{"id":"https://openalex.org/W2120261805","doi":"https://doi.org/10.1093/nar/gkn280","title":"AsiDesigner: exon-based siRNA design server considering alternative splicing","display_name":"AsiDesigner: exon-based siRNA design server considering alternative splicing","publication_year":2008,"publication_date":"2008-05-14","ids":{"openalex":"https://openalex.org/W2120261805","doi":"https://doi.org/10.1093/nar/gkn280","mag":"2120261805","pmid":"https://pubmed.ncbi.nlm.nih.gov/18480122"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkn280","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn280","pdf_url":"https://academic.oup.com/nar/article-pdf/36/suppl_2/W97/18781418/gkn280.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/36/suppl_2/W97/18781418/gkn280.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100724130","display_name":"Young-Kyu Park","orcid":"https://orcid.org/0000-0001-8283-7813"},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I171717699","display_name":"Genome Research Foundation","ror":"https://ror.org/03khjyh83","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I171717699"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young-Kyu Park","raw_affiliation_strings":["Medical Genomics Research Center, KRIBB, Daejeon 305-806, Korea"],"affiliations":[{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806, Korea","institution_ids":["https://openalex.org/I171717699","https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762907","display_name":"Seongmin Park","orcid":"https://orcid.org/0000-0002-1030-4935"},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong-Min Park","raw_affiliation_strings":["Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea"],"affiliations":[{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea","institution_ids":["https://openalex.org/I73616290","https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033550557","display_name":"Young\u2010Chul Choi","orcid":"https://orcid.org/0000-0001-5525-6861"},"institutions":[{"id":"https://openalex.org/I4210131847","display_name":"Genomics Medicine (Ireland)","ror":"https://ror.org/03c5c0a39","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210131847"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["IE","KR"],"is_corresponding":false,"raw_author_name":"Young-Chul Choi","raw_affiliation_strings":["Medical Genomics Research Center, KRIBB, Daejeon 305-806,","Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea"],"affiliations":[{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806,","institution_ids":["https://openalex.org/I4210131847","https://openalex.org/I73616290"]},{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea","institution_ids":["https://openalex.org/I73616290","https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037879375","display_name":"Doheon Lee","orcid":"https://orcid.org/0000-0001-9070-4316"},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Doheon Lee","raw_affiliation_strings":["Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea","Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea","institution_ids":["https://openalex.org/I73616290","https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026175736","display_name":"Misun Won","orcid":"https://orcid.org/0000-0001-6626-0647"},"institutions":[{"id":"https://openalex.org/I4210131847","display_name":"Genomics Medicine (Ireland)","ror":"https://ror.org/03c5c0a39","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210131847"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["IE","KR"],"is_corresponding":false,"raw_author_name":"Misun Won","raw_affiliation_strings":["Medical Genomics Research Center, KRIBB, Daejeon 305-806,","Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea"],"affiliations":[{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806,","institution_ids":["https://openalex.org/I4210131847","https://openalex.org/I73616290"]},{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea","institution_ids":["https://openalex.org/I73616290","https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100653720","display_name":"Young Joo Kim","orcid":"https://orcid.org/0000-0001-9379-656X"},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I4210131847","display_name":"Genomics Medicine (Ireland)","ror":"https://ror.org/03c5c0a39","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210131847"]}],"countries":["IE","KR"],"is_corresponding":false,"raw_author_name":"Young Joo Kim","raw_affiliation_strings":["Medical Genomics Research Center, KRIBB, Daejeon 305-806,","Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea"],"affiliations":[{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806,","institution_ids":["https://openalex.org/I4210131847","https://openalex.org/I73616290"]},{"raw_affiliation_string":"Medical