{"id":"https://openalex.org/W2135859936","doi":"https://doi.org/10.1093/nar/gkl340","title":"TOM: a web-based integrated approach for identification of candidate disease genes","display_name":"TOM: a web-based integrated approach for identification of candidate disease genes","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W2135859936","doi":"https://doi.org/10.1093/nar/gkl340","mag":"2135859936","pmid":"https://pubmed.ncbi.nlm.nih.gov/16845011"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkl340","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl340","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkl340","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044102832","display_name":"Sabrina Rossi","orcid":"https://orcid.org/0000-0001-8853-0775"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Rossi","raw_affiliation_strings":["Functional Genomics Laboratory and Telethon Facility, DAMA Data Mining for Analysis of DNA Microarrays, Dipartimento di Morfologia ed Embriologia, Via Fossato di Mortara 64b, 44100 Ferrara, Italy. simona.rossi@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics Laboratory and Telethon Facility, DAMA Data Mining for Analysis of DNA Microarrays, Dipartimento di Morfologia ed Embriologia, Via Fossato di Mortara 64b, 44100 Ferrara, Italy. simona.rossi@gmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017574404","display_name":"D. Masotti","orcid":null},"institutions":[{"id":"https://openalex.org/I177477856","display_name":"Politecnico di Torino","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Masotti","raw_affiliation_strings":["Dipartimento di Automatica e Informatica (DAUIN), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Automatica e Informatica (DAUIN), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy,","institution_ids":["https://openalex.org/I177477856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081542076","display_name":"Christine Nardini","orcid":"https://orcid.org/0000-0001-7601-321X"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Nardini","raw_affiliation_strings":["Dipartimento di Elettronica, Informatica e Sistemistica (DEIS),University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informatica e Sistemistica (DEIS),University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy and","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067024369","display_name":"Elena Bonora","orcid":"https://orcid.org/0000-0001-6132-7734"},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I4210118694","display_name":"Medica (Italy)","ror":"https://ror.org/02qtpb069","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210118694"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Bonora","raw_affiliation_strings":["Unita `di Genetica Medica, Policlinico S. Orsola, via Massarenti 9, 40138 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unita `di Genetica Medica, Policlinico S. Orsola, via Massarenti 9, 40138 Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I4210118694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011953010","display_name":"Giovanni Romeo","orcid":"https://orcid.org/0000-0002-3444-5142"},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I4210118694","display_name":"Medica (Italy)","ror":"https://ror.org/02qtpb069","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210118694"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Romeo","raw_affiliation_strings":["Unita `di Genetica Medica, Policlinico S. Orsola, via Massarenti 9, 40138 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unita `di Genetica Medica, Policlinico S. Orsola, via Massarenti 9, 40138 Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I4210118694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005432629","display_name":"Enrico Macii","orcid":"https://orcid.org/0000-0001-9046-5618"},"institutions":[{"id":"https://openalex.org/I177477856","display_name":"Politecnico di Torino","ror":"https://ror.org/00bgk9508","country_code":"IT","type":"education","lineage":["https://openalex.org/I177477856"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Macii","raw_affiliation_strings":["Dipartimento di Automatica e Informatica (DAUIN), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Automatica e Informatica (DAUIN), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy,","institution_ids":["https://openalex.org/I177477856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043408422","display_name":"Luca Benini","orcid":"https://orcid.org/0000-0001-8068-3806"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Benini","raw_affiliation_strings":["Dipartimento di Elettronica, Informatica e Sistemistica (DEIS),University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informatica e Sistemistica (DEIS),University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy and","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036085776","display_name":"Stefano Volinia","orcid":"https://orcid.org/0000-0003-0910-3893"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Volinia","raw_affiliation_strings":["Functional Genomics Laboratory and Telethon Facility, DAMA Data Mining for Analysis of DNA Microarrays, Dipartimento di Morfologia ed Embriologia, Via Fossato di Mortara 64b, 44100 Ferrara, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics Laboratory and Telethon Facility, DAMA Data Mining for Analysis of DNA Microarrays, Dipartimento di Morfologia ed Embriologia, Via Fossato di Mortara 64b, 44100 Ferrara, Italy,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.8184,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93843862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"Web Server","first_page":"W285","last_page":"W292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7461299300193787},{"id":"https://openalex.org/keywords/geneticist","display_name":"Geneticist","score":0.7352861166000366},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.6491508483886719},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6065833568572998},{"id":"https://openalex.org/keywords/refseq","display_name":"RefSeq","score":0.5513786673545837},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5326307415962219},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5230646729469299},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5170027017593384},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.5139188766479492},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4507949650287628},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.4232904016971588},{"id":"https://openalex.org/keywords/web-resource","display_name":"Web