count":132},{"year":2012,"cited_by_count":203}],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}