Genomics Research Center, KRIBB, Daejeon 305-806, 2 Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 and 3 Bioneer, 49-3 Moonpyung-dong, Daedok, Daejeon 306-220, Korea","institution_ids":["https://openalex.org/I73616290","https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100724130"],"corresponding_institution_ids":["https://openalex.org/I171717699","https://openalex.org/I73616290"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.6543,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.8332773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"36","issue":"suppl_2","first_page":"W97","last_page":"W103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.8069905042648315},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7934085726737976},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"Gene silencing","score":0.7231467962265015},{"id":"https://openalex.org/keywords/small-interfering-rna","display_name":"Small interfering RNA","score":0.6739360690116882},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"Gene knockdown","score":0.6342092752456665},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.630790650844574},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.6181125044822693},{"id":"https://openalex.org/keywords/trans-acting-sirna","display_name":"Trans-acting siRNA","score":0.569119393825531},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.5430928468704224},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.47146397829055786},{"id":"https://openalex.org/keywords/rna-silencing","display_name":"RNA silencing","score":0.45406290888786316},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.45157426595687866},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.3958505690097809},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.35775965452194214},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.3164792060852051},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.28460127115249634},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.09883618354797363}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.8069905042648315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7934085726737976},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7231467962265015},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.6739360690116882},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6342092752456665},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.630790650844574},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.6181125044822693},{"id":"https://openalex.org/C60723119","wikidata":"https://www.wikidata.org/wiki/Q7833577","display_name":"Trans-acting siRNA","level":5,"score":0.569119393825531},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5430928468704224},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.47146397829055786},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.45406290888786316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45157426595687866},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.3958505690097809},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35775965452194214},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3164792060852051},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.28460127115249634},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.09883618354797363}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkn280","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn280","pdf_url":"https://academic.oup.com/nar/article-pdf/36/suppl_2/W97/18781418/gkn280.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:18480122","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18480122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:http://repository.kribb.re.kr:8080/:201005/8478","is_oa":false,"landing_page_url":"http://doi.org/10.1093/nar/gkn280","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/7647.pdf","raw_type":"Article"},{"id":"pmh:oai:koasas.kaist.ac.kr:10203/25078","is_oa":false,"landing_page_url":"http://hdl.handle.net/10203/25078","pdf_url":null,"source":{"id":"https://openalex.org/S4306402435","display_name":"KAIST Institutional Repository (KAIST)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157485424","host_organization_name":"Korea Advanced Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I157485424"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2447810","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2447810","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkn280","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn280","pdf_url":"https://academic.oup.com/nar/article-pdf/36/suppl_2/W97/18781418/gkn280.