resource","score":0.41042694449424744},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3400580883026123},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2581188678741455},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2559349238872528},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20493391156196594},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.15945667028427124}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7461299300193787},{"id":"https://openalex.org/C2776738285","wikidata":"https://www.wikidata.org/wiki/Q3126128","display_name":"Geneticist","level":2,"score":0.7352861166000366},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.6491508483886719},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6065833568572998},{"id":"https://openalex.org/C151810110","wikidata":"https://www.wikidata.org/wiki/Q7307074","display_name":"RefSeq","level":4,"score":0.5513786673545837},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5326307415962219},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5230646729469299},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5170027017593384},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.5139188766479492},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4507949650287628},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.4232904016971588},{"id":"https://openalex.org/C65603577","wikidata":"https://www.wikidata.org/wiki/Q3427877","display_name":"Web resource","level":2,"score":0.41042694449424744},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3400580883026123},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2581188678741455},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2559349238872528},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20493391156196594},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15945667028427124},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018511","descriptor_name":"Systems Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gkl340","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl340","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:16845011","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16845011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:cris.unibo.it:11585/35078","is_oa":true,"landing_page_url":"http://hdl.handle.net/11585/35078","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:338399","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1538851","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:iris.unife.it:11392/499107","is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/499107","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1538851","is_oa":true,"landing_page_url":"http://doi.org/10.1093/nar/gkl340","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkl340","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkl340","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4300000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1521652389","https://openalex.org/W1597538863","https://openalex.org/W1605637875","https://openalex.org/W1977002958","https://openalex.org/W2010975892","https://openalex.org/W2011365672","https://openalex.org/W2012698246","https://openalex.org/W2039872271","https://openalex.org/W2052244380","https://openalex.org/W2070412833","https://openalex.org/W2074950688","https://openalex.org/W2092868756","https://openalex.org/W2101181377","https://openalex.org/W2105813018","https://openalex.org/W2108181223","https://openalex.org/W2110065044","https://openalex.org/W2113962581","https://openalex.org/W2119412782","https://openalex.org/W2123352073","https://openalex.org/W2128985829","https://openalex.org/W2131994307","https://openalex.org/W2133219389","https://openalex.org/W2153294290","https://openalex.org/W2156750171","https://openalex.org/W2160697532","https://openalex.org/W2163424852","https://openalex.org/W2170076251","https://openalex.org/W2172159256","https://openalex.org/W2217809488","https://openalex.org/W2247766769","https://openalex.org/W2325949502","https://openalex.org/W3122709706","https://openalex.org/W4240802092","https://openalex.org/W4246066782","https://openalex.org/W4248234957","https://openalex.org/W4250808989"],"related_works":["https://openalex.org/W2173732482","https://openalex.org/W2611876325","https://openalex.org/W2167922509","https://openalex.org/W2107903949","https://openalex.org/W12006945","https://openalex.org/W2113949780","https://openalex.org/W1968956193","https://openalex.org/W4386739095","https://openalex.org/W1981194976","https://openalex.org/W2043801429"],"abstract_inverted_index":{"The":[0,64,91],"massive":[1],"production":[2],"of":[3,8,32,40,58,70,85,132,143],"biological":[4,34],"data":[5],"by":[6,36],"means":[7],"highly":[9],"parallel":[10],"devices":[11],"like":[12],"microarrays":[13],"for":[14,54,61,76,148],"gene":[15,74],"expression":[16,41,102],"has":[17],"paved":[18],"the":[19,30,55,67,77,80,94,107,122,126,141,154,157],"way":[20],"to":[21,124,167],"new":[22],"possible":[23],"approaches":[24],"in":[25,97],"molecular":[26],"genetics.":[27],"Among":[28],"them":[29],"possibility":[31],"inferring":[33],"answers":[35],"querying":[37],"large":[38],"amounts":[39],"data.":[42],"Based":[43],"on":[44,160,164],"this":[45],"principle,":[46],"we":[47],"present":[48,152],"here":[49,153],"TOM,":[50],"a":[51],"web-based":[52],"resource":[53],"efficient":[56],"extraction":[57],"candidate":[59,117],"genes":[60],"hereditary":[62,165],"diseases.":[63,150],"service":[65],"requires":[66],"previous":[68],"knowledge":[69],"at":[71,175],"least":[72],"another":[73],"responsible":[75],"disease":[78,87,145],"and":[79,103,112,128,138,156,163],"linkage":[81],"area,":[82],"or":[83,115],"else":[84],"two":[86],"associated":[88],"genetic":[89,133],"intervals.":[90],"algorithm":[92,172],"uses":[93],"information":[95],"stored":[96],"public":[98],"resources,":[99],"including":[100],"mapping,":[101],"functional":[104],"databases.":[105],"Given":[106],"queries,":[108],"TOM":[109],"will":[110],"select":[111],"list":[113],"one":[114],"more":[116],"genes.":[118],"This":[119],"approach":[120],"allows":[121],"geneticist":[123],"bypass":[125],"costly":[127],"time":[129],"consuming":[130],"tracing":[131],"markers":[134],"through":[135],"entire":[136],"families":[137],"might":[139],"improve":[140],"chance":[142],"identifying":[144],"genes,":[146],"particularly":[147],"rare":[149],"We":[151],"tool":[155],"results":[158],"obtained":[159],"known":[161],"benchmark":[162],"predisposition":[166],"familial":[168],"thyroid":[169],"cancer.":[170],"Our":[171],"is":[173],"available":[174],"http://www-micrel.deis.unibo.it/~tom/.":[176]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}