{"id":"https://openalex.org/W2125728871","doi":"https://doi.org/10.1093/nar/gkl746","title":"SISYPHUS\u2014structural alignments for proteins with non-trivial relationships","display_name":"SISYPHUS\u2014structural alignments for proteins with non-trivial relationships","publication_year":2006,"publication_date":"2006-10-26","ids":{"openalex":"https://openalex.org/W2125728871","doi":"https://doi.org/10.1093/nar/gkl746","mag":"2125728871","pmid":"https://pubmed.ncbi.nlm.nih.gov/17068077"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkl746","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl746","pdf_url":"https://academic.oup.com/nar/article-pdf/35/suppl_1/D253/17422400/gkl746.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/35/suppl_1/D253/17422400/gkl746.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003886572","display_name":"Antonina Andreeva","orcid":"https://orcid.org/0000-0002-0450-0091"},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Antonina Andreeva","raw_affiliation_strings":["MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK. tony@mrc-lmb.cam.ac.uk","MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK"],"affiliations":[{"raw_affiliation_string":"MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK. tony@mrc-lmb.cam.ac.uk","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077634829","display_name":"Andreas Prli\u0107","orcid":"https://orcid.org/0000-0001-6346-6391"},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andreas Prli\u0107","raw_affiliation_strings":["Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK","1Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK"],"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"1Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007549481","display_name":"Tim Hubbard","orcid":"https://orcid.org/0000-0002-1767-9318"},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tim J. P. Hubbard","raw_affiliation_strings":["Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK","1Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK"],"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"1Wellcome Trust Sanger InstituteHinxton, Cambridge CB10 1SA, UK","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025834882","display_name":"Alexey G. Murzin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexey G. Murzin","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003886572"],"corresponding_institution_ids":["https://openalex.org/I170203145"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":4.4979,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.95291788,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"35","issue":"suppl_1","first_page":"D253","last_page":"D259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7096178531646729},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6333586573600769},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.5981297492980957},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5638824701309204},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5230249762535095},{"id":"https://openalex.org/keywords/protein-structure-database","display_name":"Protein structure database","score":0.5099266767501831},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.47899410128593445},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.43617966771125793},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.42729100584983826},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.42381128668785095},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34847384691238403},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3279200494289398},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22253990173339844},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.2022632658481598},{"id":"https://openalex.org/keywords/sequence-database","display_name":"Sequence database","score":0.13398805260658264}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7096178531646729},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6333586573600769},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.5981297492980957},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5638824701309204},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5230249762535095},{"id":"https://openalex.org/C136475424","wikidata":"https://www.wikidata.org/wiki/Q7251500","display_name":"Protein structure database","level":4,"score":0.5099266767501831},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.47899410128593445},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.43617966771125793},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.42729100584983826},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42381128668785095},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34847384691238403},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3279200494289398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22253990173339844},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2022632658481598},{"id":"https://openalex.org/C41584329","wikidata":"https://www.wikidata.org/wiki/Q175902","display_name":"Sequence database","level":3,"score":0.13398805260658264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkl746","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl746","pdf_url":"https://academic.oup.com/nar/article-pdf/35/suppl_1/D253/17422400/gkl746.