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321640","display_name":"Ministry of Knowledge Economy","ror":"https://ror.org/008nkqk13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120261805.pdf","grobid_xml":"https://content.openalex.org/works/W2120261805.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W97427672","https://openalex.org/W1509099686","https://openalex.org/W1520518044","https://openalex.org/W1605041274","https://openalex.org/W1611419331","https://openalex.org/W1982944995","https://openalex.org/W1986687961","https://openalex.org/W1992794281","https://openalex.org/W1996164865","https://openalex.org/W1996609303","https://openalex.org/W2006917788","https://openalex.org/W2009818318","https://openalex.org/W2015292449","https://openalex.org/W2043828851","https://openalex.org/W2047277267","https://openalex.org/W2049772182","https://openalex.org/W2055043387","https://openalex.org/W2071596792","https://openalex.org/W2075978325","https://openalex.org/W2078187809","https://openalex.org/W2078795489","https://openalex.org/W2082213106","https://openalex.org/W2087452137","https://openalex.org/W2089465951","https://openalex.org/W2095674416","https://openalex.org/W2097131232","https://openalex.org/W2100600738","https://openalex.org/W2102309391","https://openalex.org/W2106082032","https://openalex.org/W2109609799","https://openalex.org/W2110455072","https://openalex.org/W2119340328","https://openalex.org/W2127843746","https://openalex.org/W2128439914","https://openalex.org/W2128459533","https://openalex.org/W2129205448","https://openalex.org/W2129222324","https://openalex.org/W2137553623","https://openalex.org/W2146634740","https://openalex.org/W2149538815","https://openalex.org/W2152993806","https://openalex.org/W2154186552","https://openalex.org/W2156336405","https://openalex.org/W2160923685","https://openalex.org/W2164240862","https://openalex.org/W2165366948","https://openalex.org/W2166802510","https://openalex.org/W2169718128","https://openalex.org/W6603984413"],"related_works":["https://openalex.org/W2044279756","https://openalex.org/W2392176201","https://openalex.org/W1930224804","https://openalex.org/W2039740951","https://openalex.org/W1968291875","https://openalex.org/W2783595154","https://openalex.org/W2160381063","https://openalex.org/W2167018286","https://openalex.org/W2373307833","https://openalex.org/W2072680951"],"abstract_inverted_index":{"RNA":[0,6],"interference":[1],"(RNAi)":[2],"with":[3,123],"small":[4],"interfering":[5],"(siRNA)":[7],"has":[8],"become":[9],"a":[10,61,102,119,142,158,169],"powerful":[11],"tool":[12],"in":[13,38,202],"functional":[14,203],"and":[15,42,125,128,176,181,207],"medical":[16],"genomic":[17],"research":[18],"through":[19],"directed":[20],"post-transcriptional":[21],"gene":[22,80,171,189],"silencing.":[23,81],"In":[24],"order":[25],"to":[26,52,72,105,145,156],"apply":[27],"RNAi":[28],"technique":[29],"for":[30,74,77,93],"eukaryotic":[31],"organisms,":[32],"where":[33,151],"frequent":[34],"alternative":[35,75],"splicing":[36,76],"results":[37],"diversification":[39],"of":[40,44,56,90,96,109,135],"mRNAs":[41,100],"finally":[43],"proteins,":[45],"we":[46,140],"need":[47],"spliced":[48],"mRNA":[49,78,160,166],"isoform":[50,161],"silencing":[51,95,190],"study":[53],"the":[54,88,94,107,130,147,177],"function":[55],"individual":[57],"proteins.":[58],"AsiDesigner":[59,178,196,212],"is":[60,193,213],"web-based":[62],"siRNA":[63,69],"design":[64,70,117],"software":[65],"system,":[66],"which":[67],"provides":[68,83],"capability":[71],"account":[73],"level":[79],"It":[82,192],"numerous":[84],"novel":[85,143],"functions":[86],"including":[87],"designing":[89],"common":[91,148],"siRNAs":[92,111,152],"more":[97,163],"than":[98,164],"two":[99,165],"simultaneously,":[101],"scoring":[103],"scheme":[104],"evaluate":[106,146],"performance":[108],"designed":[110,155],"by":[112],"adopting":[113],"currently":[114],"known":[115],"key":[116],"factors,":[118],"stepwise":[120],"off-target":[121],"searching":[122],"BLAST":[124],"FASTA":[126],"algorithms":[127],"checking":[129],"folding":[131],"secondary":[132],"structure":[133],"energy":[134],"siRNAs.":[136],"To":[137],"do":[138],"this,":[139],"developed":[141,174],"algorithm":[144,175],"target":[149,170],"region,":[150],"can":[153],"be":[154],"knockdown":[157],"specific":[159],"or":[162],"isoforms":[167],"from":[168],"simultaneously.":[172],"The":[173],"were":[179],"tested":[180],"validated":[182],"as":[183],"very":[184],"effective":[185],"throughout":[186],"widely":[187],"performed":[188],"experiments.":[191],"expected":[194],"that":[195],"will":[197],"play":[198],"an":[199],"important":[200],"role":[201],"genomics,":[204],"drug":[205],"discovery":[206],"other":[208],"molecular":[209],"biological":[210],"research.":[211],"freely":[214],"accessible":[215],"at":[216],"http://sysbio.kribb.re.kr/AsiDesigner/.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}