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:17068077","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17068077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/85a6e296-b37a-41b1-9efb-a5d590fa736e","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/85a6e296-b37a-41b1-9efb-a5d590fa736e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andreeva, A, Prli\u0107, A, Hubbard, T J P & Murzin, A G 2007, 'SISYPHUS--structural alignments for proteins with non-trivial relationships', Nucleic Acids Research, vol. 35, no. suppl 1 (Database issue), N/A, pp. D253-D259. https://doi.org/10.1093/nar/gkl746","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:2284699","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1635320","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1635320","is_oa":true,"landing_page_url":"http://doi.org/10.1093/nar/gkl746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkl746","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl746","pdf_url":"https://academic.oup.com/nar/article-pdf/35/suppl_1/D253/17422400/gkl746.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125728871.pdf","grobid_xml":"https://content.openalex.org/works/W2125728871.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1978012062","https://openalex.org/W1981575795","https://openalex.org/W1986969007","https://openalex.org/W1997199912","https://openalex.org/W2000377676","https://openalex.org/W2005795025","https://openalex.org/W2011469637","https://openalex.org/W2013404472","https://openalex.org/W2033111093","https://openalex.org/W2051895548","https://openalex.org/W2056807348","https://openalex.org/W2074069606","https://openalex.org/W2074388759","https://openalex.org/W2085277871","https://openalex.org/W2105644689","https://openalex.org/W2106531843","https://openalex.org/W2130479394","https://openalex.org/W2148047088","https://openalex.org/W2158304452","https://openalex.org/W2158714788","https://openalex.org/W2161062388","https://openalex.org/W2164789204","https://openalex.org/W2414307244"],"related_works":["https://openalex.org/W646353556","https://openalex.org/W1989756167","https://openalex.org/W2121688928","https://openalex.org/W2607853144","https://openalex.org/W1535721329","https://openalex.org/W2059672303","https://openalex.org/W2013950502","https://openalex.org/W2015399150","https://openalex.org/W2117699649","https://openalex.org/W2181530468"],"abstract_inverted_index":{"With":[0],"the":[1,7,52,99,106,132],"increasing":[2],"amount":[3],"of":[4,9,64,89,102,115,141,169,187],"structural":[5,39,120,144,156],"data,":[6],"number":[8],"homologous":[10],"protein":[11,65,92,103,155,188],"structures":[12,190],"bearing":[13],"topological":[14],"irregularities":[15],"is":[16,196],"steadily":[17],"growing.":[18],"These":[19],"include":[20],"proteins":[21,116],"with":[22,117,178],"circular":[23],"permutations,":[24],"segment-swapping,":[25],"context-dependent":[26],"folding":[27],"or":[28,59,164],"chameleon":[29],"sequences":[30],"that":[31,158,182],"can":[32],"adopt":[33],"alternative":[34],"secondary":[35],"structures.":[36],"Their":[37],"non-trivial":[38,62,119],"relationships":[40,66,121],"are":[41,67,152,176],"readily":[42],"identified":[43],"during":[44],"expert":[45],"analysis":[46],"but":[47],"their":[48,147,192],"automatic":[49],"identification":[50],"using":[51],"existing":[53],"computational":[54],"tools":[55],"still":[56],"remains":[57],"difficult":[58],"impossible.":[60],"Such":[61],"cases":[63],"known":[68],"to":[69,73,78,110,131,167],"pose":[70],"a":[71,85,112,129,139,180],"problem":[72],"multiple":[74,150,174],"alignment":[75],"algorithms":[76],"and":[77,109,146,191],"impede":[79],"comparative":[80],"modeling":[81],"studies.":[82],"They":[83],"support":[84],"new":[86],"emerging":[87],"concept":[88],"evolutionary":[90],"changeable":[91],"fold,":[93],"which":[94],"creates":[95],"practical":[96],"difficulties":[97],"for":[98,154],"hierarchical":[100],"classifications":[101],"structures.To":[104],"facilitate":[105],"understanding":[107],"of,":[108],"provide":[111],"comprehensive":[113],"annotation":[114],"such":[118],"we":[122],"have":[123],"created":[124],"SISYPHUS":[125,136,173],"([Sigmaomeganuphiomicronzeta]--in":[126],"Greek":[127],"crafty),":[128],"compendium":[130],"SCOP":[133],"database.":[134],"The":[135,149,172,194],"database":[137,195],"contains":[138],"collection":[140],"manually":[142],"curated":[143],"alignments":[145,151,175],"inter-relationships.":[148],"constructed":[153],"regions":[157],"range":[159],"from":[160,198],"oligomeric":[161],"biological":[162],"units,":[163],"individual":[165],"domains":[166],"fragments":[168],"different":[170],"size.":[171],"displayed":[177],"SPICE,":[179],"browser":[181],"provides":[183],"an":[184],"integrated":[185],"view":[186],"sequences,":[189],"annotations.":[193],"available":[197],"http://sisyphus.mrc-cpe.cam.ac.uk.":[199]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-04T08:04:53.788161","created_date":"2025-10-10T00:00:00"}
